Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system—What is normal?

Ringe, Kristina; Husarik, Daniela B.; Gupta, Rajan T.; Boll, Daniel T.; Merkle, Elmar M.

doi:10.1016/j.ejrad.2010.03.008

Cited by 44 publications

(34 citation statements)

References 13 publications

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“…Thanks to this property, gadoxetate-enhanced MRI can provide T 1 weighted MR cholangiography images (Figure 5a). 36 Recently, Ringe et al 37 evaluated the hepatobiliary transit time of gadoxetate, revealing that this contrast agent could be detected in the intrahepatic bile ducts and the common bile duct in all patients (100%), and in the gallbladder in 86.9% of patients on 20-min hepatobiliary phase images. The mean transit times for contrast appearance in that study were 12 min 13 s for intrahepatic bile ducts, 12 min 27 s for the common bile duct and 13 min 32 s for the gallbladder in normal patients.…”

Section: Clinical Applications Of Gadoxetate-enhanced Mri Evaluation mentioning

confidence: 99%

Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism

Choi¹,

Huh²,

Woo³

et al. 2016

BJR

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Gadolinium ethoxybenzyl dimeglumine (gadoxetate) is a recently developed hepatocyte-specific MRI contrast medium. Gadoxetate demonstrates unique pharmacokinetic and pharmacodynamic properties, because its uptake in hepatocytes occurs via the organic anion transporting polypeptide (OATP) transporter expressed at the sinusoidal membrane, and its biliary excretion via the multidrug resistance-associated proteins (MRPs) at the canalicular membrane. Based on these characteristics, gadoxetate-enhanced MRI can provide functional information on hepatobiliary diseases, including liver function estimation, biliary drainage evaluation and characterization of hepatocarcinogenesis. In addition, understanding its mode of action can provide an opportunity to use gadoxetate for cellular and molecular imaging. Radiologists and imaging scientists should be familiar with the basic mechanism of gadoxetate and OATP/MRP transporters.

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Section: Clinical Applications Of Gadoxetate-enhanced Mri Evaluation mentioning

confidence: 99%

Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism

Choi¹,

Huh²,

Woo³

et al. 2016

BJR

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“…40,41 Kim and colleagues, however, reported that post-contrast MRCP is acceptable if obtained within a few minutes of gadoxetic acid injection 42 because excretion of the contrast agent into the bile duct does not start until approximately 5 to 10 min after injection. 43 DiŠusion-weighted images can also be obtained after gadoxetic acid administration. The presence of gadoxetic acid in the liver parenchyma does not aŠect tumor conspicuity or measurement of the apparent diŠusion coe‹cient (ADC) of tumors on diŠusion-weighted images.…”

Section: Rules For the Hepatocyte Phase Delay Before Hepatocyte Phasementioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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Since its launch onto the world medical market, gadoxetic acid has received a great deal of attention from a diverse group of researchers, including gastroenterologists, hepatologists, and abdominal radiologists. Gadoxetic acid in liver magnetic resonance (MR) imaging might be considered to have excellent utility. However, several issues remain that radiologists should keep in mind when utilizing this product. We compiled this review to introduce gadoxetic acid, describe how it should be used, highlight the situations in which it is most and least reliable, and suggest potential avenues for future research.

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“…For normal subjects with normal hepatic function and no bile duct obstruction, the intrahepatic and extrahepatic bile ducts enhance intensely at 20 min after the administration of Gd-EOB-DTPA [20] (fig. 1).…”

Section: Hepatic Function From Biliary Gd-eob-dtpa Enhancementmentioning

confidence: 99%

“…For instance, regional variations in hepatic parenchymal tissue composition and nodularity can be readily depicted on hepatic magnetic resonance (MR) images [12,13]. In addition, studies have reported the appropriate characterization of hepatic parenchymal properties using functional MR techniques including MR spectroscopy [14,15], MR elastography [16], diffusion-weighted imaging [17], MR relaxometry [18], and Gd-EOB-DTPA-enhanced MRI [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43]. In this article, we will review and discuss recently published studies that used Gd-EOB-DTPA-enhanced hepatic MRI to evaluate hepatic function.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

Bae

Kim²,

Lee³

et al. 2012

Dig Dis

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Assessment of hepatic function is essential in determining the prognosis and clinical management of a patient who has chronic liver disease or undergoes liver surgery. For a patient with locally varying hepatic parenchymal abnormalities, a regional assessment of hepatic function mapped onto hepatic anatomy is clinically more meaningful than conventional global metrics of hepatic function. Of late, hepatic magnetic resonance imaging has been increasingly used because of its superb tissue contrast and delineation of hepatic morphology and underlying abnormalities. The introduction of hepatocyte-specific contrast agents such as Gd-EOB-DTPA allows us to view not only the hepatic anatomy but also assess regional hepatic function. In this article, we review and discuss recently published studies that used Gd-EOB-DTPA-enhanced magnetic resonance imaging to evaluate hepatic function.

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Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system—What is normal?

Cited by 44 publications

References 13 publications

Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism

Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

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