Hepatocellular Carcinoma: Combined Transarterial Chemoembolization and Ablation

Herren, Josi; DiSomma, Nerina M.; Ray, Charles E.

doi:10.1055/s-0039-1694066

Cited by 1 publication

(1 citation statement)

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“… 64 Lesions measuring between 3 and 5 cm may be managed with artery-targeted therapies to prolong life or, where the tumor’s position is accessible for ablation, using a mix of artery-targeted therapy and ablation. 65 The following considerations may be helpful for ablation; lesions greater than 5 cm can be treated hepatic arterially directed therapies, systemic therapies, or with radiotherapy if they are unresectable/inoperable. The benefit of adjuvant sorafenib use after successful ablation has not been clearly shown.…”

Section: Locoregional Therapymentioning

confidence: 99%

A Post-International Gastrointestinal Cancers’ Conference (IGICC) Position Statements

Yalcin,

Lacin,

Kaseb

et al. 2024

JHC

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Hepatocellular carcinoma (HCC), the most prevalent liver tumor, is usually linked with chronic liver diseases, particularly cirrhosis. As per the 2020 statistics, this cancer ranks 6th in the list of most common cancers worldwide and is the third primary source of cancer-related deaths. Asia holds the record for the highest occurrence of HCC. HCC is found three times more frequently in men than in women. The primary risk factors for HCC include chronic viral infections, excessive alcohol intake, steatotic liver disease conditions, as well as genetic and family predispositions. Roughly 40-50% of patients are identified in the late stages of the disease. Recently, there have been significant advancements in the treatment methods for advanced HCC. The selection of treatment for HCC hinges on the stage of the disease and the patient's medical status. Factors such as pre-existing liver conditions, etiology, portal hypertension, and portal vein thrombosis need critical evaluation, monitoring, and appropriate treatment. Depending on the patient and the characteristics of the disease, liver resection, ablation, or transplantation may be deemed potentially curative. For inoperable lesions, arterially directed therapy might be an option, or systemic treatment might be deemed more suitable. In specific cases, the recommendation might extend to external beam radiation therapy. For all individuals, a comprehensive, multidisciplinary approach should be adopted when considering HCC treatment options. The main treatment strategies for advanced HCC patients are typically combination treatments such as immunotherapy and anti-VEGFR inhibitor, or a combination of immunotherapy and immunotherapy where appropriate, as a first-line treatment. Furthermore, some TKIs and immune checkpoint inhibitors may be used as single agents in cases where patients are not fit for the combination therapies. As second-line treatments, some treatment agents have been reported and can be considered.

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Section: Locoregional Therapymentioning

confidence: 99%