Abstract:Bone marrow mesenchymal stem cells(BMSCs) have great potential ability of multi-directional differentiation and reproductive activity. Recent studys have demonstrated that BMSCs can be induced into hepatocyte-like cells. However, the molecular mechanism of hepatocellular differentiation remains unknown. In this study, we investigated the nexus between p38 MAPK and NF-κB signaling pathway in the process of the hepatocellular differentiation. We isolated BMSCs from femurs and tibias of rats. The third generation… Show more
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