Hepatocellular carcinoma invading the gallbladder: CT, arteriography and MRI findings

Tamura, Shozo; Kihara, Yasushi; Kakitsubata, Y; Kakitsubata, Sachiko; Iwata, Koji; Higashi, Hidefumi; Setoguchi, Toshiaki; Watanabe, Kentaro

doi:10.1016/0899-7071(93)90048-r

Cited by 9 publications

(5 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

“…There are four reported cases of HCC that invaded the gallbladder 25–28 . Three of the patients did not have liver cirrhosis and the clinical diagnosis was gallbladder carcinoma that had invaded the liver 26–28 . In at least two of those cases, 27,28 the patients were not infected with hepatitis B or C virus and did not have inflammation and/or fibrosis in their non‐HCC liver.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27][28] Three of the patients did not have liver cirrhosis and the clinical diagnosis was gallbladder carcinoma that had invaded the liver. [26][27][28] In at least two of those cases, 27,28 the patients were not infected with hepatitis B or C virus and did not have inflammation and/or fibrosis in their non-HCC liver. Furthermore, in those patients, lymph node metastasis was detected at the hepatoduodenal ligament, which is frequently seen in gallbladder cancer and not in liver cancer.…”

Section: Figurementioning

confidence: 99%

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Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature

Sakamoto

Monobe²,

Kouno

et al. 2003

Pathology International

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A rare case of hepatoid adenocarcinoma (HAC) of the gallbladder occurred in a 72-year-old man who presented with abdominal pain and was admitted to hospital. Ultrasonography and computed tomography revealed a mass in the gallbladder, multiple nodules in the liver and enlargement of the lymph nodes. He was diagnosed as having a gallbladder carcinoma with multiple liver and lymph node metastases. Cholecystectomy and partial hepatectomy was performed. Histologically, most of the mass in the gallbladder was composed of cells with eosinophilic cyto-plasm arranged in a trabecular pattern, which resembled hepatocellular carcinoma, but there was a component of well-differentiated adenocarcinoma in the mucosa. Immunohistochemically these hepatoid tumor cells were positive for Hepatocyte (Hepatocyte Paraffin 1: Hep Par1), which is considered highly sensitive and highly specific for hepatocyte differentiation. Based on these findings, this case was diagnosed as hepatoid adenocarcinoma of the gallbladder, which is generally a vary rare neoplasm in the literature, but should be included in the differential diagnosis of a mass in the gallbladder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature

Sakamoto

Monobe²,

Kouno

et al. 2003

Pathology International

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“…rence. Autopsy studies report the frequency of GB metastasis as approximately 5%, [13][14][15][16][17] with the clinical features of GB metastasis mostly described as advanced stage with multiple metastasis sites.…”

Section: G B Metastasis From Hcc Is a Rare Clinical Occur-mentioning

confidence: 99%

Isolated metastasis to the gallbladder from hepatocellular carcinoma

Murakami¹,

Kobayashi²,

Marubashi³

et al. 2010

Hepatology Research

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“…Advanced HCC often spreads as intrahepatic metastases, while extrahepatic metastasis is occasionally seen in the lung, bone, adrenal gland, and lymph nodes [4] . Reports of gallbladder invasion or metastasis from HCC are rare even in advanced tumors [1] , [2] , [5] . As there is no peritoneum between the gallbladder and the liver fossa, gallbladder cancer easily invades the liver; however, HCC seldom invades the gallbladder because it rarely destroys the muscle layer or collagen fibres of the gallbladder wall [2] .…”

Section: Discussionmentioning

confidence: 99%

A case of clear cell-hepatocellular carcinoma accidentally found in the gallbladder wall after laparoscopic resection of gallbladder empyema: Beware of the liver bed

Ghashir

Allawi

Rathinavelu

et al. 2023

International Journal of Surgery Case Reports

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Hepatocellular carcinoma invading the gallbladder: CT, arteriography and MRI findings

Cited by 9 publications

References 6 publications

Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature

Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature

Isolated metastasis to the gallbladder from hepatocellular carcinoma

A case of clear cell-hepatocellular carcinoma accidentally found in the gallbladder wall after laparoscopic resection of gallbladder empyema: Beware of the liver bed

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