Hepatoblastoma of the adult with pericardial metastasis: A case report

Celotti, Andrea; Baiocchi, Gian Luca; Ceresoli, Marco; Bartoli, Michele; Ulinici, Silvia; Portolani, Nazario

doi:10.1016/j.ijscr.2016.01.010

Cited by 9 publications

(14 citation statements)

References 13 publications

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“…A total of 43 articles met inclusion criteria including 47 cases of adult hepatoblastoma patients were collected (Table S1) . Before Carter initially reported an adult hepatoblastoma in an English literature, reported cases of hepatic embryonic mixed tumour, mixed tumour and embryonic tumour were supposed to be hepatoblastoma .…”

Section: Resultsmentioning

confidence: 99%

Adult hepatoblastoma: a review of 47 cases

Duan

Zhao

2016

ANZ Journal of Surgery

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Section: Resultsmentioning

confidence: 99%

Adult hepatoblastoma: a review of 47 cases

Duan

Zhao

2016

ANZ Journal of Surgery

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“…Huang et al [ 14 ] reported a case of metastatic hepatoblastoma in the right ventricle in an 18-year-old boy. The patient in the study by Celotti et al [ 3 ] was a 68 year-old male who had hepatoblastoma with metastasis to the pericardium. No metastasis was detected in the current patient.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] Hepatoblastoma in adults is extremely rare, with no more than 70 cases reported by 2016. [ 3 ] Whether this tumor actually develops among adults remains controversial. [ 4 ] Some experts believe that the tumor reported as hepatoblastoma may be a misdiagnosis of hepatocellular carcinoma or sarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoblastoma with pure fetal epithelial differentiation in a 10-year-old boy

2018

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Rationale:Hepatoblastoma is a rare malignant embryonal tumor that only accounts for approximately 1% of all pediatric cancers and mostly develops in children younger than 5 years old. Moreover, the occurrence of hepatoblastoma in adults is extremely rare.Patient concerns:Herein, we present a rare case of hepatoblastoma with pure epithelial differentiation in a 10-year-old boy.Pathological examination was performed. The tumor was 15 cm × 15 cm in size with clear margins. The cut surface was multiple nodular and grey-yellow. Histologically, the small cuboidal tumor cells were arranged in trabeculae with 2–3 cell layers. The tumor cells had eosinophilic or clear cytoplasm, formed dark and light areas, and were positive for alpha-fetoprotein, CK, CK8/18, CD10, hepatocyte, and GPC3. CD34 staining revealed that the sinusoids were lined by endothelial cells in the tumor tissues. The Ki67 index was approximately 20%.Diagnoses:Based on these findings, the case was diagnosed as hepatoblastoma with pure fetal epithelial differentiation.Interventions:The tumor was completely removed.Outcomes:No recurrence was found 3 months after the operation.Lessons:Hepatoblastoma with pure epithelial differentiation can also occur in older children. Children rarely notice and report any physical abnormality, and this may be among the primary reasons for the late diagnosis of the tumor. Annual heath checks may be beneficial in the detection of these rare tumors and improvement of patient outcomes.

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“…3 In adults, it is related to a poor prognosis with a median survival of < 5 months. 4 Although surgery offers the only chance for a cure, it often recurs even after complete resection. Rougemont et al described a total of 45 cases of adult hepatoblastoma, all with dismal prognosis due to late presentation and with no consensus on the treatment due to the rarity of the disease.…”

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Hepatoblastoma in an 18- Year Old Female; Rare Entity

2020

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Hepatoblastoma is a rare malignant hepatic tumor in adults. It is associated with poor prognosis as it is usually diagnosed late when the tumor is completely unresectable. Presented here, is a case of an 18-year old female with pain abdomen, vomiting, and mass over the right hypochondriac region for one month. CT scan revealed soft tissue density mass on the right lobe of liver suggestive of focal nodular hyperplasia with differential diagnosis of atypical hemangioma. Liver angiography also suggested a vascular tumor of giant hemangioma with inferior exophytic extension. The patient underwent a right extended hepatectomy. Histopathological examination revealed hepatoblastoma with predominant fetal pattern and small focal areas of embryonal pattern. The patient had an uneventful postoperative recovery and is currently undergoing chemotherapy. We present this case for its rarity and ability to masquerade other primary liver tumors in the adult age as seen in our patient.

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Hepatoblastoma of the adult with pericardial metastasis: A case report

Abstract: HighlightsHepatoblastoma in the adult is a very rare tumor with a bad prognosis.The diagnosis is always post surgery or post mortem (biopsy is not recomended).Surgery is the only curative treatment.Skills in vascular and thoracic surgery are useful for the treatment of this tumor.

Cited by 9 publications

References 13 publications

Adult hepatoblastoma: a review of 47 cases

Adult hepatoblastoma: a review of 47 cases

Hepatoblastoma with pure fetal epithelial differentiation in a 10-year-old boy

Hepatoblastoma in an 18- Year Old Female; Rare Entity

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