Abstract:Primary human hepatocytes are generally considered the “gold standard” for
in vitro
evaluation of human drug metabolism, drug‐drug interactions (DDIs), and hepatotoxicity. Successful cryopreservation to retain high viability and plateability (ability to be cultured) allows human hepatocytes to be used routinely for experimentation. Assays developed with human hepatocytes include metabolic stability, metabolite profiling, P450 inhibition, P450 induction, and
in vitro
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