HEPATOCELLULAR CARCINOMA IN CAPTIVE SLENDER TAILED MEERKATS (<i>SURICATA SURICATTA</i>): 5 CASES

Marrow, Judilee C.; Basu, Puja; Walsh, Timothy; Siegal-Willott, Jessica L.

doi:10.1638/2013-0142r.1

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…Reported neoplasms in these groups include lymphoma ( Fig. 12.3), carcinomas of the urinary bladder, gastrointestinal tract (including anal sac glands), mammary gland, hepatobiliary, pulmonary, and renal systems (Aihara, 2009;Bjornson et al, 1999;Boonsri et al, 2013;Childs-Sanford et al, 2005;Chu et al, 2012;Dadone et al, 2014;Dawood, 2012;Effron et al, 1977;Goodnight et al, 2013;Hamir and Rupprecht, 1995;Hamir et al, , 2008Howard et al, 2007;Klaphake et al, 2005;Lombard and Witte, 1959;Marrow et al, 2014;Montali, 1980;Singh et al, 2005;Singleton et al, 2007;Thompson et al, 2016;Wadsworth et al, 1982;Wang et al, 2001). A single case of uterine adenocarcinoma in a captive coati associated with implantation of the contraceptive melengestrol acetate has also been reported (Chittick et al, 2001).…”

Section: Neoplasticmentioning

confidence: 99%

Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae

Church

Terio

Keel

2018

Pathology of Wildlife and Zoo Animals

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Section: Neoplasticmentioning

confidence: 99%

Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae

Church

Terio

Keel

2018

Pathology of Wildlife and Zoo Animals

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“… 2013 ; Marrow et al. 2014 ). Other non-infectious causes of death or euthanasia of captive meerkats include traumatic events due to con-specific attacks, especially during feeding times (Tomczyk and Zieliński 2021 ) and heart valvular dysplasia (Chai et al.…”

Section: Introductionmentioning

confidence: 99%

Pathology and causes of death in captive meerkats ( Suricata suricatta )

Martí-García

Priestnall

Suárez‐Bonnet

2023

Veterinary Quarterly

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Background Meerkats ( Suricata suricatta ) are endemic carnivores of southern Africa and, although currently listed as ‘least concern’ by the International Union for Conservation of Nature (IUCN) red list, there is evidence of a significant decrease in wild populations mainly attributed to effects of climate change. Little is known about diseases associated with mortality in captive meerkats. Aim To characterise macroscopic and microscopic lesions that accounted for the death or euthanasia in a series of captive meerkats. Material and methods Eight captive meerkats submitted for post-mortem examination between 2018 and 2022. Results Three animals died unexpectedly without clinical signs, 2 exhibited neurological signs, 2 collapsed after con-specific fighting and 1 showed gastrointestinal signs. Common pathological findings of this study that may be related to the death of captive meerkats included foreign bodies (trichobezoars or plastic materials) within the alimentary tract, traumatic penetrating injuries or starvation associated with abnormal social behaviours (bullying and con-specific attacks), verminous pneumonia and systemic atherosclerosis. Common incidental findings included pulmonary edema and congestion, cholesterol granulomas, pulmonary adenomas and vertebral spondylosis. Conclusions Non-infectious diseases outreach infectious diseases as causes of mortality in captive meerkats including, foreign bodies within the alimentary tract, con-specific attacks and systemic atherosclerosis, which is described for the first time. These data should raise concern about appropriate husbandry (e.g. environmental enrichment, cleaning of facilities and diet formulation) by zookeepers and emphasise the need for further study of meerkat mortality in both captive and wild populations.

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“…In zoo animals, primary hepatic tumors, such as HCC and hepatocellular adenoma, have been reported in lions, pangolins, meerkats, and otters [ 3 , 18 , 22 ]. Bats are known to have a low cancer incidence, with only a few reports of limited cases, such as leiomyosarcoma, fibrosarcoma, and HCC.…”

mentioning

confidence: 99%

Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>)

KAWAGUCHI,

FUKE,

NUEANGPHUET

et al. 2024

The Journal of Veterinary Medical Science

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After an Egyptian fruit bat ( Rousettus aegyptiacus ) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.

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HEPATOCELLULAR CARCINOMA IN CAPTIVE SLENDER TAILED MEERKATS (SURICATA SURICATTA): 5 CASES

Cited by 8 publications

References 24 publications

Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae

Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae

Pathology and causes of death in captive meerkats ( Suricata suricatta )

Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>)

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