Hepatobiliary scintigraphy and its clinical implications: mini review

Afzal, Muniba; Ali, Syed Muhammad; Khairy, Ahmed Talaat; Khattabi, Mazin; Shahid, Fakhar; Ramzee, Ahmed Faidh; Ahmed, Khalid

doi:10.18203/2349-2902.isj20210402

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HBS is a radionuclide diagnostic imaging modality that is used to evaluate hepatocellular function and the biliary system by tracing the synthesis and flow of bile from the liver and its passage through the biliary system into the small intestine[ 7 ]. The technique assesses the function of hepatocytes, the patency and integrity of the biliary ducts, GB contractility, and sphincter of Oddi function[ 23 ]. HBS has frequently been used to investigate the physiological parameters of the GB during emptying and filling[ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Classification of hepatobiliary scintigraphy patterns in segmented gallbladder according to anatomical discordance

Lee¹,

Jung²,

Lee³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Hepatobiliary scintigraphy (HBS) is a useful diagnostic imaging technique that uses radiotracers to evaluate the function of the gallbladder (GB) and biliary system. In segmented GB, s ome HBS images reveal a discordant GB boundary as compared to anatomical images. AIM To evaluate the characteristics of HBS in segmented GB and determine the clinical relevance according to HBS characteristics. METHODS A total of 268 patients with chronic cholecystitis, gallstones, or biliary colic symptoms who underwent HBS between 2011 and 2020 were enrolled. Segmented GB was defined as segmental luminal narrowing of the GB body on computed tomography (CT) or magnetic resonance (MR) images, and HBS was examined 1 mo before or after CT or MR. Segmented GB was classified into 3 types based on the filling and emptying patterns of the proximal and distal segments according to the characteristics of HBS images, and GB ejection fraction (GBEF) was identified: Type 1 was defined as a normal filling and emptying pattern; Type 2 was defined as an emptying defect on the distal segment; and Type 3 was defined as a filling defect in the distal segment. RESULTS Segmented GB accounted for 63 cases (23.5%), including 36 patients (57.1%) with Type 1, 18 patients (28.6%) with Type 2, and 9 patients (14.3%) with Type 3 emptying pattern. Thus, approximately 43% of HBS images showed a discordant pattern as compared to anatomical imaging of segmented GB. Although there were no significant differences in clinical symptoms, rate of cholecystectomy, or pathological findings based on the type, most gallstones occurred in the distal segment. Reported GBEF was 62.50% ± 24.79% for Type 1, 75.89% ± 17.21% for Type 2, and 88.56% ± 7.20% for Type 3. Type 1 showed no difference in reported GBEF compared to the non-segmented GB group (62.50% ± 24.79% vs 67.40% ± 21.78%). In contrast, the reported GBEF was higher in Types 2 and 3 with defective emptying and filling when compared to Type 1 (80.11% ± 15.70% vs 62.57% ± 24.79%; P = 0.001). CONCLUSION In segmented GB, discordance in the filling patterns detected by HBS and anatomical imaging could lead to misinterpretation of GBEF. For this reason, clinicians should be cautious when interpreting HBS results in patients with segmented GB.

show abstract

Section: Discussionmentioning

confidence: 99%