Hepatobiliary Manifestations of Human Immunodeficiency Virus

Vachon, Marie-Louise C.; Perumalswami, Ponni V.; Dieterich, Douglas T.

doi:10.1002/9781119950509.ch41

Cited by 1 publication

(2 citation statements)

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“…5), while VBDS in this patient is induced by CMV infection, papillary stenosis is due to HIV cholangiopathy. Although, sphincterotomy has been reported to be of benefit in patients with papillary stenosis, orthotopic liver transplantation remains the only option, if the patient is a suitable candidate 12 …”

Section: Discussionmentioning

confidence: 99%

“…Although, sphincterotomy has been reported to be of benefit in patients with papillary stenosis, orthotopic liver transplantation remains the only option, if the patient is a suitable candidate. 12 In conclusion, jaundice in a patient with advanced HIV infection may be multifactorial. We present a unique case with co-occurrence of VBDS and papillary stenosis (as a component of AIDS cholangiopathy) in HIV infection, which to the best of our published work search, has not been documented earlier.…”

Section: H Epatobiliary Disease Occurs In a Minoritymentioning

confidence: 96%

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Co‐occurrence of cytomegalovirus‐induced vanishing bile duct syndrome with papillary stenosis in HIV infection

Tyagi

Puri

Sakhuja

et al. 2013

Hepatology Research

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Jaundice in patients with AIDS can be a result of diverse conditions ranging from opportunistic infections to drug-related hepatotoxicity. With the advent of antiretroviral therapy (ART), the prevalence of AIDS cholangiopathy as a cause of jaundice has decreased; on the other hand, ART-related hepatotoxicity has become one of the commonest causes of jaundice in these patients. AIDS cholangiopathy is a rare condition of extrahepatic biliary obstruction in patients with advanced HIV infection, usually due to opportunistic infections. Vanishing bile duct syndrome (VBDS) is an acquired disorder characterized by progressive destruction and loss of interlobular bile ducts causing intrahepatic cholestasis. Herein, we report co-occurrence of fatal cytomegalovirus (CMV)-induced VBDS along with papillary stenosis, as a component of AIDS cholangiopathy, which to the best of our knowledge has not been documented earlier. This is perhaps the third case of VBDS in a patient with AIDS, and the second in association with CMV infection. VBDS in AIDS has a poor outcome, and liver transplantation may be considered only in a suitable candidate.

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Section: Discussionmentioning

confidence: 99%

Section: H Epatobiliary Disease Occurs In a Minoritymentioning

confidence: 96%