Hepatocyte Growth Factor may Act as an Early Therapeutic Predictor in Pneumonia

Nayeri, Fariba; Brudin, Lars; Darelid, Johan; Nilsson, Ingela; Frydén, Aril; Söderström, Claes; Forsberg, Pia

doi:10.1080/00365540110080890

Cited by 10 publications

(14 citation statements)

References 20 publications

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“…Our results from the present study show that monitoring of HGF concentrations predicted the effect of anti-biotic treatment in lung infections with high sensitivity. These results are in agreement with our previous observations [14] [15] and show that monitoring HGF during pneumonia might be a reasonable approach to evaluate therapy. Further studies are needed to determine if HGF has a role in the evaluation of empiric antibiotic treatment in infections caused by multiple resistant microorganisms.…”

Section: Parametersupporting

confidence: 83%

“…We previously examined HGF levels in pneumonia and showed that the presence of HGF correlated significantly with survival in this patient group [12]. We also showed that HGF concentration increased in serum and exhaled-breath condensate in patients with pneumonia [13] and that the amount of HGF decreased markedly within 48 hours of initiation of the appropriate antibiotic therapy [14]. In another study, we showed that HGF predicted the results of antibiotic therapy better than CRP did within 24 hours of initiation of pneumonia treatment [15].…”

Section: Introductionmentioning

confidence: 99%

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Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Abednazari¹,

Brudin²,

Almroth³

et al. 2014

ABB

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Rapid diagnosis and choice of appropriate antibiotic treatment might be life-saving in serious infectious diseases. Still the available markers that can evaluate and monitor the diagnosis and treatment are few. Hepatocyte growth factor (HGF) has been studied as a potent regenerative factor produced and released during injuries such as infectious diseases. Monitoring of HGF levels might predict therapy results better than C-reactive protein (CRP) within the first day of treatment in pneumonia. For further investigation of previous observations we aimed to study HGF as a first-day marker in over-representing infectious diseases in comparison to procalcitonin (PCT), CRP and body temperature. Fifty-one patients with community acquired infectious diseases were included consequently at admittance and the serum samples were collected before and within 18 -24 hours of treatment. HGF levels decreased significantly in case of efficient antibiotic therapy and HGF was shown to be better than PCT, CRP and body temperature to evaluate treatment. In patients with pneumonia, monitoring of HGF was most reasonable. HGF might be used as a therapeutic marker within the first day of empiric antibiotic treatment during infection.

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Section: Parametersupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Abednazari¹,

Brudin²,

Almroth³

et al. 2014

ABB

Self Cite

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“…In humans, serum levels of HGF in pneumonia patients are significantly elevated before treatment, but decrease in those responding to the initial antibiotic therapy, whereas they remain unchanged or further increase in those not responding to the therapy, suggesting that HGF may act as an early therapeutic predictor in pneumonia (36,37). HGF is also elevated in the bronchoalveolar lavage (BAL) fluid from acute respiratory distress syndrome patients with a poor prognosis, but not with a good prognosis, suggesting that HGF concentration in the BAL fluid reflects the severity of lung damage (38).…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte Growth Factor Protects Small Airway Epithelial Cells from Apoptosis Induced by Tumor Necrosis Factor-α or Oxidative Stress

