Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study

Ferrand, Jonathan; Cénée, Sylvie; Laurent‐Puig, Pierre; Loriot, Marie‐Anne; Trinchet, Jean Claude; Degos, Françoise; Bronovicky, Jean-Pierre; Pelletier, G; Stücker, Isabelle

doi:10.1097/jom.0b013e31815d88e2

Cited by 7 publications

(10 citation statements)

References 42 publications

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“…Several studies ascertained occupation and industry information from a national supplemental pension fund, interviews, and questionnaires [44, 46, 50–52]. Some studies coded occupational information using classification systems such as the International Standard Classification of Occupations and the International Standard Industrial Classification of All Economic Activities [44, 46, 50].…”

Section: Resultsmentioning

confidence: 99%

“…Some studies coded occupational information using classification systems such as the International Standard Classification of Occupations and the International Standard Industrial Classification of All Economic Activities [44, 46, 50]. Job titles were typically defined as farmer, farm worker, and farm laborer, and industries as agriculture.…”

Section: Resultsmentioning

confidence: 99%

“…Job titles were typically defined as farmer, farm worker, and farm laborer, and industries as agriculture. Although farming occupation was generally not associated with liver cancer [46, 50, 52], Schiefelbein et al (2012) showed farming vs. never employed in farming was associated with a statistically significant increased risk of HCC in Egypt (adjusted OR 2.8, 95% CI 1.1, 7.2), adjusting for HBV, anti-HCV, schistosomiasis, cirrhosis, and blood transfusion (controls were matched to cases according to age and sex) (Table 2) [51]. Pesticide exposure defined based on working in the agriculture industry in Denmark was not associated with liver cancer (Table 2) [44].…”

Section: Resultsmentioning

confidence: 99%

“…Seven percent (n=5) of randomly sampled liver cancer patients were considered metastatic by pathologists, but not by the Denmark Cancer Registry [44]. Two studies did not collect or collected minimal confounder information [44, 46]. Porru et al (2001) may have over-adjusted by controlling for area of residence [50].…”

Section: Resultsmentioning

confidence: 99%

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Pesticide exposure and liver cancer: a review

VoPham

Bertrand

Hart

et al. 2017

Cancer Causes Control

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Purpose To review the epidemiologic literature examining pesticide exposure and liver cancer incidence. Methods A search of the MEDLINE and Embase databases was conducted in October 2015. Eligibility criteria included examining hepatocellular carcinoma (HCC) or primary liver cancer, pesticides as an exposure of interest, and individual-level incidence. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results Forty-eight papers were assessed for eligibility and 15 studies were included in the review. The majority of studies were conducted in China and Egypt (n=8), used a case-control design (n=14), and examined HCC (n=14). Most studies showed no association between self-reported and/or occupational exposure to pesticides and liver cancer risk. Six studies demonstrated statistically significant positive associations, including three biomarker-based studies (two using pre-diagnostic sera) that reported higher serum levels of dichlorodiphenyltrichloroethane (DDT) were associated with increased HCC risk. Studies indirectly measuring pesticide exposure using self-reported exposure, occupation, job-exposure matrices, or geographic residence demonstrated inconsistent results. These studies were limited by exposure assessment methods, lack of confounder information, minimal case confirmation, selection bias, and/or over-adjustment. Conclusions There is mixed evidence suggesting a possible association between specific pesticides and HCC risk, with the strongest evidence observed in biomarker-based studies. In particular, organochlorine pesticides, including DDT, may increase HCC risk. Future research should focus on improved pesticide exposure assessment methods, potentially incorporating multiple approaches including biomonitoring while considering the chemicals of interest, historical exposure to address latency periods, and examining specific chemicals and exposure pathways.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Pesticide exposure and liver cancer: a review

VoPham

Bertrand

Hart

et al. 2017

Cancer Causes Control

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“…Workers exposed to solvents, toluene or xylene were also associated with primary liver cancer [19,52]. Recently, a case-control study suggested a mild association between metal machining jobs and HCC among those without viral infection [53]. Nevertheless, a multicenter international liver tumor study failed to establish the association between occupational exposures and liver cancer among women, even though the viral factor was carefully considered and occupation-exposure matrix was constructed [54].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt

et al. 2010

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Background Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed.Results Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08). Conclusion Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.

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