2019
DOI: 10.20517/2394-5079.2018.114
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Hepatocellular carcinoma in non-alcoholic fatty liver disease with and without cirrhosis

Abstract: Non-alcoholic fatty liver disease has become the leading chronic liver disease in the developed world, with a prevalence of 6%-35%. Its pathological spectrum ranges from simple steatosis (non-alcoholic fatty liver) to different degrees of inflammation and liver cell damage [non-alcoholic steatohepatitis (NASH)]. NASH has gained attention in recent years because of its association with hepatocellular carcinoma (HCC). Although the occurrence of HCC is more frequent in the presence of cirrhosis, studies have show… Show more

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Cited by 6 publications
(2 citation statements)
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“…Liver cirrhosis and HCC are complications of NASH when this condition is not properly treated. It is interesting to note that HCC is reported also in non-cirrhotic NASH patients [15].…”
Section: Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohe...mentioning
confidence: 99%
“…Liver cirrhosis and HCC are complications of NASH when this condition is not properly treated. It is interesting to note that HCC is reported also in non-cirrhotic NASH patients [15].…”
Section: Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohe...mentioning
confidence: 99%
“…Furthermore, being frequently associated with type II diabetes mellitus, NAFLD is a direct effect of peripheral insulin resistance . (4) Even though over the years numerous studies covered the pathophysiology of NAFLD/NASH, there is a multitude of mechanisms that remain unknown or poorly understood. These two physiological activities of adiponutrin suggest its double metabolic roles, as a catabolic lipase, which catalyses the breakdown of triglycerides into fatty acids and glycerol, and also as an anabolic lipogenic enzyme .…”
Section: Etiology and Pathophysiologymentioning
confidence: 99%