et al. 2004

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Involvement of hepatocyte growth factor (HGF) in lung morphogenesis and regeneration has been established by in vitro and in vivo experiments in animals. In the present study, the protective activity of HGF against tumor necrosis factor (TNF)-␣ or hydrogen peroxide (H 2 O 2 )-induced damage of pulmonary epithelial cells was examined using the human small airway epithelial cell line (SAEC). Western blot analysis revealed that the receptor for HGF (c-Met) was highly expressed on the surface of SAEC and its downstream signal transduction pathway was functional. The SAEC was induced into apoptosis by the treatment with TNF-␣ or H 2 O 2 in a dose-dependant manner, but was significantly rescued from apoptosis in the presence of HGF. The HGF effect was evident when added not only at the same time but also within several hours after treatment. This protective activity of HGF against the TNF-␣-or H 2 O 2 -induced apoptosis was mediated, at least in part, by up-regulating the nuclear factor B activity and an increase in the ratio of apoptosis-suppressing to apoptosis-inducing proteins. These results suggest that administration of HGF might exhibit a potent function in vivo for protection and improvement of acute and chronic lung injuries induced by inflammation and/or oxidative stress. Lung development and morphogenesis begin in the fetal period of embryo and finally reach the formation of mature alveolar cells around 36 wk of gestation. The control of lung development is complicated and known to be influenced by the interaction between pulmonary epithelial and mesenchymal cells, which is mainly mediated by autocrine and paracrine mechanisms via a variety of polypeptides expressed on or secreted from mesenchymal cells (1).HGF, which was originally purified and cloned as a potent mitogen for mature hepatocytes in primary culture (2-4), is a cytokine mainly produced by cells of mesenchymal origin (5). Previous studies have demonstrated that HGF has multifunctional activities such as mitogenic, morphogenic, and motogenic on a variety of epithelial cells (5, 6), including pulmonary epithelial cells (7). Pulmonary mesenchymal cells synthesize and secrete HGF, which has been shown to be involved not only in the formation of bronchoalveolar structure during fetal development, but also in the repair process of injured distal organs such as liver and kidney (7-10). In the bleomycin-induced lung injury model in rats (11), HGF showed the proliferative effect on type II alveolar epithelial cells, but showed the antiproliferative effect on alveolar macrophages and fibroblasts mainly implicated in the occurrence of fibrotic changes of the lung. In addition, it has recently been shown that endogenous and exogenous HGF protects cardiac myocytes in a rat model of ischemia/reperfusion injury (12) and that the addition of HGF in the culture effectively protects adult rat cardiac myocytes from oxidative stress-induced apoptosis (13). Thus, it is speculated that HGF might play a role in the physiologic repair process of respiratory epithelium...

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“…However, the reliability of CRP as an indicator of a microbial infection is diminished due to its low specificity (4). It has been reported that levels of HGF, a multifunctional protein, are increased in several infection diseases such as sepsis, brucellosis, pneumonia, and urinary infections as well as cancers (14,15).…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that HGF is accounted for by malign cell transformation, proliferation, invasion, and metastasis of cancer cells (12,13). It has been reported that HGF levels are increased in sepsis, inflammatory pulmonary diseases, and pneumonia (14,15). Although HGF levels in serum and local fluids have been particularly investigated in acute and chronic inflammatory diseases, there are a limited number of studies on HGF levels and its prognostic value in infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia

Özden

Gödekmerdan²,

Ilhan³

et al. 2013

Turk J Med Sci

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Three acylhydrazone-based compounds were designed as novel neutral sensors for anions, and synthesized by simple steps in good yields. Their anion recognition properties were studied by UV-vis and 1 H-NMR spectroscopy. The results showed that the receptors 1, 2, and 3 all had a better selectivity for F − and CH 3 COO − , but no evident binding with Cl − , Br − , I − , NO − 3 , H2 PO − 4 , or HSO − 4 . The results indicated that anion recognition was achieved via convergent hydrogen bond interactions from acylhydrazone functionality on the side arms. The UV-vis data indicated that a 1:1 stoichiometry complex was formed between compounds 1, 2, or 3 and anions. The binding and selectivity were also tuned by the change of the place of the nitro group attached to the phenyl. Moreover, receptor 3 can act as the colorimetric sensor for such anions as F − and CH 3 COO − , and the recognition mechanism and binding mode were discussed.

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Hepatocyte Growth Factor may Act as an Early Therapeutic Predictor in Pneumonia

Cited by 10 publications

References 20 publications

Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Hepatocyte Growth Factor Is a Reliable Marker for Efficient Anti-Bacterial Therapy within the First Day of Treatment

Hepatocyte Growth Factor Protects Small Airway Epithelial Cells from Apoptosis Induced by Tumor Necrosis Factor-α or Oxidative Stress

Investigation of hepatocyte growth factor and proinflammatory cytokine levels in patients with febrile neutropenia

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