Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high‐fat diet‐fed mice

Jing, Yali; Sun, Qingmin; Xiong, Xiaolu; Wang, Mengqi; Tang, Sunyinyan; Cao, Shu; Bi, Yan; Zhu, Dalong

doi:10.1111/jdi.12904

Cited by 22 publications

(21 citation statements)

References 29 publications

(33 reference statements)

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“…In 2008, the prevalence of diabetes mellitus in people living in Sandong Province who were aged ≥ 20 years was 9.9%, which was significantly higher than the average level in the whole country. For our study, we used a multi-stage stratified cluster sampling method to select participants, as described in detail in a previous study [ 27 ]. A total of 2481 diabetes patients registered in the NCDs management system in the sampling communities or villages were recruited to the survey, and 2183 diabetic patients for whom a complete dataset were available were included in the analysis, with a response rate of 87.99%.…”

Section: Methodsmentioning

confidence: 99%

Blood Glucose Monitoring and Its Determinants in Diabetic Patients: A Cross-Sectional Study in Shandong, China

et al. 2018

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IntroductionThe aim of this study was to explore the status of blood glucose monitoring and its determinants in diabetic patients in Shandong Province, China.MethodsThis was a cross-sectional survey conducted from 31 August to 12 October 12, in Shandong Province. A multi-stage stratified cluster sampling method was used to select participants. A total of 2183 diabetic patients were included in the analysis. Frequencies and proportions were used to describe the data, and multiple binary logistic regressions were performed to determine factors associated with blood glucose monitoring.ResultsOf the participants, 51.4% tested their blood glucose level more than once a month. The multivariate logistic regression model showed that seven variables were significantly associated with the frequency of blood glucose monitoring: education level, residence, household income, self-reported health, physical examination, anti-diabetic drug or insulin injection, and comorbidity.ConclusionsThe level of blood glucose monitoring among diabetic patients in Shandong Province is low. Based on these results we recommend that the cost of blood glucose monitoring by professionals in laboratories be reimbursed or at least reduced and that diabetic patients be encouraged to undergo regular physical examinations.Electronic supplementary materialThe online version of this article (10.1007/s13300-018-0499-9) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Blood Glucose Monitoring and Its Determinants in Diabetic Patients: A Cross-Sectional Study in Shandong, China

et al. 2018

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“…The adipokine visfatin that is released from the adipose tissue of obese individuals has also been shown to activate the pro-inflammatory STAT3 signaling pathway and NF-κB in the human liver cell line HepG2 and promote their insulin resistant state (108). Nevertheless, the hepatocyte growth factor (HGF) can alleviate the insulin resistance of hepatocytes and control their triglyceride and cholesterol contents (109).…”

Section: Livermentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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“…Insulin is one of the most important hormones in the body. Its secretion has been precisely regulated by various substances such as nutrients, neurotransmitters, and hormones [ 39 , 40 , 41 ]. Research has shown that a key role for the brain is to act, via the sympathetic nervous system, in the rapid, highly coordinated, and reciprocal changes of insulin secretion and insulin sensitivity that preserve glucose homeostasis in a setting of cold exposure [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice

Yao

Yang

Lian

et al. 2018

IJMS

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Protein O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) regulates many biological processes. Studies have shown that O-GlcNAc modification levels can increase during acute stress and suggested that this may contribute to the survival of the cell. This study investigated the possible effects of O-GlcNAcylation that regulate glucose metabolism, apoptosis, and autophagy in the liver after acute cold stress. Male C57BL/6 mice were exposed to cold conditions (4 °C) for 0, 2, 4, and 6 h, then their livers were extracted and the expression of proteins involved in glucose metabolism, apoptosis, and autophagy was determined. It was found that acute cold stress increased global O-GlcNAcylation and protein kinase B (AKT) phosphorylation levels. This was accompanied by significantly increased activation levels of the glucose metabolism regulators 160 kDa AKT substrate (AS160), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), and glycogen synthase kinase-3β (GSK3β). The levels of glycolytic intermediates, fructose-1,6-diphosphate (FDP) and pyruvic acid (PA), were found to show a brief increase followed by a sharp decrease. Additionally, adenosine triphosphate (ATP), as the main cellular energy source, had a sharp increase. Furthermore, the B-cell lymphoma 2(Bcl-2)/Bcl-2-associated X (Bax) ratio was found to increase, whereas cysteine-aspartic acid protease 3 (caspase-3) and light chain 3-II (LC3-II) levels were reduced after acute cold stress. Therefore, acute cold stress was found to increase O-GlcNAc modification levels, which may have resulted in the decrease of the essential processes of apoptosis and autophagy, promoting cell survival, while altering glycose transport, glycogen synthesis, and glycolysis in the liver.

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Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high‐fat diet‐fed mice

Abstract: HGF treatment can ameliorate hepatic insulin resistance and steatosis through regulation of lipid metabolism. These effects might occur through FXR-SHP axis dependent transcriptional activity. This article is protected by copyright. All rights reserved.

Cited by 22 publications

References 29 publications

Blood Glucose Monitoring and Its Determinants in Diabetic Patients: A Cross-Sectional Study in Shandong, China

Blood Glucose Monitoring and Its Determinants in Diabetic Patients: A Cross-Sectional Study in Shandong, China

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice

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