Hepatobiliary Imaging in Liver-directed Treatments

Roekel, Caren van; Reinders, Margot T.M.; Velden, Sandra van der; Lam, Marnix G. E. H.; Braat, Manon N.G.J.A.

doi:10.1053/j.semnuclmed.2019.01.007

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…Objective response (CR or PR) at three months after treatment was obtained in only 6% of our patients. This is in line with other studies in salvage mCRC patients, with reported response ranges of 6%-24% (24,56,57). Median OS in our study was ten months, which is also in line with other studies in a comparable patient population (22,24,58).…”

Section: Discussionsupporting

confidence: 93%

“…Treatment may be adapted based on liver function distribution, e.g. choosing sequential lobar treatment instead of a whole-liver approach (57).…”

Section: Discussionmentioning

confidence: 99%

“…In HCC patients, a high LSF was associated with infiltrative morphologic structure, tumor burden >50%, portal vein invasion and arterioportal shunting. In other tumor types, such as colorectal carcinoma metastases, neuroendocrine tumors and cholangiocarcinomas, a larger tumor size and greater tumor burden were associated with lung shunting (57). In patients with these factors, care should be taken to avoid deposition of radioactive microspheres in the lungs.…”

Section: Lung Shunt Calculationmentioning

confidence: 99%

“…An advantage of using radioembolization is that it not only induces hypertrophy, but that it also offers tumor control, in contrast with PVE. Also, it provides a test-of-time: because of the prolonged interval between radioembolization and surgery, subclinical, previously undetected metastases may become detectable (57). Moreover, radioembolization can be used to improve the secondary resectability rate: in a substudy on patients of the SIRFLOX trial, the resectability rates after treatment with chemotherapy versus treatment with chemotherapy combined with radioembolization were assessed.…”

Section: Supplemental Tables and Figuresmentioning

confidence: 99%

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Personalized radioembolization for colorectal cancer patients with liver metastases

Roekel¹

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Chapter 1 Introduction and outline Chapter 2 Radioembolization Chapter 3 Quality of life in patients with liver tumors treated with holmium-166 radioembolization Chapter 4 Evaluation of the safety and feasibility of same day 166 Ho-radioembolization simulation and treatment of hepatic metastases Chapter 5 Mode of progression after radioembolization in patients with colorectal cancer liver metastases Chapter 6 First evidence for a dose-response relationship in patients treated with 166 Ho-radioembolization: a prospective study Chapter 7 Dose-effect relationships of holmium-166 radioembolization in colorectal cancer Chapter 8 The efficacy of coil-embolization to obtain intrahepatic redistribution in radioembolization: qualitative and quantitative analyses Chapter 9 Use of an anti-reflux catheter to improve tumor targeting for holmium-166 radioembolization -a prospective, within-patient randomized study Chapter 10 Discussion Chapter 11 Summary Chapter 12 Nederlandse samenvatting Chapter 13 Addenda Review Committee List of publications Dankwoord Biography General introduction 8 Chapter 1Although there are many treatment options for colorectal cancer patients with liver metastases, colorectal cancer still remains the second most common type of cancer death worldwide (1).There is a wide variety in colorectal cancer incidence rates: the disease can be considered a marker of socioeconomic development and is more prevalent in countries with a high human development index. In developing countries, such as Russia and China, there is an increase in both incidence and mortality.In long-term developed countries, such as the United Kingdom and Denmark, there is an increase in incidence but a decrease in mortality. In other countries, such as France and the United States, a decrease in both incidence and mortality is seen. The rises in incidence can be explained by a change in dietary patterns (processed meat and alcohol drinks) and lifestyle factors (a sedentary lifestyle), as well as a consequence of screening programs that lead to early detection. The decreases in mortality are due to improved treatment strategies in developed countries (1).The incidence rate increases with age, with the median age worldwide being 66 years. Although the incidence and mortality rates decline for almost all age groups, in high-income countries, they are increasing for individuals younger than 50 years. This is likely due to the change in diet and lifestyle over the past decades, which is first reflected in incidence rates in young age groups. In this patient group, most patients present with advanced-stage disease. For patients with distant-stage disease, the five-year survival rate is only 14% (2). The first site of metastasis is the liver and up to 30% of patients with colorectal cancer develops hepatic metastases (3). For these patients, improved treatment strategies are needed.One of these improved treatment strategies is radioembolization.Radioembolization is a treatment option for patients with primary or secondary liver tumors. The treat...

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Section: Discussionsupporting

confidence: 93%

“…Treatment may be adapted based on liver function distribution, e.g. choosing sequential lobar treatment instead of a whole-liver approach (57).…”

Section: Discussionmentioning

confidence: 99%

Section: Lung Shunt Calculationmentioning

confidence: 99%

Section: Supplemental Tables and Figuresmentioning

confidence: 99%

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Personalized radioembolization for colorectal cancer patients with liver metastases

Roekel¹

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“…Moreover, since the tumoral liver cells are hypofunctional compared to normal hepatocytes, cholescintigraphy can help in the diagnosis of more and less differentiated (benign and malignant, respectively) liver tumors. In patients with impaired liver function after a chemotherapy treatment, HIDA scan has been reported to be the best choice to assess the intrahepatic regional distribution of liver function [24].…”

Section: Cholescintigraphymentioning

confidence: 99%

Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds

et al. 2023

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Evaluation of the hepatobiliary function is critical for the clinicians, not only for the diagnosis of a large variety of liver diseases but also in the follow-up and management of some patients, for instance, those with different degrees of cholestasis suffering from a drug-induced liver injury (DILI) or scheduled for liver resection. Currently, the determination of global liver function mainly relies on laboratory tests, clinical scores, and data from images obtained with ultrasonography, computed tomography (CT), or magnetic resonance. Nuclear medicine scanning, displaying either planar or three-dimensional spatial distribution of liver function, is enhanced when using hepatotropic tracers based on classical radioisotopes such as technetium-99m (99mTc) and with higher resolution using metabolized probes such as those based on monosaccharide derivatives labeled with 18F. Other cholephilic compounds, and hence selectively secreted into bile, have been proposed to visualize the correct function of the liver parenchyma and the associated secretory machinery. This review aims to summarize the state-of-the-art regarding the techniques and chemical probes available to monitor liver and gallbladder function, in some cases based on imaging techniques reflecting the dynamic of labeled cholephilic compounds.

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3D voxel-based dosimetry to predict contralateral hypertrophy and an adequate future liver remnant after lobar radioembolization

Grisanti

Prieto

Bastidas

et al. 2021

Eur J Nucl Med Mol Imaging

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Hepatobiliary Imaging in Liver-directed Treatments

Cited by 5 publications

References 44 publications

Personalized radioembolization for colorectal cancer patients with liver metastases

Personalized radioembolization for colorectal cancer patients with liver metastases

Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds

3D voxel-based dosimetry to predict contralateral hypertrophy and an adequate future liver remnant after lobar radioembolization

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