Hepatobiliary Disorders in Celiac Disease: An Update

Abstract

This communication reviews recent literature and summarizes hepatobiliary abnormalities that may complicate the clinical course of celiac disease. A wide spectrum of hepatobiliary diseases has been described, including asymptomatic elevations of liver enzyme levels, nonspecific hepatitis, nonalcoholic fatty liver disease, and autoimmune and cholestatic liver disease. Moreover, in the majority of patients, liver enzyme levels will normalize on a gluten-free diet. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. Because many celiac patients do not have overt gastrointestinal symptoms, a high index of suspicion is required. Simple methods of detecting celiac disease such as serum antibody tests help in the early identification of the disease, thus preventing serious complications of the disorder. The IgG DGP antibody test and IgA tTG antibody test used in combination are an excellent screening test for suspected cases of celiac disease.

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

“…On the other hand, asymptomatic elevation in liver enzymes is due to increased intestinal permeability resulting in translocation of gut bacteria, kupffer cell stimulation, and production of tumor necrosis factor-α (TNF-α), pro-inflammatory cytokine, and reactive oxygen species, resulting in nonalcoholic steatohepatitis (NASH). In addition to, CD share common immunogenic factors and immunopathogenesis with other hepatobiliary disorders such as autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing Cholangitis that may contribute to asymptomatic elevation in liver enzymes (34).…”

Non alcoholic fatty liver disease in a young male with celiac disease

“…Many forms of hepatic diseases can be seen in those affected with celiac disease, including non alcoholic fatty liver disease and Nonalcoholic steatohepatitis (NASH) [2]. Non-alcoholic fatty liver disease or NAFLD is said to the commonest cause of chronic liver disease in the developed world [3, 4].…”

“…Non-alcoholic fatty liver disease or NAFLD is said to the commonest cause of chronic liver disease in the developed world [3, 4]. Celiac disease is seen in 4 to 13% in those having NASH [2]. The exact mechanism of this association is not known but it is plausible that this may be due to the increased intestinal permeability along with malabsorption of choline, a lipotropic factor and vitamin B6 [2].…”

“…Celiac disease is seen in 4 to 13% in those having NASH [2]. The exact mechanism of this association is not known but it is plausible that this may be due to the increased intestinal permeability along with malabsorption of choline, a lipotropic factor and vitamin B6 [2]. According to one study, celiac disease is more often seen amongst those NAFLD patients having a BMI less than 27 kg/m 2 [5].…”

Fatty Acid Profile Optimization in Edible Oil Blend Through Linear Programming

“…It is well recognized that the incidence of chronic disorders is escalating in India and fat consumption trends play a prominent role in obesity and related disorders, including type II diabetes, hypertension, cardiovascular diseases, nonalcoholic fatty liver disease, obstructive sleep apnea, gastroesophageal reflux disease, musculoskeletal disorders, a variety of cancers and a number of psychosocial concerns 1,2 . Functional role of fat as one of the major macro nutrient in the diet is manifold.…”