Hepatocellular carcinoma with skeletal metastasis.

Golimbu, Cornelia; Firooznia, Hossein; Rafii, Mahvash

doi:10.1148/radiology.154.3.2982174

Cited by 31 publications

(17 citation statements)

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“…Bone metastases from HCC present as osteolytic, expansile, and hypervascular bone lesions [4,7,8]. Although bone metastasis from HCC is not very frequent, it can be the initial manifestation of HCC in some cases [2,4,9].…”

Section: Discussionmentioning

confidence: 99%

Transcatheter arterial embolization for bone metastases from hepatocellular carcinoma

et al. 2001

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The objective of this study was to determine which of the following three methods is the most effective for the treatment of bone metastases from hepatocellular carcinoma (HCC): transcatheter arterial embolization (TAE); combination of TAE and external radiotherapy; or external radiotherapy alone. Thirty-nine metastatic bone lesions from HCC in 33 patients were retrospectively reviewed. Each lesion underwent either TAE alone (group A, n = 11), TAE followed by radiotherapy (group B, n = 17), or radiotherapy alone (group C, n = 11). They were evaluated on the following subjects: pain relief; improvement of daily activities; and complications. Each treatment was effective for pain relief (89-94%) and improvement of daily activities (73-82%). The mean time interval from the beginning of each treatment to the onset of initial pain relief was 4.7 days in group A, 4.8 days in group B, and 15 days in group C. Recurrence of the pain after the initial pain relief was noted in 75% in group A, 20% in group B, and 88% in group C. Pyrexia and local pain commonly occurred after TAE. In conclusion, TAE is effective in relieving pain immediately and in improving the patients' daily activities. The combination of TAE and radiotherapy is recommended for permanent pain relief.

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Section: Discussionmentioning

confidence: 99%

Transcatheter arterial embolization for bone metastases from hepatocellular carcinoma

et al. 2001

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“…Such bone metastases have also been observed in patients with renal cell carcinoma and thyroid carcinoma. 22,23 In this study, the most observed anatomical metastatic regions were spine, followed by thorax and pelvis while the most observed sites with FN results on BS were the lower extremity, spine, and pelvis. These findings were compatible with those from previous reports.…”

Section: Discussionmentioning

confidence: 56%

“…It has been reported that bone metastases from HCC are often osteolytic and without obvious new bone formation. 3,22,23 This usually results in low Tc-99m MDP uptake and low sensitivity of BS. Such bone metastases have also been observed in patients with renal cell carcinoma and thyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…These findings were compatible with those from previous reports. 3,22,23 The high FN rate of the appendicular bone lesions may be attributed to that the lesions at extremities detected by BS are often interpreted as benign arthritis or traumatic lesions. Furthermore, the bony structure of the spine and pelvis is irregular and has a complex three-dimensional structure, which must be rendered into a two-dimensional image in planar BS study.…”

Section: Discussionmentioning

confidence: 99%

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High false negative rate of Tc-99m MDP whole-body bone scintigraphy in detecting skeletal metastases for patients with hepatoma

Chen

Lin

et al. 2012

Journal of the Formosan Medical Association

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High FN rate of Tc-99m MDP BS in detecting metastatic bone lesions for HCC patients was observed. In our opinion, careful history taking, meticulous examination, and a high index of suspicion are important for HCC patients with unexplained progressive pain in the musculoskeletal system. Even with negative results from Tc-99m MDP BS, the possibility of skeletal metastases cannot be indiscriminately excluded.

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“…Some studies with a limited number of patients have described the characteristics of bone metastasis from HCC, such as soft tissue formation (15)(16)(17)(18)(19). Kim (14) confirmed the characteristic finding of soft tissue formation at a bone metastasis from a primary hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 81%

The many, atypical presentations of musculoskeletal hepatocellular carcinoma (HCC) metastases

Elian

Gawad

2014

The Egyptian Journal of Radiology and Nuclear Medicine

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Purpose: To demonstrate many uncommon, non-classical clinical presentations of HCC that have been gathered from an endemic region in the Nile Basin. Patients and methods: We will highlight cases of high quality MDCT performed for various clinical symptoms not classically associated with advanced or metastatic HCC and the role of image-guided biopsy in diagnoses. These include: (a) gradual progressive weakness of lower limbs; (b) Retrosternal pain not responding to medications; (c) severe right hip pain; (d) progressive cheek swelling. These symptoms further corresponded to musculoskeletal abnormalities, not typically associated with HCC, including: (a) lumbar spinal cord compression by expansile vertebral body lesion; (b) direct invasion of chest wall; (c) large expansile metastasis of right acetabulum; (d) expansible rib lesions with rib destruction, (e) painful cheek swelling. Results: In numerous patients with a range of non-specific musculoskeletal complaints and various clinical presentations, the final diagnosis was HCC. The clinical presentation was dependent on uncommon skeletal deposits which were often expansile with the local effect of compression as underlying cause for the odd presentation. The important role of MDCT and Histopathological assessment in making correct diagnosis will be stressed. Conclusion: HCC can often grow silently and may present late with odd non-classic clinical presentation.

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Hepatocellular carcinoma with skeletal metastasis.

Cited by 31 publications

References 0 publications

Transcatheter arterial embolization for bone metastases from hepatocellular carcinoma

Transcatheter arterial embolization for bone metastases from hepatocellular carcinoma

High false negative rate of Tc-99m MDP whole-body bone scintigraphy in detecting skeletal metastases for patients with hepatoma

The many, atypical presentations of musculoskeletal hepatocellular carcinoma (HCC) metastases

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