1998
DOI: 10.1006/taap.1998.8495
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Hepatobiliary Effects of Tertiary-Butylhydroperoxide (tBOOH) in Isolated Rat Hepatocyte Couplets

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Cited by 27 publications
(15 citation statements)
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“…By its turn, t-BHP is a pro-oxidant agent widely used as an inducer of oxidative stress [26,31]. So, the effect of the compounds on t-BHP-induced oxidative stress on H9c2 cells was assessed by fluorescence microscopy, through the detection of oxidized dichlorofluorescein (DCF) form.…”
Section: Measurement Of Intracellular Reactive Oxygen Speciesmentioning
confidence: 99%
“…By its turn, t-BHP is a pro-oxidant agent widely used as an inducer of oxidative stress [26,31]. So, the effect of the compounds on t-BHP-induced oxidative stress on H9c2 cells was assessed by fluorescence microscopy, through the detection of oxidized dichlorofluorescein (DCF) form.…”
Section: Measurement Of Intracellular Reactive Oxygen Speciesmentioning
confidence: 99%
“…tert-Butyl hydroperoxide is a potent thiol oxidising agent that induces oxidative stress, with subsequent oxidation of intracellular glutathione, glutathione disulfide formation and changes to cellular membranes through lipid peroxidation [22]. It is used here as an alternative to H 2 O 2 for the induction of oxidative stress in an in vivo model.…”
Section: Discussionmentioning
confidence: 99%
“…There have been other reports of the effects of t BOOH on the liver. For example, treating cultured hepatocytes with 0.05 mM t BOOH induced lipid-signalled cell death [30] and exposure of isolated hepatocyte couplets to up to 200 mM t BOOH impaired biliary transport [22]. Higher doses, such as 0.4 mM t BOOH induced apoptosis of isolated hepatocytes [31].…”
Section: Discussionmentioning
confidence: 99%
“…The cholestatic agents, taurolithocholate [8], cyclosporin A [8,20] and β-oestradiol 17-(β-D-glucuronide) (17βEG) [8], as well as the oxidative-stress-inducers menadione [8,21] and t-butylhydroperoxide (tBOOH) [8,22], all increased tightjunctional permeability, as assessed by cVR of CLF, in a dose-dependent manner.…”
Section: Studies Of Alterations In Tight-junctional Integrity Using Hmentioning
confidence: 98%