Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report

Atra, Ayad; Al-Asiri, Rizgullah H.; Wali, Sami; Al-Husseini, Hussa; Al-Bassas, A; Zimmermann, Arthur

doi:10.1016/j.anndiagpath.2005.12.005

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…In addition, microscopically, CCC of liver was similar to clear cell tumors from other sites including adrenal gland, kidney, ovary, lung, and pancreas (17,18), making it difficult to differentiate it from the metastatic CCC of the liver. Murakata et al (19) reported that the hepatocyte antibody (DAKO) IHC staining distinguished primary CCC of liver from other clear cell malignancies with a sensitivity of 90% and specificity of 100%.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

et al. 2018

Chinese Journal of Cancer Research

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Section: Discussionmentioning

confidence: 99%

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

et al. 2018

Chinese Journal of Cancer Research

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“…This variant was proposed in a case report that showed a well-differentiated hepatocellular carcinoma with numerous syncytial type multinuclear giant cells similar to those seen in infantile giant cell hepatitis [ 108 ]. Other areas of the tumor showed smaller, less-differentiated nests of tumor cells in a desmoplastic background.…”

Section: Hepatocellular Carcinoma With Syncytial Giant Cellsmentioning

confidence: 93%

Hepatocellular Carcinoma

Torbenson¹

2015

Surgical Pathology of Liver Tumors

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Hepatocellular carcinoma is the most common primary malignant tumor of the liver. Although usually morphologically distinct, hepatocellular carcinomas can demonstrate various histologic patterns, which sometimes create diagnostic challenges for the surgical pathologist. In addition, a number of subtypes are discussed in this chapter, along with typical hepatocellular carcinoma. This chapter examines the clinical, gross, and microscopic features of hepatocellular carcinoma and its variants with illustrated examples. The differential diagnosis of hepatocellular carcinoma is also covered, with a detailed discussion of the various special stains used in the diagnosis of hepatocellular carcinoma and their respective utilities and limitations. Important prognostic factors, including grading of hepatocellular carcinoma, are also reviewed.

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“…A marked contribution of large syncytial giant cells was found in an hepatocellular carcinoma of an infant who presented with features of Cushing's syndrome due to bilateral adrenal hyperplasia (Atra et al 2007). This patient was a 9-month-old girl with bilateral nodular hyperplasia of the adrenal glands and a cystic lesion in the left ovary that in addition showed a 5 cm-sized mass in the right liver lobe.…”

Section: Pediatric Syncytial Giant Cell Hepatocellular Carcinomamentioning

confidence: 83%

Variants of Hepatocellular Carcinoma

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Few hepatocellular carcinomas (HCC) show a morphologic pattern that deviates from the histology of ordinary HCC or established variants thereof, treated in detail in other chapters. Rare tumors show peliotic change with a presence of blood-filled spaces lacking an endothelial lining (peliotic HCC). One variant of HCC is characterized by multinuclear tumor cells resembling syncytial cells in giant cell hepatitis (syncytial giant cell HCC). This unusual neoplasm occurs both in the pediatric age group and in adults. Cells with a smooth chromophobic cytoplasm and clusters of cells with anaplastic changes are diagnostic features of the rare chromophobe HCC. HCCs with strongly eosinophilic and granular cells form the oxyphilic and oncocytic variants of HCC, the latter having increased number of mitochondria, similar to oncocytic tumors in other organs. Very rare HCCs are pigmented due to the accumulation of a Dubin-Johnson-like pigment. Other very rare variants of HCC include pleomorphic giant cell-rich HCC, spindle cell HCC, and ossifying HCC.

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Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report

Cited by 16 publications

References 11 publications

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Hepatocellular Carcinoma

Variants of Hepatocellular Carcinoma

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