Hepatoblastoma in the neonatal period: An unusual presentation

Chattopadhyay, S.; Mukherjee, Shravanti; Boler, Anup Kumar; Sharma, Abhishek; Biswas, Surajit Kumar

doi:10.4103/0970-9371.103945

Cited by 13 publications

(8 citation statements)

References 12 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cHBL is an extremely rare cancer. From 1966 to 2021, approximately 51 cases have been described in the literature [3,[7][8][9][10][11][12][13][14]. This congenital form has some specific features that distinguish it from the form diagnosed beyond the neonatal period.…”

Section: Discussionmentioning

confidence: 99%

Liver Resection Using Saline-Linked Radiofrequency Technology in an Infant with Congenital Hepatoblastoma

Torino

Ilari²,

Bindi³

et al. 2022

Children

View full text Add to dashboard Cite

We herein report a case of giant congenital hepatoblastoma in a 3-month-old male treated with neoadjuvant chemotherapy and hepatic resection. After considerable reduction of the tumor with chemotherapy, a right bloodless hemihepatectomy using saline-linked radiofrequency technology (SLRT) and without clamping of the hepatic pedicle was performed. Intraoperative blood loss was minimal, and consequently, no blood transfusions were required. The surgery lasted 140 min, and SLRT was used for a total of 60 min. No complications were observed during or after the surgery. In conclusion, congenital hepatoblastoma is a very rare cancer for which surgery is an essential therapeutic step, and in our presented case, we showed that SLRT allowed for a safe and effective bloodless liver resection.

show abstract

Section: Discussionmentioning

confidence: 99%

Liver Resection Using Saline-Linked Radiofrequency Technology in an Infant with Congenital Hepatoblastoma

Torino

Ilari²,

Bindi³

et al. 2022

Children

View full text Add to dashboard Cite

show abstract

“…Delivery of these infants has been reported to be complicated by tumor rupture leading to perinatal hemorrhage and subsequent hemorrhagic shock [ 34 , 36 ]. Therefore, it is recommended that these infants be delivered by cesarean section if HBL is diagnosed antenatally [ 37 ]. HB presenting later in childhood presents similarly to other hepatic tumors, with abdominal distension or a palpable abdominal mass often associated with nonspecific symptoms such as anorexia, pain, fatigue, and weight loss [ 38 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…Clinically, neonatal HB tends to present with acute onset of increased abdominal distension and a palpable abdominal mass with resultant respiratory distress and clinical decompensation within the first days to weeks of life [35][36][37]. Delivery of these infants has been reported to be complicated by tumor rupture leading to perinatal hemorrhage and subsequent hemorrhagic shock [34,36].…”

Section: Clinical Presentation and Laboratory Findingsmentioning

confidence: 99%

“…AFP is commonly used as a tumor marker for screening and diagnosis of HB, as it is elevated in approximately 90% of patients; however, this screening marker is neither sensitive nor specific for HB and is commonly elevated in other malignant liver tumors. In small cell type HB, AFP may not rise due to decreased differentiation of cells, but in more advanced and differentiated types of HB such as fetal HB, AFP is usually elevated [35,37]. Patients can also present with marked thrombocytosis, thought to be secondary to thrombopoietin production in tumor tissues [41,42].…”

Section: Clinical Presentation and Laboratory Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

2021

View full text Add to dashboard Cite

The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups.

show abstract

“…HPC, and early HCPs. [71][72][73][74][75][76] The presence of tubular structure indicates that these cases may closely resemble the combined HCC-ICC. 70 In some patients, undifferentiated small cell component with a molecular profile similar to that of LSC can appear, suggesting that these cases may originate from the less committed stem cells prior to hepatoblasts/HPCs, which will be further discussed in the following small cell undifferentiated HBs section.…”

Section: Dovepressmentioning

confidence: 99%

Re-Recognizing the Cellular Origin of the Primary Epithelial Tumors of the Liver

Ji-liang¹,

Zhu²,

Yin³

et al. 2021

JHC

View full text Add to dashboard Cite

The primary epithelial tumors of the liver (PETL) are composed of a series of heterogeneous tumors. Although the classification of PETLs has been updated several times by the World Health Organization, the cellular origins of some tumors in this family remain to be precisely depicted. In addition, certain tumors in different categories have similar histology, molecular phenotypes and biological characteristics, suggesting that they may have the same cellular origin. In this work, a narrative review method was adopted to review the relevant papers. By comparing the expression profiles of biomarkers of liver epithelium at different lineages and stages of differentiation, the cells-of-origin of some major members of the PETL family were reassessed. We propose that 1) hepatic adenomas, hepatocellular carcinomas (HCCs) and pure fetal hepatoblastomas (HBs) share the same spectrum in their cellular origin including the hepatocytic-committed progenitors (HCP) and their differentiated descendants. 2) Bile duct adenomas, peribiliary cysts and intrahepatic cholangiocellular carcinomas (ICCs) can share the same spectrum in their cellular origin including the cholangiocytic-committed progenitors (CCP) and their differentiated descendants. 3) The cells-of-origin of embryonal HBs include liver stem cells (LSCs), hepatoblasts, and transitional cells between them. Embryonal HB with small cell element, small cell undifferentiated HB and small cell neuroendocrine carcinoma of the liver can have the same or similar cellsof-origin from LSC. Embryonal HB lacking the small cell component of the LSC phenotype and presenting both hepatocytic and bile duct/ductule components may originate from actual hepatoblasts/hepatic progenitor cells (HPCs) as the combined HCC-ICC does. 4) Teratoid hepatoblastoma and mixed epithelial/mesenchymal HBs can be derived from the LSCs or even less committed extrahepatic pluripotent stem cell. 5) Many members of the PETLs family, including those derived from LSCs, hepatoblasts/HPCs, early HCPs and CCPs, have neuroendocrine potentiality. Except for those primary hepatic neuroendocrine tumor (PHNET) exhibit hepatocytic and/or cholangiocytic phenotypes, other PHNETs subtype may be derived from the descendants of LSC that differentiate towards the upper digestive tract, pancreas or other lineages.

show abstract

Hepatoblastoma in the neonatal period: An unusual presentation

Cited by 13 publications

References 12 publications

Liver Resection Using Saline-Linked Radiofrequency Technology in an Infant with Congenital Hepatoblastoma

Liver Resection Using Saline-Linked Radiofrequency Technology in an Infant with Congenital Hepatoblastoma

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

Re-Recognizing the Cellular Origin of the Primary Epithelial Tumors of the Liver

Contact Info

Product

Resources

About