Hepatobiliary Scintigraphy With SPECT in Infancy

Abstract

The addition of SPECT 4 to 6 hours postinjection of tracer significantly improves the diagnostic accuracy of hepatobiliary scintigraphy compared with planar imaging alone. This accuracy is as good as HBS performed after phenobarbitone stimulation. The combined technique of HBS with SPECT and phenobarbitone has the highest accuracy. Delayed imaging at 24 hours is usually not necessary.

Endoscopic retrograde cholangiopancreaticography prior to explorative laparotomy avoids unnecessary surgery in patients suspected for biliary atresia

“…First data from a retrospective SPECT study with 20 BA patients are promising but need to be confirmed by further trials [16].…”

“…With the intention of finding a non-invasive test that differentiates exactly between hepatocellular and obstructive jaundice, several diagnostic tools have been investigated. Representative studies that refer to sensitivity and specificity of particular examinations are listed in Table 1 [14][15][16][17][18][19][20][21][22][23]. However, all studies contained only small numbers of BA patients (4-48 patients), and the sensitivity and specificity varied widely.…”

Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia

“…In addition, it has been reported that hepatobiliary planar imaging with 99mTc-EHIDA plus tomography or 1-h hepatobiliary scintigraphy provides more radioactive imaging of the gall bladder or intestine than 24-h delay imaging (Shao et al, 2008;Yang et al, 2009;Xu et al, 2009). In the study by Sevilla et al (2007), the diagnostic efficacy for BA was compared among plane imaging 4-6 h after imaging agent injection, planar imaging 4-6 h after imaging agent injection plus tomography, and tomography 4-6 h after phenobarbital injection, and the sensitivities of the 3 techniques were found to be identical. Moreover, the necessity and significance of 6-h hepatobiliary scintigraphy with 99mTc-EHIDA was emphasized when the specificity of plane imaging 4-6 h after imaging agent injection plus tomography was shown to be equivalent to, or even better than, the specificity reported for phenobarbital interventional in the literature.…”

Hepatobiliary and pancreatic imaging in children—techniques and an overview of non-neoplastic disease entities

“…Premedication with oral phenobarbital for at least 5 d prior to the imaging improves the diagnostic accuracy. The combined technique of HBS with SPECT and phenobarbital has the highest accuracy (up to 98%) [19, 20]. It usually permits accurate differentiation of biliary atresia from other causes of neonatal jaundice.…”