Hepatocellular carcinoma and miRNAs: An in silico approach revealing potential therapeutic targets for polyphenols

Specific Adsorption of Magnetic Fe3O4@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

“…MicroRNA (miRNA) is a non-coding small fragment (approximately 20–22 nucleotides) single-stranded RNA molecule participating in various physiological processes in cells. , MiRNA let-7 is one of the earliest discovered miRNA families with 13 members in humans of which the miRNA let-7a is the earliest identified oncogene fragment . Numerous pathological studies have shown that the abnormal expression of miRNA let-7a in tumor cells and serum is correlated to many cancers, such as hepatocellular carcinoma (HCC), breast cancer, and pancreatic cancer, making miRNA let-7a one of crucial cancer biomarkers. At present, a variety of methods have been developed to detect miRNA let-7a, such as electrochemiluminescence, , fluorescence assays, and electrochemical methods. , Compared to the other methods, the electrochemical biosensing technology has the advantages of simpleness, low cost, and high sensitivity, which are more conducive to the establishment of practical analytical devices.…”

“…1,2 MiRNA let-7 is one of the earliest discovered miRNA families with 13 members in humans of which the miRNA let-7a is the earliest identified oncogene fragment. 3 Numerous pathological studies have shown that the abnormal expression of miRNA let-7a in tumor cells and serum is correlated to many cancers, such as hepatocellular carcinoma (HCC), 4 breast cancer, 5 and pancreatic cancer, 6 making miRNA let-7a one of crucial cancer biomarkers. At present, a variety of methods have been developed to detect miRNA let-7a, such as electrochemiluminescence, 7,8 fluorescence assays, 9 and electrochemical methods.…”