Hepatocellular carcinoma

Akriviadis, Evangelos; Llovet, Josep M.; Efremidis, Stavros C.; Shouval, Daniel; Canelo, Rubén; Ringe, Burckhardt; Meyers, William C.

doi:10.1046/j.1365-2168.1998.00865.x

Cited by 148 publications

(111 citation statements)

References 116 publications

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“…However, there is still some controversy regarding the indications for resection of HCC. HCC with diameter of less than 5 cm is regarded by some as the best candidate for resection because of increased risk of additional nodules or vascular invasion and consequently incomplete resection with larger HCCs [245,246]. However, it has been shown that patients with a large solitary HCC are suitable for successful resection and reasonable long-term survival results can be achieved [247,248].…”

Section: Liver Resectionmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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Section: Liver Resectionmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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“…Hepatocellular carcinoma (HCC) accounts for more than 90% of all primary liver cancers and represents approximately 40% of all cancers in South-East Asia, Japan and Africa (Akriviadis et al, 1998). The majority of these HCC cases is often inoperable (Okuda et al, 1985) and the 5-year survival rate is limited to 25-50% after surgery (Colombo, 1992;Lai et al, 1995;Takenaka et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

The role of 5′ untranslated region in translational suppression of OKL38 mRNA in hepatocellular carcinoma

et al. 2006

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“…HCC usually develops from chronic inflammatory liver diseases caused by viral infection or alcohol intake that induces cirrhosis [1], [2]. Another risk factor, exposure to chemical carcinogen such as aflatoxin B1 (AFB1), is also associated with tumorigenesis of the liver [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-hetero- zygosity on chromosome 16q21-q23 and 9p21-p23

et al. 2000

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To elucidate the molecular pathology underlying the development of hepatocellular carcinoma (HCC), we used 41 highly polymorphic microsatellite markers to examine 55 HCC and corresponding non-tumor liver tissues on chromosome 9, 16 and 17. Loss-of-heterozygosity (LOH) is observed with high frequency on chromosomal region 17p13 (36/55, 65 %), 9p21-p23 (28/55, 51%), 16q21-q23 (27/55, 49 %) in tumors. Meanwhile, microsatellite instability is rarely found in these microsatellite loci. Direct sequencing was performed to detect the tentative mutation of tumor suppressor genes in these regions: p53, MTS1/p16, and CDH1/E-cadherin. Within exon 5-9 of p53 gene, 14 out of 55 HCC specimens (24 %) have somatic mutations, and nucleotide deletion of this gene is reported in HCC for the first time. Mutation in MTS1/p16 is found only in one tumor case. We do not find mutations in CDH1/E-cadherin. Furthermore, a statistically significant correlation is present between p53 gene mutation and loss of chromosome region 16q21-q23 and 9p21-p23, which indicates that synergism between p53 inactivation and deletion of 16q21-q23 and 9p21-p23 may play a role in the pathogenesis of HCC.

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Hepatocellular carcinoma

Cited by 148 publications

References 116 publications

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

The role of 5′ untranslated region in translational suppression of OKL38 mRNA in hepatocellular carcinoma

Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-hetero- zygosity on chromosome 16q21-q23 and 9p21-p23

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