Hepatocellular Carcinoma: Regional Therapy with a Magnetic Targeted Carrier Bound to Doxorubicin in a Dual MR Imaging/ Conventional Angiography Suite—Initial Experience with Four Patients

Wilson, Mark W.; Kerlan, Robert K.; Fidelman, Nicholas; Venook, Alan P.; LaBerge, Jeanne M.; Koda, Joy E.; Gordon, Roy L.

doi:10.1148/radiol.2301021493

Cited by 184 publications

(119 citation statements)

References 15 publications

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“…These include techniques that rely on magnetic targeting using, for example, magnetic microparticles (recently reviewed by Dobson [6] and by Pankhurst et al [21]) and magnetically tagged macrophages (Muthana et al [20]) as the transport vehicle. In the context of the former, and older technology, there have been two Phase I/II clinical trials [18,28] in addition to numerous in vivo studies (e.g. [2,3,19]).…”

Section: Introductionmentioning

confidence: 99%

Particle trapping by an external body force in the limit of large Peclet number: applications to magnetic targeting in the blood flow

Richardson¹,

Kaouri

Byrne

2010

Eur. J. Appl. Math

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Motivated by the technology of magnetically targeted drug and gene delivery, in which a magnetic field is used to direct magnetic carrier particles from the circulation to a target site, we develop a continuum model for the motion of particles (magnetic carriers) subject to an external body force (magnetic field) in a flow of a concentrated suspension of a species of neutrally buoyant particles (blood). An advection-diffusion equation describes the evolution of the carrier particles as they advect in the flow under the action of an external body force, and diffuse as a result of random interactions with the suspension of neutrally buoyant particles (shear-induced diffusion). The model is analysed for the case in which there is steady Poiseuille flow in a cylindrical vessel, the diffusive effects are weak and there is weak carrier uptake along the walls of the vessel. The method of matched asymptotic expansions is used to show that carriers are concentrated in a boundary layer along the vessel wall and, further, that there is a carrier flux along this layer which results in a sub-layer, along one side of the vessel, in which carriers are even more highly concentrated. Three distinguished limits are identified: they correspond to cases for which (i) the force is sufficiently weak that most particles move through the vessel without entering the boundary layers along the walls of the vessel and (ii) and (iii) to a force which is sufficiently strong that a significant fraction of the particles enter the boundary layers and, depending upon the carrier absorption from the vessel walls, there is insignificant/significant axial carrier flux in these layers.

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Section: Introductionmentioning

confidence: 99%

Particle trapping by an external body force in the limit of large Peclet number: applications to magnetic targeting in the blood flow

Richardson¹,

Kaouri

Byrne

2010

Eur. J. Appl. Math

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“…The particles were directed to the tumour sites by magnets and monitored by MRI image. The results showed the drug had treated between 64 and 91% of tumour volume (Wilson et al, 2004).…”

Section: Magnetic Target Drug Delivery and Magnetic Guided Gene Transmentioning

confidence: 99%

Coating Nanomagnetic Particles for Biomedical Applications

Andrade¹,

Ferreira²,

Fabris³

et al. 2011

Biomedical Engineering - Frontiers and Challenges

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“…In this study, epirubicine was complexed to nanoparticles on the basis of electrostatic interactions between phosphate groups bound to the surface of particles and amino sugars present within the drug. Similarly, few more clinical trials have been performed with promising results [96,97], thus promoting magnetic nanoparticles as another tool for treatment of variety of diseases. The future for drug delivery systems is expected to be bright, even if significant obstacles still have to be overcome [69].…”

Section: Drug Deliverymentioning

confidence: 99%

Applying Nanotechnology to Human Health: Revolution in Biomedical Sciences

Shrivastava

Dash

2009

Journal of Nanotechnology

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Recent research on biosystems at the nanoscale has created one of the most dynamic science and technology domains at the confluence of physical sciences, molecular engineering, biology, biotechnology, and medicine. This domain includes better understanding of living and thinking systems, revolutionary biotechnology processes, synthesis of new drugs and their targeted delivery, regenerative medicine, neuromorphic engineering, and developing a sustainable environment. Nanobiosystems research is a priority in many countries and its relevance within nanotechnology is expected to increase in the future. The realisation that the nanoscale has certain properties needed to solve important medical challenges and cater to unmet medical needs is driving nanomedical research. The present review explores the significance of nanoscience and latest nanotechnologies for human health. Addressing the associated opportunities, the review also suggests how to manage far-reaching developments in these areas.

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Hepatocellular Carcinoma: Regional Therapy with a Magnetic Targeted Carrier Bound to Doxorubicin in a Dual MR Imaging/ Conventional Angiography Suite—Initial Experience with Four Patients

Cited by 184 publications

References 15 publications

Particle trapping by an external body force in the limit of large Peclet number: applications to magnetic targeting in the blood flow

Particle trapping by an external body force in the limit of large Peclet number: applications to magnetic targeting in the blood flow

Coating Nanomagnetic Particles for Biomedical Applications

Applying Nanotechnology to Human Health: Revolution in Biomedical Sciences

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