Hepatocyte Growth Factor and Digital Clubbing.

Hojo, Satoko; Fujita, Jiro; Yamadori, Ichiro; Ezaki, Toru; Watanabe, Seishiro; Yamanouchi, Hideo; Mikami, Hiroshi; Yamaji, Yutaka; Nishioka, Mikio; Takahara, Jiro

doi:10.2169/internalmedicine.36.44

Cited by 26 publications

(12 citation statements)

References 11 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These clinical features usually resolve within 2-5 months or sometimes longer after removal of the tumour, but they may reappear with recurrence of it [4,10,58]. The causes of digital clubbing and hypertrophic pulmonary osteoarthropathy could be an abnormal production of hepatocyte growth factor or an excessive release of hyaluronic acid by the tumour, respectively [54,59]. Those patients with hypertrophic pulmonary osteoarthropathy commonly report bilateral arthritic-like symptoms [3].…”

Section: Clinical Featuresmentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

SummarySolitary fibrous tumours of the pleura are rare. They are mesenchymal in origin. Initially, they were described in the pleura, but lately they have been reported in many other sites. Although the majority of these tumours are benign, some of them are malignant. Their unpredictable clinical course is probably related to their histological and morphological characteristics. The benign tumours may remain unproblematic for several years before changing into a malignant form. In order to define more accurately the clinical behaviour, diagnosis, management and outcome of these rare tumours, we reviewed the literature with particular attention to clinical presentation, methods of diagnosis, treatment and outcome. Furthermore, a modified algorithm was proposed for the management of these tumours.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

“…Hepatocyte growth factor is another potential stimulator of clubbing. [15] Sridhar et al [16] found higher levels of HGF in lung cancer patients with clubbing than in those without clubbing, suggesting that HGF may play a role in the formation of digital clubbing. Atkinson and Fox [17] suggested that vascular endothelial growth factor (VEGF) and PDGF expression is hypoxically enhanced after capillary occlusion and that VEGF may synergize with PDGF in inducing stromal and vascular changes present in digital clubbing.…”

Section: Discussionmentioning

confidence: 99%

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

et al. 2011

View full text Add to dashboard Cite

Takayasu arteriti genellikle yaşamın ikinci ve üçüncü on yılında genç kadınları etkileyen bir büyük damar vaskülitidir. Daha az sıklıkta çocukluk çağında da görülebilir. Bu yazıda tek taraflı çomak parmağı olan Takayasu arteritli 17 yaşındaki bir erkek olgu sunuldu. Hastanın sol üst ve alt ekstremitelerinde bir aydan beri devam eden kas zayıflığı ve miyaljisi vardı. Hipertansiyon ve abdominal üfürüm yoktu. Dijital subtraksiyon anjiyografide sol subklaviyan arterde total tıkanma ve sağ renal arterde ciddi daralma olduğu görüldü. Çomak parmak ve Takayasu arteriti birlikteliği yaygın değildir. Bilgilerimize göre bugüne kadar yalnız iki olgunun sunumu yapılmıştır.Anahtar sözcükler: Çomak parmak; dijital subtraksiyon anjiyografi; hipertansiyon; Takayasu arteriti.Takayasu arteritis is a large vessel vasculitis that usually affects young female patients during the second and third decades of life. Less commonly, it can also be seen childhood. In this article, we describe a case of Takayasu arteritis in a 17 year-old-boy who presented with unilateral digital clubbing. The patient had also a one-month history of muscle weakness and myalgia in the left upper and lower extremity. There was no hypertension or abdominal bruit. Digital subtraction angiography revealed a total occlusion of the left subclavian artery and a severe narrowing of the right renal artery. The association of digital clubbing and Takayasuʼs arteritis is not common. To our knowledge, only two cases have been reported to date.

show abstract

“…9,10 O diagnóstico tem sofrido modificações durante os últimos anos, com base nas tentativas de uma classificação clínica que o defina. Frente à suspeita clínica de baqueteamento, pode-se utilizar a avaliação da relação da profundidade das falanges distais e das articulações interfalangeanas e a relação dessas duas profundidades com relação normal menor do que um.…”

Section: By the Dorsal (E) And Medial (A) Aspects Of The Distal Phalaunclassified

“…1,16,17,18 A apresentação de baqueteamento digital como manifestação inicial de neoplasia broncogênica é rara, pois normalmente sua formação parece depender da produção hepatic cirrhosis, hepatocarcinoma and pulmonary adenocarcinoma. 9,10 The diagnosis has undergone modifications during recent years following attempts of creating a clinical classification that would define it. When suspected clinical suspicion, one may choose to proceed to an assessment of the ratio of depth between the distal phalanges and interdigital joints, and the ratio of these two depths to a normal lessthan-one ratio.…”

Section: By the Dorsal (E) And Medial (A) Aspects Of The Distal Phalamentioning

confidence: 99%

Baqueteamento digital como manifestação inicial de neoplasia pulmonar

Macedo

Fusari

Almeida

et al. 2004

An. Bras. Dermatol.

View full text Add to dashboard Cite

Resumo: Os autores descrevem caso de baqueteamento digital, o qual possibilitou diagnós-tico de carcinoma broncogênico em paciente assintomático. Baseados em levantamento bibliográfico, discutem sua fisiopatologia, associações com alterações sistêmicas e métodos para diagnóstico precoce, enfatizando sua importância, vista a associação do mesmo com várias doenças, incluindo neoplasias pulmonares. Palavras-chave: carcinoma broncogênico; osteoartropatia hipertrófica secundária. Summary: The authors describe a case of digital clubbing, which led to a diagnosis of bronchogenic cancer in an asymptomatic patient. Based on a review of the literature, we discuss its physiopathological aspects, associations with systemic conditions and recent methods for early diagnosis of digital clubbing. We emphasize the disease's importance in light of its association with several other diseases, including bronchogenic cancer.

show abstract

Hepatocyte Growth Factor and Digital Clubbing.

Cited by 26 publications

References 11 publications

Solitary fibrous tumours of the pleura

Solitary fibrous tumours of the pleura

A Takayasu's Arteritis Case with Unilateral Digital Clubbing

Baqueteamento digital como manifestação inicial de neoplasia pulmonar

Contact Info

Product

Resources

About