Hepatocellular carcinoma in a hepatitis C patient with sustained viral response and no fibrosis

Tabibian, James H.; Landaverde, Carmen; Winn, Julie; Geller, Stephen A.; Nissen, Nicholas N.

doi:10.1016/s1665-2681(19)31814-9

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Our observed case of cholangiocarcinoma is the second case to have been described in SVR [30], but it was not unexpected, as the association between HCV and cholangiocarcinoma has been well-established [31]. All four PLC occurred in patients who had cirrhosis previously and despite a significant improvement of fibrosis in two, as already described once [32]. These observations offer a major argument for treating patients before they develop AdF.…”

Section: Impact Of Svr On Plc Incidencesupporting

confidence: 76%

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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C

Poynard¹,

Moussalli²,

Munteanu³

et al. 2013

Journal of Hepatology

141

102

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Section: Impact Of Svr On Plc Incidencesupporting

confidence: 76%

“…The persistence of these features could explain the late onset of complications [32,36]. Aging patients could also develop hepatic insufficiency and portal hypertension, particularly if capillarization is associated with metabolic factors or heavy alcohol consumption.…”

Section: Regression Of Fibrosis Inmentioning

confidence: 99%

Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C

Poynard¹,

Moussalli²,

Munteanu³

et al. 2013

Journal of Hepatology

141

102

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“…The incidence of HCC in patients without advanced hepatic fibrosis, years after treatment for HCV and with SVR, has been reported in Asian patients, particularly in Japanese ones 1 , 9 , 12 , 18 , where HCV infection is endemic and the prevalence of HCC is high. In the Occident, we found few similar cases published in the literature 3 , 19 , one of the reasons why we deem important to present this case.…”

Section: Discussionmentioning

confidence: 76%

Hepatocellular Carcinoma in a Non-Cirrhotic Patient With Sustained Virological Response After Hepatitis C Treatment

Mattos

Marcon

Araújo

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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Chronic infection by hepatitis C virus (HCV) is one of the main risk factors for the development of liver cirrhosis and hepatocellular carcinoma. However, the emergence of hepatocellular carcinoma (HCC) in non-cirrhotic HCV patients, especially after sustained virological response (SVR) is an unusual event. Recently, it has been suggested that HCV genotype 3 may have a particular oncogenic mechanism, but the factors involved in these cases as well as the profile of these patients are still not fully understood. Thus, we present the case of a non-cirrhotic fifty-year-old male with HCV infection, genotype 3a, who developed HCC two years after treatment with pegylated-interferon and ribavirin, with SVR, in Brazil.

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“…However, emerging evidence suggests that HCV may have a direct role in hepatocarcinogenesis as well and several studies have documented HCC developing in HCV patients without cirrhosis. 13-15 .…”

Section: Discussionmentioning

confidence: 99%

Cirrhosis Is Present in Most Patients With Hepatitis B and Hepatocellular Carcinoma

Yang

Kim

Coelho

et al. 2011

Clinical Gastroenterology and Hepatology

230

155

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Background& Aims There is not much data available about the prevalence or effects of cirrhosis in patients with hepatocellular carcinoma (HCC) from viral hepatitis. We compared patients with HCC and hepatitis B virus (HBV) or hepatitis C virus (HCV) infections to determine the proportions of cirrhosis in each group, virologic and tumor characteristics, and overall survival. Methods This analysis includes patients with HBV (n=64) or HCV (n=118) infection who were diagnosed with HCC at the Mayo Clinic in Rochester MN from 1994 to 2008; groups were matched for age and sex. The diagnosis of cirrhosis was based on histology and, if histologic information was insufficient or unavailable, clinical indicators that included ascites or varices, thrombocytopenia or splenomegaly, and radiographic configuration of cirrhosis. Virologic characteristics, tumor stage, and patient survival were also assessed. Results The prevalence of histologic cirrhosis was 88% among patients with HBV infection and 93% among those with HCV infection (P=0.46). When the most inclusive criteria for cirrhosis were applied, cirrhosis was present in 94% of patients with HBV and 97% with HCV (P=0.24). Among HCV patients, 5.2% were negative for HCV RNA following antiviral treatment; 63.4% of HBV patients had HBV DNA < 2000 u/ml with or without treatment. Patients with HBV tended to have less surveillance and more advanced stages of HCC, without differences in survival from those with HCV infection (P=0.75). Conclusion Most patients with HCC and chronic viral hepatitis had evidence of cirrhosis, including those with HBV infection and those without active viral replication.

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Hepatocellular carcinoma in a hepatitis C patient with sustained viral response and no fibrosis

Cited by 5 publications

References 23 publications

Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C

Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C

Hepatocellular Carcinoma in a Non-Cirrhotic Patient With Sustained Virological Response After Hepatitis C Treatment

Cirrhosis Is Present in Most Patients With Hepatitis B and Hepatocellular Carcinoma

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