Hepatocellular carcinoma: correlation of CT, angiographic, and histopathologic findings.

Honda, Hiroshi; Ochiai, Koji; Adachi, Eisuke; Yasumori, Kotaro; Hayashi, Takamoto; Kawashima, Akira; Fukuya, Tatsuro; Gibo, Masaki; Murakami, Takashi; Tsuneyoshi, Masazumi

doi:10.1148/radiology.189.3.8234716

Cited by 59 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The diagnosis of HCC was made based on the presence of both characteristic imaging findings and increases in serum tumor markers; the diagnostic criteria for HCC via imaging was based on previous reports of hyperattenuation at the arterial phase and hypoattenuation at the portal phase in the tumor, determined by dynamic computed tomography and/or magnetic resonance imaging [13]. In addition, increases in serum tumor markers such as α-fetoprotein, des-γ-carboxyprothrombin, or Lens culinaris agglutinin-reactive fraction of α-fetoprotein, were also required for the diagnosis of HCC.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Non-B Non-C Hepatocellular Carcinoma: A Single-Center Retrospective Study

et al. 2011

View full text Add to dashboard Cite

Background/Aims: To clarify risk factors and clinical features of both hepatitis B surface antigen and anti-HCV negative hepatocellular carcinoma (NBNC-HCC). Methods: HCC patients (n = 1,109) diagnosed at a single center were categorized based on the presence of serum hepatitis B surface antigen and HCVAb. Clinical characteristics of 127 NBNC-HCC patients were evaluated. Results: NBNC-HCC patients were stratified as those with alcoholic liver disease (ALD-HCC, n = 42) and alcohol-unrelated liver disease (non-ALD-HCC, n = 85). Compared with the ALD-HCC group, the non-ALD-HCC group had a higher prevalence of diabetes (p = 0.015), larger tumor size (p = 0.007), and higher tumor marker levels (p = 0.014). Liver function results were significantly worse in ALD-HCC than in non-ALD-HCC. Although the ALD-HCC group had a higher tendency toward recurrence than the non-ALD-HCC group, survival rates were similar between groups (p = 0.352). Conclusion: Alcohol consumption was the most common etiologic factor for NBNC-HCC, and diabetes may be related to the development of HCC in non-ALD-HCC patients. Non-ALD-HCC tended to be diagnosed at a more advanced stage, whereas liver function was worse, and tumor recurrence rate was higher in ALD-HCC patients. Further examination of the risk factors and establishment of a precise surveillance system are necessary for early diagnosis and the development of curative therapies for NBNC-HCC.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Non-B Non-C Hepatocellular Carcinoma: A Single-Center Retrospective Study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Diagnostic criteria for HCC via imaging was based on previous reports of hyperattenuation at the arterial phase, hypoattenuation at the portal phase in dynamic CT (section thickness ¼ 5 -8 mm) or MRI, and tumour stain on angiography (Honda et al, 1993). The remaining 16 patients with hepatic masses who did not satisfy the above criteria underwent ultrasound (US)-guided fine-needle biopsy with histologically confirmed HCC.…”

Section: Diagnosismentioning

confidence: 99%

Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis

Nouso¹,

Ito

Kuwaki

et al. 2008

Br J Cancer

View full text Add to dashboard Cite

The aim of this study is to elucidate the prognostic factors and the treatment effect on survival in hepatocellular carcinoma (HCC) patients with Child C cirrhosis. Out of 3330 newly discovered HCC patients, 157 consecutive HCC individuals with Child C cirrhosis were enrolled. The prognostic factors were examined by Cox proportional hazards regression analysis and their survival was compared by propensity score-matched analysis. Multivariate analysis revealed that high serum bilirubin (43 mg dl À1 ), the presence of uncontrollable ascites, and a high platelet count (48 Â 10 4 mm À3 ), so-called background liver factors, as well as multiple tumours, large tumours (43 cm), high alpha-fetoprotein (4400 ng ml À1 ), and the presence of portal vein thrombus, so-called tumour factors, were factors of poor prognosis. While transcatheter arterial chemoembolisation (TACE) was a factor of good prognosis (relative risk ¼ 0.50, 95%CI ¼ 0.27 -0.89, P ¼ 0.019), local ablation therapy and transcatheter arterial chemoinfusion (TAI) were not significant prognostic factors. The survival of patients who received TACE was superior to matched patients without active treatment (P ¼ 0.009); however, we did not observe survival benefit after local ablation therapy or TAI. These results suggested that tumour factors as well as background liver factors are prognostic factors of HCC even in patients with Child C cirrhosis, and selective use of TACE in these patients provides survival benefit.

show abstract

“…Tumor vascularity was estimated by imaging ®ndings such as angiography; vascularity apparent from the imaging ®ndings has been shown to correlate with immunohistochemical evaluation using endothelial cell markers . Staining of the tumor by angiography is considered to indicate hypervascularity [Takashima and Matsui, 1980;Okuda 1986;Sumida et al, 1986;Takayasu et al, 1986;Honda et al, 1993], one of the main characteristics of HCC.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and course of small hepatocellular carcinomas in patients with hepatitis C virus types 1 and 2

et al. 2001

View full text Add to dashboard Cite

The associations between types of HCV and tumor characteristics and recurrence and survival after treatment of small HCC were investigated. Viral genotype-specific antibodies were measured in sera obtained at the time of diagnosis of HCC, in 92 patients with HCC < or = 2 cm in diameter who were treated between 1990 and 1998. The degrees of tumor differentiation and angiographically-evaluated hypervascularity were compared between patients infected with HCV type 1 and those with type 2. Survival, time to recurrence, and patterns of recurrence after initial treatment also were compared. On pathologic evaluation, 6 of 21 HCC (28.6%) in patients with HCV type 2 were well-differentiated, whereas 28 of 48 HCC (58.3%) in patients with HCV type 1 were well-differentiated (P = 0.0229). HCC in patients with HCV type 2 showed hypervascularity more frequently than HCC in patients with HCV type 1, with tumor staining evident by digital subtraction arteriography in 17 of 22 patients with HCV type 2 (77.3%) vs. 20 of 50 in patients with HCV type 1 (40.0%, P = 0.0036). Survival and overall recurrence rates were similar in patients infected with HCV type 1 and with HCV type 2 (P = 0.5537). In the analyses of patterns of recurrence, recurrences in patients infected with HCV type 2 were relatively more likely to be intrahepatic metastases (P = 0.0342), that was closely related to the differentiation of HCC. Multicentric occurrence of HCC was a more frequent type of recurrence in patients with HCV type 1 (P = 0.1619), and infection of HCV type 1 was an independent factor for multicentric occurrence in multivariate analysis (P = 0.0021). In HCC < or = 2 cm in diameter, HCV type 2 is associated with more progression of HCC than HCV type 1, whereas patients with HCV type 1 may be at higher risk for multicentric HCC occurrence after the treatment of HCC.

show abstract

Hepatocellular carcinoma: correlation of CT, angiographic, and histopathologic findings.

Cited by 59 publications

References 0 publications

Clinical Characteristics of Non-B Non-C Hepatocellular Carcinoma: A Single-Center Retrospective Study

Clinical Characteristics of Non-B Non-C Hepatocellular Carcinoma: A Single-Center Retrospective Study

Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis

Characteristics and course of small hepatocellular carcinomas in patients with hepatitis C virus types 1 and 2

Contact Info

Product

Resources

About