Hepatoadrenal syndrome in Egyptian children with liver cirrhosis with and without sepsis

El-Faramawy, A.

doi:10.1016/j.ejmhg.2012.04.005

Cited by 2 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While other studies [13,21,22] reported that prevalence rates of adrenal insufficiency (AI) in critically ill patients vary according to the characteristics of the study population and the diagnostic criteria used and rates as high as 60-90% have been documented in patients with septic shock. One study [23] reported that the proportion of relative adrenal insufficiency in children with sepsis (66.6%) was much higher than that without sepsis (25%), which declares the strong association between sepsis and septic shock with relative adrenal insufficiency. Cortisol versus blood pressure in both preterm and full term There was reversed significant correlation between serum cortisol level and both systolic and diastolic blood pressure in preterm and fullterm of group A.…”

Section: Discussion Culture Proved Sepsismentioning

confidence: 98%

New insight of adrenal responses in premature neonates versus full term neonates in critical care setting

razek

Hashem

Osman

2020

Preprint

View full text Add to dashboard Cite

Background: Adequate adrenocortical function is essential for survival of critically ill neonates. Although most of them display elevated plasma cortisol concentrations, which reflects activation of the hypothalamic pituitary adrenal axis (HPA), yet; adrenocortical insufficiency is seen in septic shock. Objectives: Evaluate the HPA response in critically ill neonates with shock. Subjects:this prospective observational study included a total of 60 neonates divided into 3 groups;(A)30 critical ill neonates with septic shock on inotropic support, (B)15 patients with sepsis who did not need inotropic support and(C) control group(n=15). Methods: Adrenal functions were evaluated by taking a single diurnal ACTH reading and two readings for serum cortisol level (diurnal and nocturnal). Results: Gram negative organism was more prevalent among the patients; 53%, 63% in groups A and B respectively. Group A showed Significant statistical hypotension before vasopressor drug administration (p<0.001) as compared to both groups. Group A showed Significant statistical improvement of blood pressure after vasopressor drug administration (p<0.001) as compared to both groups B, C. Serum cortisol was significantly higher in group A(57.21 plus-or-minus sign 24.31) and B (48.01 plus-or-minus sign 18.27 ), while it was lower in group C(19.57plus-or-minus sign 16.05 ) . A highly statistically significant rise of serum cortisol level( p=0.000) and ACTH(p=0.000) in group A when was compared to the other two groupsConclusion: This study introduced a new pattern of serum cortisol response in neonates ranging from very high cortisol level to a near normal values; highlighting a state of glucocorticoid resistance in neonates and relative adrenal insufficiency.

show abstract

Section: Discussion Culture Proved Sepsismentioning

confidence: 98%

New insight of adrenal responses in premature neonates versus full term neonates in critical care setting

razek

Hashem

Osman

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Renal affection of cirrhotic patients is common, hepatorenal syndrome (HRS) is the most studied one (310)(311)(312)(313), HRS in children is a rare presentation (314,315). Also, acute kidney injury in cirrhotic patients is a challenging presentation (316)(317)(318)(319).…”

Section: Liver Cirrhosis and Its Complicationsmentioning

confidence: 99%

Liver diseases among Arab world, current state and unmet needs, a scoping review

Almansoury,

Abdel-Gawad,

Abdelghani

et al. 2023

Global Gastroenterology

View full text Add to dashboard Cite

Hepatoadrenal syndrome in Egyptian children with liver cirrhosis with and without sepsis

Cited by 2 publications

References 22 publications

New insight of adrenal responses in premature neonates versus full term neonates in critical care setting

New insight of adrenal responses in premature neonates versus full term neonates in critical care setting

Liver diseases among Arab world, current state and unmet needs, a scoping review

Contact Info

Product

Resources

About