Hepatocarcinogenesis by DDT in Rats

Harada, Takanori; Ohtsuka, Ryoichi; Takeda, Makio; Yoshida, Toshinori; Enomoto, Akiko; Kojima, Sayuri; Tomiyama, Naruto; Nakashima, Nobuaki; Ozaki, Masakazu

doi:10.1293/tox.19.155

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…While previous studies have reported that continuous intrahepatic necroinflammatory changes were observed during the process of DEN initiated carcinogenesis, the pathogenetic importance of the inflammatory response has not been well defined (Matsuda et al, 2005) DDT may induce eosinophilic altered hepatocellular foci and promote the progression of preneoplastic into hepatocellular tumors. The production of oxidative stress which might be secondary to metabolic activation could be a key factor in hepatocarcinogenesis by DDT and play an important role in tumor promotion and progression (Harada et al, 2006).…”

Section: Hepatotoxicity: Effect Of Aqueous Extract On Alanine Transammentioning

confidence: 99%

The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine

Agrawal

Sharma

Kumar

et al. 2008

Phytotherapy Research

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Histopathological studies of the hepatic tissues of Wistar rats treated with diethylnitrosamine (DEN) (200 mg/kg b wt, i.p.) once a week for 2 weeks, followed by treatment with DDT, a tumor promoter (0.05% in diet) for 2 weeks and kept under observation for another 18 weeks, demonstrated the development of malignancy. Pretreatment of Wistar rats with the aqueous extract of the roots of Asparagus racemosus prevented the incidence of hepatocarcinogenesis. Immunohistochemical staining of the hepatic tissues of rats treated with DEN showed the presence of p53+ foci (clusters of cells expressing the mutated p53 protein), whereas an absence of p53+ foci was observed in Wistar rats pretreated with the aqueous extract of the roots of Asparagus racemosus. The microsections of the hepatic tissue of rats treated with DEN followed by treatment with the aqueous extract of Asparagus racemosus showed an absence of p53+ foci. The results of the biochemical determinations also show that pretreatment of Wistar rats with the aqueous extract of Asparagus racemosus leads to the amelioration of oxidative stress and hepatotoxicity brought about by treatment with DEN. These results prove that the aqueous extract of the roots of Asparagus racemosus has the potential to act as an effective formulation to prevent hepatocarcinogenesis induced by treatment with DEN.

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Section: Hepatotoxicity: Effect Of Aqueous Extract On Alanine Transammentioning

confidence: 99%

The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine

Agrawal

Sharma

Kumar

et al. 2008

Phytotherapy Research

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“…Here, 11 pesticides were detected [11], including the pesticide DDT (dichlorodiphenyltrichloroethane), its derivatives DDD (dichlorodiphenyldichloroethane) and DDE (diclhorodiphenyldichloroethylene)-pesticides that have been permanently banned since 2009 [14]. According to Faroon et al (2019) [15], DDT and its metabolites are responsible for several harmful effects, which include hepatotoxic and hepatocarcinogenesis [16,17], neurological and neurodevelopment effects [18,19], reproductive and development effects [20,21], obesogenic effect [22][23][24][25], and suppression/stimulation of different immune responses [26,27].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Consequences of the Water We Drink: A Study Based on Field Evidence and Animal Model Experimentation

Wolfart

Theodoro

Silva

et al. 2023

Toxics

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The effect of the chronic consumption of water contaminated with residual concentrations of DDT’s metabolites (DDD—dichlorodiphenyldichloroethane and DDE—dichlorodiphenyldichloroethylene) found in the environment were evaluated on the biometric, hematological and antioxidant system parameters of the hepatic, muscular, renal and nervous tissues of Wistar rats. The results showed that the studied concentrations (0.002 mg.L−1 of DDD plus 0.005 mg.L−1 of DDE) could not cause significant changes in the hematological parameters. However, the tissues showed significant alteration in the activity of the antioxidant system represented by the increase in the activity of the enzymes gluthathione S-transferases in the liver, superoxide dismutase in the kidney, gluthathione peroxidase in the brain, and several changes in enzymatic activity in muscle (SOD, GPx and LPO). The enzymes alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) were also evaluated for the amino acids’ metabolism in the liver, with ALT showing a significant increase in the exposed animals. In the integrative analysis of biomarkers (Permanova and PCOA), the studied concentrations showed possible metabolic changes and damage to cellular structures evidenced by increased oxidative stress and body weight gain among the treated animals. This study highlights the need for further studies on the impact of banned pesticides still present in soils that may induce adverse effects in organisms that may prevail in future generations and the environment.

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DDT and Other Chlorinated Insecticides

Smith

2012

Mammalian Toxicology of Insecticides

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The use of organochlorine insecticides such as DDT, lindane and cyclodieneshas declined markedly worldwide over the last decades. Most are now banned or not used. At an acute toxicity level they have been relatively safe in use for humans. However, the greatest concerns are their persistence in people, wildlife and the environment due to their slow metabolism. Although their carcinogenicity for humans has not been supported by strong epidemiological evidence, their potential to be modulators of endocrine and immune function at levels remaining in the environment or associated with residual spraying of DDT continue to be of concern. At present, DDT is still allowed by the United Nations for combating malaria, with continual monitoring and assessment where possible. The toxicological consequences of exposure of animals and people to DDT is discussed as well as some analogues and other insecticides such as lindane, dieldrin and chlordecone that, although little used, continue to persist in surroundings and people. Because of circumstances of world health brought about by climate change or human activities that have yet to develop, there may come a time when the importance of some may re-emerge.

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Hepatocarcinogenesis by DDT in Rats

Cited by 3 publications

References 28 publications

The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine

The effect of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by diethylnitrosamine

Metabolic Consequences of the Water We Drink: A Study Based on Field Evidence and Animal Model Experimentation

DDT and Other Chlorinated Insecticides

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