Hepatocellular carcinoma with pharyngeal metastasis: Report of a case

Nagao, Yoshiko; Cho, Akihiro; Yamamoto, Hiroshi; Kainuma, Osamu; Gunji, Hisashi; Miyazaki, Akira; Ozaki, Daisuke

doi:10.1007/s00595-008-3790-y

Cited by 10 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…year after surgery for pharyngeal metastases (16)(17)(18)(19)(20). Our report is the second to describe solitary recurrence in the pharyngeal region after liver transplantation, and includes the longest surviving case of HCC with pharyngeal metastasis.…”

Section: Discussionmentioning

confidence: 78%

“…However, the rate of initial recurrence in multiple sites was reported to be about 40% (2,9,13) when systemic recurrence is promoted by circulating tumor cells; solitary recurrence is very rare, except at those sites. There are seven published cases of pharyngeal metastasis from HCC (14)(15)(16)(17)(18)(19)(20), which are summarized along with our case in Table 1. The reports all describe male patients with a median age of 70 years (range> 49-71 years).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term survival after resection of pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: case report and review of literature

Tohyama¹,

Sakamoto²,

Tamura³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:The most common sites of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been reported to be the liver, lung, bone, and adrenal glands, but there have also been many reports of cases of multiple recurrence. The prognosis after recurrence is poor, with reported median survival after recurrence of HCC ranging from 9 to 19 months. Here, we report a case of long-term survival after recurrence of pharyngeal metastasis following living-donor liver transplantation (LDLT) for HCC within the Milan criteria, by resection of the metastatic region and cervical lymph node dissection. Case presentation:A 47-year-old man with a Model End-stage Liver Disease (MELD) score of 11 underwent LDLT for HCC within the Milan criteria on liver cirrhosis associated with hepatitis B virus infection, with his 48-year-old elder brother as the living donor. One year and 10 months after liver transplantation, he visited a nearby hospital with a chief complaint of discomfort on swallowing. A pedunculated polyp was found in the hypopharynx, and biopsy revealed HCC metastasis. Pharyngeal polypectomy was performed, followed by neck lymph node dissection 2 years thereafter. Although recurrence subsequently occurred three times in the grafted liver, the patient is still alive 12 years 10 months after recurrence of pharyngeal metastasis. He is now a tumor-free outpatient taking sorafenib. Conclusion:It is necessary to recognize that the nasopharyngeal region is a potential site of HCC metastasis. Prognostic improvement can be expected with close follow-up, early detection, and multidisciplinary treatment including radical resection.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Long-term survival after resection of pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: case report and review of literature

Tohyama¹,

Sakamoto²,

Tamura³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Other metastatic sites were the adrenal gland, peritoneum, skin, brain, muscle, and pharynx. 23,24,27 The incidence of metastasis of HCC to the gallbladder is 2.7%-6.4% in autopsy series. 28,29 However, resected cases with metastasis of HCC to the gallbladder are even rarer.…”

Section: Discussionmentioning

confidence: 99%

Surgical resection for hepatocellular carcinoma with metastasis to the gallbladder: Report of a case

et al. 2011

View full text Add to dashboard Cite

A metastatic tumor of the gallbladder is rare. There have so far been no detailed reports of a resection of the metastasis of hepatocellular carcinoma (HCC) to the gallbladder published in the English literature. This report presents the case of a surgical resection for hepatocellular carcinoma with metastasis to the gallbladder. A 48-year-old woman consulted her primary care physician due to chest discomfort. Tumors in the liver and gallbladder were unexpectedly found and she was thus referred to this hospital. The radiologic studies showed two tumors. A round-shaped tumor, 30 mm in diameter, in the fossa of the gallbladder of the liver protruded into the lumen of the gallbladder, and a lobulated shaped tumor, measuring 13 mm, was in S5 of the liver. Angiography demonstrated that these tumors showed a pattern of early enhancement and washout. An en bloc resection of the gallbladder and the liver surrounding the gallbladder was performed, and the final diagnosis was moderately differentiated HCC in segment S5 with gallbladder metastasis. The patient is currently doing well 2 years after surgery, without any signs of recurrence. This case demonstrated that good clinical outcome could be achieved by performing surgery in HCC patients with metastasis to the gallbladder.

show abstract

“…However, the rate of initial recurrence in multiple sites was reported to be approximately 40% when systemic recurrence is promoted by circulating tumor cells; solitary recurrence is very rare, except at those sites [2,9,10,25]. There are seven published cases of pharyngeal metastasis from HCC, which are summarized along with our case in Table 1 [26][27][28][29][30][31][32]. The reports all describe male patients with a median age of 70 years (range 49-71 years).…”

Section: Discussionmentioning

confidence: 99%

Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review

et al. 2020

View full text Add to dashboard Cite

Background: The most common sites of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been reported to be the liver, lung, bone, and adrenal glands, but there have also been many reports of cases of multiple recurrence. The prognosis after recurrence is poor, with reported median survival after recurrence of HCC ranging from 9 to 19 months. Here, we report a case of long-term survival after recurrence of pharyngeal metastasis following living-donor liver transplantation (LDLT) for HCC within the Milan criteria, by resection of the metastatic region and cervical lymph node dissection. Case presentation: A 47-year-old man with a Model End-stage Liver Disease (MELD) score of 11 underwent LDLT for HCC within the Milan criteria for liver cirrhosis associated with hepatitis B virus infection, with his 48-year-old elder brother as the living donor. One year and 10 months after liver transplantation, he visited a nearby hospital with a chief complaint of discomfort on swallowing. A pedunculated polyp was found in the hypopharynx, and biopsy revealed HCC metastasis. We performed pharyngeal polypectomy. Two years later, cervical lymph node metastasis appeared, and neck lymph node dissection was performed. Although recurrence subsequently occurred three times in the grafted liver, the patient is still alive 12 years and 10 months after recurrence of pharyngeal metastasis. He is now a tumor-free outpatient taking sorafenib. Conclusion: It is necessary to recognize that the nasopharyngeal region is a potential site of HCC metastasis. Prognostic improvement can be expected with close follow-up, early detection, and multidisciplinary treatment, including radical resection.

show abstract

Hepatocellular carcinoma with pharyngeal metastasis: Report of a case

Cited by 10 publications

References 10 publications

Long-term survival after resection of pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: case report and review of literature

Long-term survival after resection of pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: case report and review of literature

Surgical resection for hepatocellular carcinoma with metastasis to the gallbladder: Report of a case

Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review

Contact Info

Product

Resources

About