Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation

Meyers, Arthur B.; Towbin, Alexander J.; Geller, James I.; Podberesky, Daniel J.

doi:10.1007/s00247-012-2366-6

Cited by 50 publications

(31 citation statements)

References 20 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is best seen in the late portal venous phase . If hepatocyte‐specific contrast agents are used, the mass appears hypointense in comparison with the background liver …”

Section: Discussionmentioning

confidence: 99%

Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma

et al. 2013

View full text Add to dashboard Cite

The outcomes of hepatic undifferentiated embryonal sarcoma (HUES) have historically been limited by persistent, unresectable disease and the subsequent development of disease resistance and dissemination. We present our institutional experience with HUES and assess current treatment trends and outcomes in the era of liver transplantation. We conducted a retrospective chart review of cases presenting with HUES at our institution over the past 10 years. The collected data included age, sex, presenting symptoms, imaging and the associated Pretreatment Extent of Disease (PRETEXT) score, pathology, chemotherapy, surgical interventions, and outcomes. Approval was obtained from the institutional review board of the Cincinnati Children's Hospital Medical Center. HUES was identified in 6 patients (4 males and 2 females) with a median age at diagnosis of 11 years (range 5 7-13 years). Initial imaging was available for all but 1 patient. The PRETEXT stage for these patients ranged from II to III. One patient was diagnosed with lung metastases. Two patients underwent upfront resection, and 1 patient received neoadjuvant therapy and then conventional resection. Three patients were treated with orthotopic liver transplantation (OLT) after neoadjuvant chemotherapy (primary OLT in 2 cases and salvage OLT for local recurrence in 1 case). Two patients received posttransplant adjuvant chemotherapy. All 6 patients remained in clinical remission with a mean follow-up of 35 months (range 5 12-84 months). In conclusion, OLT has rarely been reported as a treatment option for HUES. The addition of liver transplantation as a surgical option for treating patients with HUES can result in improved survival for patients whose tumors are initially unresectable or recur.

show abstract

“…This is best seen in the late portal venous phase . If hepatocyte‐specific contrast agents are used, the mass appears hypointense in comparison with the background liver …”

Section: Discussionmentioning

confidence: 99%

Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Either three-phase computed tomography scanning (noncontrast, arterial, and venous) or MRI with contrast agents are recommended modalities. MRI with EOVIST, a new gadolinium-based agent that is preferentially taken up and excreted by hepatocytes, is being used with increased frequency and may improve detection of multifocal disease [2].…”

Section: Pretreatment Extent Of Disease: Pretext and Post-textmentioning

confidence: 99%

Hepatoblastoma state of the art

Meyers

Tiao

Goyet

et al. 2014

Current Opinion in Pediatrics

154

View full text Add to dashboard Cite

show abstract

“…The NTDB is maintained by the American College of Surgeons, Committee on Trauma (ACS COT) [11]. Criteria for analysis included adolescents, age 15–19, with a length of stay (LOS) greater than 1 day, treated at an ACS COT verified Level 1 ATC or PTC.…”

Section: Methodsmentioning

confidence: 99%

Pediatric and adult trauma centers differ in evaluation, treatment, and outcomes for severely injured adolescents

Walther

Falcone

Pritts

et al. 2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Background/purpose This study aims to investigate differences in imaging, procedure utilization, and clinical outcomes of severely injured adolescents treated at adult versus pediatric trauma centers. Methods The National Trauma Data Bank was queried retrospectively for adolescents, 15–19 years old, with a length of stay (LOS) > 1 day and Injury Severity Score (ISS) >25 treated at adult (ATC) or pediatric (PTC) Level 1 trauma centers from 2007 to 2011. Patient demographics and utilization of imaging and procedures were analyzed. Univariate and multivariate regression analysis was used to compare outcomes. Results Of 12,861 adolescents, 51% were treated at ATC. Older age and more nonwhites were seen at ATC (p < 0.01). Imaging and invasive procedures were more common at ATC (p < 0.01). Shorter LOS (p = 0.03) and higher home discharge rates (p < 0.01) were seen at PTC. ISS and mortality did not differ. Age, race, ATC care (all p < 0.01), and admission systolic blood pressure (SBP) (p = 0.03) were predictors of CT utilization. ISS, SBP, and race (p < 0.01) were risk factors for overall mortality; SBP (p = 0.03) and ISS (p < 0.01) predicted death from penetrating injury. Conclusions Severely injured adolescents experience improved outcomes and decreased imaging and invasive procedures without additional mortality risk when treated at PTC. PTC is an appropriate destination for severely injured adolescents.

show abstract

Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation

Cited by 50 publications

References 20 publications

Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma

Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma

Hepatoblastoma state of the art

Pediatric and adult trauma centers differ in evaluation, treatment, and outcomes for severely injured adolescents

Contact Info

Product

Resources

About