Hepatobiliary disorders and complications of inflammatory bowel disease

Venkatesh, Preethi G.K.; Navaneethan, Udayakumar; Shen, Bo

doi:10.1111/j.1751-2980.2011.00511.x

Cited by 31 publications

(16 citation statements)

References 146 publications

(177 reference statements)

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“…However, recent results have associated these manifestations to IBD activity [51] and the use of TNF- α inhibitors [52], exemplified by hepatobiliary manifestations, in terms of frequency and severity [53–55]. At the same time, these IBD complications remain underdiagnosed [56].…”

Section: Discussionmentioning

confidence: 99%

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Moura

Andrade

Araújo³

et al. 2016

Oxidative Medicine and Cellular Longevity

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Lipoic acid (LA) and N-acetylcysteine (NAC) are antioxidant and anti-inflammatory agents that have not yet been tested on mild ulcerative colitis (UC). This study aims to evaluate the action of LA and/or NAC, on oxidative stress and inflammation markers in colonic and hepatic rat tissues with mild UC, induced by dextran sodium sulfate (DSS) (2% w/v). LA and/or NAC (100 mg·kg·day−1, each) were given, once a day, in the diet, in a pretreatment phase (7 days) and during UC induction (5 days). Colitis induction was confirmed by histological and biochemical analyses (high performance liquid chromatography, spectrophotometry, and Multiplex®). A redox imbalance occurred before an immunological disruption in the colon. NAC led to a decrease in hydrogen peroxide (H2O2), malondialdehyde (MDA) levels, and myeloperoxidase activity. In the liver, DSS did not cause damage but treatments with both antioxidants were potentially harmful, with LA increasing MDA and LA + NAC increasing H2O2, tumor necrosis factor alpha, interferon gamma, and transaminases. In summary, NAC exhibited the highest colonic antioxidant and anti-inflammatory activity, while LA + NAC caused hepatic damage.

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Section: Discussionmentioning

confidence: 99%

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Moura

Andrade

Araújo³

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…IPH is an uncommon liver disease of unknown etiology that includes a group of disorders with similar clinical characteristics, encompassing a wide spectrum of histological alterations (hence the use of other terms to describe the condition, such as hepatoportal sclerosis, non-cirrhotic portal fibrosis, incomplete septal cirrhosis and nodular regenerative hyperplasia) (7,8). This fact probably reflects different stages of the disease or multiple pathological processes that converge in a syndrome with similar clinical characteristics.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease

Ferrer¹,

Herrera²,

Moya³

et al. 2015

Rev Esp Enferm Dig

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Introduction:The possibility of developing idiopathic portal hypertension has been described with thiopurine treatment despite compromises the prognosis of these patients, the fact its true prevalence is unknown.Material and methods: A cross-sectional study was conducted in a cohort of inflammatory bowel disease (IBD) patients followed at our unit, to determine the prevalence of diagnosis of idiopathic portal hypertension (IPH) and its relationship with thiopurine treatment.Results: At the time of the analysis, 927/1,419 patients were under treatment with thiopurine drugs (65%). A total of 4 patients with IBD type Crohn's disease with idiopathic portal hypertension probably related to the thiopurine treatment were identified (incidence of 4.3 cases per 1,000). Seventy-five percent of patients started with signs or symptoms of portal hypertension. Only one patient was asymptomatic but the diagnosis of IPH because of isolated thrombocytopenia is suspected. However, note that all patients had thrombocytopenia previously. Abdominal ultrasound with fibroscan, hepatic vein catheterization and liver biopsy were performed on all of them as part of the etiology of portal hypertension. In the abdominal ultrasound, indirect portal hypertension data were observed in all patients (as splenomegaly) cirrhosis was also ruled out. The fibroscan data showed significant liver fibrosis (F2-F3).Conclusion: Idiopathic portal hypertension following thiopurine treatment in IBD patients is a rare occurrence, but it must be borne in mind in the differential diagnosis for early diagnosis, especially in patients undergoing thiopurine treatment over a long period. The presence of thrombocytopenia is often the only predictor of its development in the preclinical stage.

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“…The prevalence of primary sclerosing cholangitis is approximately 1-3.4% in CD [39]. Population-based analysis confirmed association between IBD and ankylosing spondylitis, iritis and uveitis, pyoderma gangrenosum and erythema nodosum.…”

Section: Other Extraintestinal Manifestationsmentioning

confidence: 78%

“…The rare but serious side effects [32][33][34] of long-term immunomodulators therapy include the development of non-Hodgkin lymphoma [35][36][37] and hepatosplenic T-cell lymphoma [37][38][39][40][41]. The rare but serious side effects [32][33][34] of long-term immunomodulator therapy include the development of lymphoma [33] and hepatosplenic T-cell lymphoma (HSTCL) [42].…”

Section: Immunomodulators: Azathioprine and 6-mercaptopurinementioning

confidence: 99%

Advances in the Management of Inflammatory Bowel Disease

Koutroubakis¹

2013

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Hepatobiliary disorders and complications of inflammatory bowel disease

Cited by 31 publications

References 146 publications

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease

Advances in the Management of Inflammatory Bowel Disease

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