Hepatocellular carcinoma arising from hepatic adenoma in a young woman

Yacoub, Haythem; Kchir, H.; Cherif, Dhouha; Hassine, Hajer; Haouet, Slim; Ayari, A.; Mizouni, Habiba; Mannai, Saber; Khalfallah, Mohamed Tahar; Màamouri, N.

doi:10.1002/ccr3.2975

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…Surgical resection is the preferred treatment for HCA, so there are only a few reports of the transformation of HCA into HCC. 4 , 9 , 10 Compared to female patients taking oral contraceptives, male patients, who have no history of taking hormones, are unlikely to be diagnosed with HCA transformation to HCC. There was one case report of the transformation of HCA into HCC in a male patient without risk factors in Korea, 9 where the reported risk factors for malignant transformation of hepatic adenoma were tumor size greater than 5 cm, multiple HCA, presence of β -catenin mutation, and male sex.…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathophysiology of the transformation of HCA to hepatocellular carcinoma (HCC) is not fully known, the rate of transformation of HCA to HCC has been reported to be 0.4–6.2%. 4 – 6 In previous studies, the risk factors for malignant transformation were tumor size greater than 5 cm, multiple HCA, presence of β -catenin mutation, and male sex. 6 , 7 In Korea, there have been only two cases of HCC arising from HCA in a male patient so far.…”

Section: Introductionmentioning

confidence: 98%

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Hepatocellular Carcinoma Arising from Hepatocellular Adenoma in an Elderly Male Patient

et al. 2021

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Hepatocellular adenoma is a benign tumor of the liver occurring predominantly in young women taking oral contraceptives. The malignant transformation of hepatocellular adenoma into hepatocellular carcinoma has rarely been reported. Herein, we report the case of an elderly male patient with hepatocellular carcinoma that developed from hepatocellular adenoma. The patient’s high risk for surgery and conflicting biopsy and imaging results made it difficult to determine the treatment direction. Eventually, the mass was completely removed by laparoscopic left hemi-hepatectomy without complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Hepatocellular Carcinoma Arising from Hepatocellular Adenoma in an Elderly Male Patient

et al. 2021

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“…Hepatocellular adenoma (HCA) is a rare solid, solitary, benign liver lesion that develops in an otherwise normalappearing liver [1][2][3][4]. Often, they are found in young women in association with use of estrogen-containing medications.…”

Section: Introductionmentioning

confidence: 99%

“…Often, they are found in young women in association with use of estrogen-containing medications. The annual incidence of HCA in users of oral contraceptives is approximately 30-40 cases per million in comparison with one case per million for non-users [2,3].…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma

Campos

Silva

Rodrigues

et al. 2023

Case Reports in Surgery

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Background. Hepatocellular adenoma (HCA) is an uncommon solid, solitary, benign liver lesion that develops in an otherwise normal-appearing liver. Hemorrhage and malignant transformation are the most important complications. Risk factors for malignant transformation include advanced age, male gender, use of anabolic steroids, metabolic syndrome, larger lesions, and beta-catenin activation subtype. The identification of higher risk adenomas enables the selection of patients most suitable for aggressive treatment and those who benefit with surveillance, minimizing the risks for these predominantly young patients. Case Presentation. We present the case of a 29-year-old woman with a history of oral contraceptive intake for 13 years, which was sent to evaluation in our Hepato-Bilio-Pancreatic and Splenic Unit because of a large nodular lesion in segment 5 of the liver, compatible with HCA, and was proposed to surgical resection. Histological and immunohistochemical investigation revealed an area with atypical characteristics, suggesting malignant transformation. Conclusions. HCAs share similar imaging characteristics and histopathological features with hepatocellular carcinomas; therefore, immunohistochemical and genetic studies assumes great importance to discriminate adenomas with malignant transformation. Beta-catenin, glutamine synthetase, glypican-3, and heat-shock protein 70 are promising markers to identify higher risk adenomas.

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Hepatocellular carcinoma arising from hepatic adenoma in a young woman

Cited by 2 publications

References 16 publications

Hepatocellular Carcinoma Arising from Hepatocellular Adenoma in an Elderly Male Patient

Hepatocellular Carcinoma Arising from Hepatocellular Adenoma in an Elderly Male Patient

Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma

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