Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Famularo, Simone; Donadon, Matteo; Cipriani, Federica; Ardito, Francesco; Carissimi, Francesca; Perri, Pasquale; Iaria, Maurizio; Dominioni, Tommaso; Zanello, Matteo; Conci, Simone; Molfino, Sarah; LaBarba, Giuliano; Ferrari, Cecilia; Germani, Paola; Patauner, Stefan; Pinotti, Enrico; Lodo, E.; Garatti, Marco; Sciannamea, Ivano; Troci, Albert; Conticchio, Maria; Floridi, Antonio; Chiarelli, Marco; Fumagalli, Luca; Méméo, Riccardo; Crespi, Michele; Antonucci, Adelmo; Zimmitti, Giuseppe; Zanus, Giacomo; Zago, Mauro; Frena, Antonio; Tarchi, Paola; Griseri, G.; Ercolani, Giorgio; Baiocchi, Gian Luca; Ruzzenente, Andrea; Jovine, Elio; Maestri, Marcello; Dallavalle, R; Grazi, Gian Luca; Giuliante, Felice; Aldrighetti, Luca; Torzilli, Guido; Romano, Fabrizio

doi:10.1007/s13304-020-00733-6

Cited by 18 publications

(12 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…30 In accordance with literature, postoperative outcomes observed after liver resection for HCC and biliary cancer are significantly worse in elderly patients. 8,[31][32][33][34][35][36][37][38] Long-term survival after resection of HCC or biliary cancer was not different in elderly patients. 36,[38][39][40] The nationwide data form this study and previous reports show that liver resection of primary and secondary liver tumours in elderly patients can be performed with relatively low mortality.…”

Section: Discussionmentioning

confidence: 94%

Short-term postoperative outcomes after liver resection in the elderly patient: a nationwide population-based study

Elfrink

Kok

Dulk

et al. 2021

HPB

View full text Add to dashboard Cite

Background: Liver resection is high-risk surgery in particular in elderly patients. The aim of this study was to explore postoperative outcomes after liver resection in elderly patients.Methods: In this nationwide study, all patients who underwent liver resection for primary and secondary liver tumours in the Netherlands between 2014 and 2019 were included. Age groups were composed as younger than 70 (70-), between 70 and 80 (septuagenarians), and 80 years or older (octogenarians).Proportion of liver resections per age group and 30-day major morbidity and 30-day mortality were assessed. Results: In total, 6587 patients were included of whom 4023 (58.9%) were younger than 70, 2135 (32.4%) were septuagenarians and 429 (6.5%) were octogenarians. The proportion of septuagenarians increased during the study period (aOR:1.06, CI:1.02-1.09, p < 0.001). Thirty-day major morbidity was higher in septuagenarians (11%) and octogenarians (12%) compared to younger patients (9%, p = 0.049). Thirty-day mortality was higher in septuagenarians (4%) and octogenarians (4%) compared to younger patients (2%, p < 0.001). Cardiopulmonary complications occurred more frequently with higher age, liver-specific complications did not. Higher age was associated with higher 30-day morbidity and 30-day mortality in multivariable logistic regression. Conclusion: Thirty-day major morbidity and 30-day mortality are higher after liver resection in elderly patients, attributed mainly to non-surgical cardiopulmonary complications.

show abstract

Section: Discussionmentioning

confidence: 94%

Short-term postoperative outcomes after liver resection in the elderly patient: a nationwide population-based study

Elfrink

Kok

Dulk

et al. 2021

HPB

View full text Add to dashboard Cite

show abstract

“…This study evaluated patients enrolled in a multi-institutional Register of HCC by the He.RC.O.Le.S. Group, which is composed of 30 Italian liver surgery centers [16].…”

Section: Patients and Study Designmentioning

confidence: 99%

Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC

Conci

Cipriani

Donadon

et al. 2022

European Journal of Surgical Oncology

Self Cite

View full text Add to dashboard Cite

“…LR is a nonprojectable therapeutic option that includes the risk of cancer progression pending a suitable organ[ 10 ]. Nevertheless, LR is associated with considerable postoperative morbidity and mortality, and the early and late recurrence rates after this surgical approach remain high[ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Rethinking the Barcelona clinic liver cancer guidelines: Intermediate stage and Child-Pugh B patients are suitable for surgery?

Romano¹,

Chiarelli²,

Garancini³

et al. 2021

WJG

Self Cite

View full text Add to dashboard Cite

According to Barcelona Clinic Liver Cancer recommendations, intermediate stage hepatocellular carcinomas (stage B) are excluded from liver resection and are referred to palliative treatment. Moreover, Child-Pugh B patients are not usually candidates for liver resection. However, many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection, maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function. Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification, and this treatment gives good results in the setting of multinodular, large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis. In this review we explore this controversial topic, and we show through the literature analysis how liver resection may improve the short- and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients. However, other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection.

show abstract

Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Cited by 18 publications

References 53 publications

Short-term postoperative outcomes after liver resection in the elderly patient: a nationwide population-based study

Short-term postoperative outcomes after liver resection in the elderly patient: a nationwide population-based study

Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC

Rethinking the Barcelona clinic liver cancer guidelines: Intermediate stage and Child-Pugh B patients are suitable for surgery?

Contact Info

Product

Resources

About