Hepatocellular carcinoma diagnosis and surveillance: Socioeconomic factors don’t seem to matter, unless you are an immigrant

Ashhab, Ashraf A.; Rodin, Holly; Powell, Jesse; Debes, José D.

doi:10.1016/j.jhep.2017.05.003

Cited by 14 publications

(10 citation statements)

References 7 publications

(13 reference statements)

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“…We appreciate the correspondence of Mohammed et al regarding our article on socioeconomic variables and hepatocellular carcinoma (HCC). 1 Unlike our study, Mohammed et al found significant associations between socioeconomic variables and access to different treatment options for HCC in a small study (79 cases) in England. We believe a few differences are important to remark upon: a) In our study, we did find differences when we distinguished individuals born in the United States (US) or outside the US.…”

contrasting

confidence: 99%

Reply to: “Socio-economic deprivation significantly impacts clinical management and survival in hepatocellular carcinoma”

Ashhab

Rodin

Debes

2018

Journal of Hepatology

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contrasting

confidence: 99%

Reply to: “Socio-economic deprivation significantly impacts clinical management and survival in hepatocellular carcinoma”

Ashhab

Rodin

Debes

2018

Journal of Hepatology

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“…HCC is often secondary to chronic liver cirrhosis, and various risk factors have been identified, such as chronic hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, autoimmune hepatitis, alcohol abuse, and several metabolic diseases [ 2 , 3 ]. Current therapeutic strategies for HCC, such as surgical resection, liver transplantation, and radiofrequency ablation, have been widely used and improved, but the long-term survival rate of HCC is still unsatisfactory due to the high percentage of cases that are at an advanced stage at diagnosis and the high recurrence rate after surgical resection [ 4 , 5 ]. Only 2 first-line therapeutic drugs, the oral multikinase inhibitors sorafenib and lenvatinib, have shown clinical benefits in patients with advanced HCC [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

et al. 2020

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Background Orderly G2/M transition in the cell cycle is controlled by the cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships with immune infiltration in hepatocellular carcinoma (HCC). Material/Methods The transcriptional data and the epigenetic and genetic alterations of CDK1 , CCNB1 , and CCNB2 , as well as their impacts on prognosis in HCC patients, were identified using multiple databases. The correlations between expression of these genes and immune infiltration in HCC were then explored using the TIMER database. Results Overall, mRNA expression of CDK1 , CCNB1 , and CCNB2 was up-regulated in various tumor tissues including HCC. Higher expression of these genes was associated with poorer prognosis in HCC patients. Lower promoter methylation of these genes might cause higher expression levels in tumor tissues of HCC. Genetic alterations and several methylated-CpG sites in these genes were significantly associated with survival. Notably, expression levels of CDK1 , CCNB1 , and CCNB2 were positively correlated with infiltrating levels of CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells in HCC. In addition, significant correlations between the expression of these genes and various immune markers in HCC, such as PD-1, PDL-1, and CTLA-4, were also observed. Conclusions CDK1 , CCNB1 , and CCNB2 are potential prognostic biomarkers and associated with immune cell infiltration in HCC. The genes may be utilized to predict the reaction of immunotherapy. Combining inhibitors of these genes with immunotherapy may improve the survival time of HCC patients.

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“…Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide 1 . Despite recent advances in the treatment of HCC in surgery, chemotherapy and biologics, it still has a poor prognosis due to tumor metastatic and chemoresistant 2 , 3 . Tumorigenesis is a complex process involving multiple genetic changes and ultimately leading to the malignant transformation 4 .…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway

et al. 2018

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Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) had malfunctioning roles in the development of human cancers. The present study aimed to investigate the role of lncRNA small nucleolar RNA host gene 5 (SNHG5) in hepatocellular carcinoma (HCC) progression using human tissues and cell lines. The quantitative real-time PCR results showed that SNHG5 was up-regulated in both HCC tissues and hepatoma cell lines and was closely associated with tumor size, hepatitis B virus infection, histologic grade, TNM stage, and portal vein tumor thrombus (PVTT) in HCC patients. Knockdown of SNHG5 induced apoptosis and repressed cell cycle progression, cell growth, and metastasis in hepatoma cell lines, whereas overexpression of SNHG5 had the opposite effects. In vivo functional assay, xenograft tumors grown from SNHG5-knockdown cells had smaller mean volumes than the tumors grown from negative control cells. Further investigations showed that SNHG5 may act as a competing endogenous RNA by competitively binding miR-26a-5p and thereby modulating the derepression of downstream target GSK3β, which were further confirmed by luciferase reporter assay. Functionally, SNHG5 promotes tumor growth and metastasis by activating Wnt/β-catenin pathway and inducing epithelial to mesenchymal transition (EMT). Taken together, SNHG5 promotes HCC progression by competitively binding miR-26a-5p and regulating GSK3β and Wnt/β-catenin signal pathway.

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Hepatocellular carcinoma diagnosis and surveillance: Socioeconomic factors don’t seem to matter, unless you are an immigrant

Cited by 14 publications

References 7 publications

Reply to: “Socio-economic deprivation significantly impacts clinical management and survival in hepatocellular carcinoma”

Reply to: “Socio-economic deprivation significantly impacts clinical management and survival in hepatocellular carcinoma”

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway

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