Hepatoblastoma in an adultA case report and clinical review of literatures

Yamazaki, Masato; Ryu, Munemasa; Okazumi, Shinichi; Kondo, Fukuo; Cho, Akihiro; Okada, Tadashi; Takayama, Wataru; Kawashima, Takayuki; Furuki, Arata; Hirata, Tetsuya

doi:10.1016/j.hepres.2004.08.001

Cited by 30 publications

(33 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of tumor calcification was significantly higher than in other liver tumors in mixed type [38]. Calcification may be characteristic in all liver tumors with mesenchymal elements [4]. In the present systematic study, we only confirmed 8 cases with calcifications.…”

Section: Discussioncontrasting

confidence: 41%

“…An extensive English literature search revealed only 36 reports including 40 patients with adult hepatoblastoma dating back to 1958 [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. Before Carter [9] initially reported a patient with adult hepatoblastoma in the English literature, hepatic embryonic mixed tumor, mixed tumor and embryonic tumor had been reported as hepatoblastoma [5,6,7,8,10].…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, the serum AFP level even exceeded 1,000,000 ng/ml [27,31]. These variations may be due to a difference in biological characters as in other tumors [4]. …”

Section: Discussionmentioning

confidence: 99%

“…In the present systematic study, we only confirmed 8 cases with calcifications. Morphological characteristics of adult hepatoblastoma are cystic changes and hypervascularity [4]. Cystic changes may be consecutive to intratumoral hemorrhage or necrosis, which is a common pathological finding.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Adult Hepatoblastoma: Systemic Review of the English Literature

Wang¹,

Liu²

2012

Dig Surg

View full text Add to dashboard Cite

Aims: To review all the case reports or case series of patients with adult hepatoblastoma. Methods: A search of all case reports on adult hepatoblastoma in the English literature was performed using the PubMed database. Demographic information, clinical findings, treatment modalities and outcomes were extracted and analyzed. Results: A total of 36 English articles and 40 patients with adult hepatoblastoma were collected. All these cases were confirmed by pathological diagnosis. The median age of the 40 patients was 41.5 years, including 21 males and 19 females. Hepatitis B virus tests were positive in 6 patients, and 15 patients were positive for α-fetoprotein (AFP). Liver cirrhosis was only confirmed in 7 cases. Hepatoblastoma commonly forms a single giant mass within the liver. Twenty-three cases underwent radical liver resection, including 9 cases of comprehensive treatment. The median survival time for 27 patients with available follow-ups was 4 months; 1-year survival was 29.6%. In Cox multivariate analysis, curative liver resection was an independent prognostic factor for prolonged survival (p = 0.003). Conclusions: Curative liver resection can prolong survival. Improvements in outcome will require the development of more effective systemic therapies.

show abstract

Section: Discussioncontrasting

confidence: 41%

Section: Resultsmentioning

confidence: 99%

“…In some cases, the serum AFP level even exceeded 1,000,000 ng/ml [27,31]. These variations may be due to a difference in biological characters as in other tumors [4]. …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Adult Hepatoblastoma: Systemic Review of the English Literature

Wang¹,

Liu²

2012

Dig Surg

View full text Add to dashboard Cite

show abstract

“…The overall survival is more than 70% and further improving by the advancement of current treatments. In contrast, adult hepatoblastoma is very rare and the prognosis is extremely poor because of its aggressive tumor behavior [3][4][5]. Most cases are unresectable at diagnosis and rarely respond to nonsurgical treatment including chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Adult hepatoblastoma successfully treated with multimodal treatment

Nakamura

Sho

Kanehiro

et al. 2010

Langenbecks Arch Surg

View full text Add to dashboard Cite

show abstract

Features predicting unresectability in hepatoblastoma

D’Antiga

Vallortigara

Cillo

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND. Approximately 20% of patients who have hepatoblastoma (HB) still have unresectable disease after preoperative chemotherapy (POC). In these circumstances, orthotopic liver transplantation (OLT) should be performed 1 month after POC. The authors sought to identify presenting features that would predict unresectability in patients with HB and to provide suggestions for early referral and listing for OLT. METHODS. Notes, radiology films, and histology from patients who were treated over the previous 20 years were reviewed. Unfeasible resection was defined by bilobar involvement, vascular extension, and metastatic disease after POC. Failed conservative treatment (FCT) was used to categorize patients who were not disease‐free with their native liver ≥1 year after surgery. RESULTS. Of 28 patients who were studied, 14 patients underwent resection, and 10 patients required OLT. Four patients did not undergo any type of surgery because of tumor progression. Overall, the 5‐year survival rate was 76% (95% confidence interval, 54.8–89%). Predictors of FCT were multifocality (P = .006), a high pretreatment extent of tumor (PRETEXT) score (III or IV; P = .006), portal vein involvement (P = .02), hepatic vein involvement (P = .02), or vena cava involvement (P = .05). Patients who achieved a curative resection presented at a younger age (median, 0.7 years vs 4.2 years, P = .02). Patients who had multifocal lesions and those who had an α‐fetoprotein (αFP) level <100 ng/mL survived only if they underwent transplantation. CONCLUSIONS. Patients with HB who were managed by combined chemotherapy and surgery has a high survival rate. Older patients who had multifocal tumors, high PRETEXT scores, involvement of major liver vessels, and αFP levels <100 ng/mL were less likely to achieve curative resection. These findings at presentation should lead the clinicians to liaise early with a transplantation center. Cancer 2007. © 2007 American Cancer Society.

show abstract

Hepatoblastoma in an adultA case report and clinical review of literatures

Cited by 30 publications

References 17 publications

Adult Hepatoblastoma: Systemic Review of the English Literature

Adult Hepatoblastoma: Systemic Review of the English Literature

Adult hepatoblastoma successfully treated with multimodal treatment

Features predicting unresectability in hepatoblastoma

Contact Info

Product

Resources

About