Hepatocellular Carcinoma and Hepatoid Adenocarcinoma of the Stomach

Abstract

A patient with a hepatocellular carcinoma as well as a hepatoid adenocarcinoma of the stomach is described. Although various morphologic similarities existed between the tumors, immunohistochemical studies demonstrated significant differences. Whereas carcinoembryonic antigen was expressed only by the gastric tumor, α₁-antitrypsin and α-antichymotrypsin could be demonstrated exclusively in the liver neoplasm. Histologically, clear cells were present in the the liver tumor, but were absent in the gastric counterpart. An extensive invasion of portal vein branches and of bile ducts was seen in the liver tumor only. This appears to be the first report of a concurrent hepatocellular carcinoma and hepatoid gastric cancer in the same patient.

Hepatoid adenocarcinoma of the stomach: an unusual case of elevated alpha-fetoprotein with prior treatment for hepatocellular carcinoma

“…Autopsy revealed the coexistence of primary HCC and HAC of the stomach with multiple liver metastases. Lauffer et al7 reported a case of a patient with HCC as well as HAC of the stomach without liver metastasis. To our knowledge, only two cases described above have reported concurrent HCC and HAC, and this is the first case of metachronous HCC and HAC in a patient.…”