Hepatocellular adenoma of the placenta: report of a case associated with maternal bicornuate uterus and fetal renal dysplasia&lt;

Dargent, Jean‐Louis; Verdebout, Jean-Marc; Barlow, Patricia; Thomas, D; Hoorens, Anne; Goossens, A.

doi:10.1046/j.1365-2559.2000.01020-5.x

Cited by 17 publications

(26 citation statements)

References 6 publications

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“…A typical lesion, which is described as a solitary and tumor-like nodule involving the placental parenchyma, is composed of fetal-type liver tissue. There are also a few reports of metastasis of smooth muscle tumors arising from sites distant from the placenta [6]. …”

Section: Discussionmentioning

confidence: 99%

Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report

et al. 2009

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IntroductionNeoplasms of the placenta are uncommon. Tumors arising from the placental tissue include two distinct histological types: the benign vascular tumor, chorangioma, and very rarely, choriocarcinoma. Benign leiomyomas, in contrast, are very common tumors of the uterine wall and occur in 0.1% to 12.5% of all pregnant women. However, the incorporation of uterine leiomyoma into the placenta is exceptional and raises the question of its origin. This case is possibly the first report on this kind of a placental tumor which has been examined using both immunohistochemistry and chromosome analysis.Case presentationA 34-year-old G4P3 Caucasian woman was followed up antenatally because of a stillbirth in her previous pregnancy. At 36 weeks' gestation, a hypoechoic, 3.6 × 4.2 cm rounded mass was noted within the placenta on ultrasound examination. Histologically, the tumor was a benign leiomyoma and this finding was supported by immunohistochemistry. The newborn infant was male. Chromosomes of the neoplasm were studied by the fluorescence in situ hybridization technique and the tumor was found to carry XX chromosomes.ConclusionA rare benign smooth muscle neoplasm involving the placental parenchyma is presented. The tumor was a uterine leiomyoma of maternal origin, which had become entrapped by the placenta. This case report is of interest to the clinical specialty of obstetrics and gynecology and will advance our knowledge of the etiology of placental tumors.

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Section: Discussionmentioning

confidence: 99%

Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report

et al. 2009

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“…It is usually described as a solitary tumor like a nodule, involving the placental parenchyma. It is usually an incidental finding without a significant pathological impact (42) .…”

Section: Other Non-trophoblastic Placental Tumorsmentioning

confidence: 99%

Can ultrasound be helpful in selecting optimal management methods for pregnancies complicated by placental non-trophpblastic tumors?

et al. 2017

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Placental chorioangioma is the most common subtype of non-trophoblastic placental tumors. Other subtypes are very rare and usually associated with an uneventful course of pregnancy. Most chorioangiomas are small and of no clinical significance. Giant chorioangiomas may be associated with serious fetal and maternal complications. So far, no established ultrasound guidelines are available for the management of placental non-trophoblastic tumors. This may be attributed to the rarity of the disease entity and its different clinical features and complications. In this article, the role of ultrasound findings such as the tumor’s size, vascularity, feeding vessels, amniotic fluid and location of the placenta in the diagnosis, treatment and follow up of these tumors is presented relying on up-todate literature review. Conservative management with serial ultrasound examinations can be an adequate method for monitoring small uncomplicated tumors. Ultrasound-guided procedures such as amnioreduction and cordocentesis can be used for amelioration of complications. Chorioangioma-specific treatment is reserved for complicated cases in the second trimester of pregnancy when prematurity is a matter of concern. Endoscopic laser ablation is indicated when the feeding vessel is superficial and small. Interstitial laser ablation is helpful when the placenta is located in the anterior uterine wall. Ligation of the feeding vessels is preferred when they are large. Alcohol injection should be performed away from the vasculature to prevent toxicity. Microcoils should be inserted as near as possible to the tumor to prevent collateral formation. Ultrasound is also a method of choice for monitoring the effectiveness of these procedures.

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“…Interestingly, a lesion morphologically similar to HCA occurs in the placenta (hepatic or hepatocellular adenoma of the placenta; Willis 1968;Chen et al 1986;Fiutowski and Pawelski 1996;Vesoulis and Agamanolis 1998;Khalifa et al 1998;Dargent et al 2000). The case of Willis (1968) may rather represent hepatic heterotopia in the placenta.…”

Section: Ectopic Liver Cell Adenomamentioning

confidence: 99%

Variants of Hepatocellular Adenoma

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Hepatocellular adenoma of the placenta: report of a case associated with maternal bicornuate uterus and fetal renal dysplasia<

Cited by 17 publications

References 6 publications

Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report

Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report

Can ultrasound be helpful in selecting optimal management methods for pregnancies complicated by placental non-trophpblastic tumors?

Variants of Hepatocellular Adenoma

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