Hepato-, Nephro- and Pancreatoprotective Effect of Derivatives of Drug Xymedon with Biogenic Acids Under Toxic Influence of Carbon Tetrachloride in Rats

Vyshtakalyuk, A. B.; Парфенов, А. А.; Назаров, Н. Г.; Gumarova, L. F.; Черепнев, Г. В.; Galyametdinova, I. V.; Зобов, В. В.; Семенов, В. Э.

doi:10.1007/s12668-018-0526-3

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Гистологическую проводку, приготовление парафиновых срезов, окрашивание гематоксилином Гарриса (BioVitrum, Россия), спиртовым эозином (BioVitrum, Россия) осуществляли по стандартным протоколам, более подробно описанным в работах [4][5][6][7][8][9]. Приготовление замороженных срезов и окрашивание их суданом 4 (BioVitrum, Россия) также выполняли по стандартным протоколам.…”

Section: гистологические исследованияunclassified

“…Несвоевременно начатое лечение легких форм патологий печени, вызванных действием гепатотоксических веществ, может привести к более серьезным, вплоть до некротических повреждений [1]. Объектом настоящего исследования были лекарственный препарат на основе производного Ранее были получены данные, которые показали, что конъюгирование Ксимедона с некоторыми биологически активными кислотами приводит к усилению протекторного действия самой молекулы Ксимедона [3][4][5][6][7][8][9].…”

Section: Introductionunclassified

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Anti-Apoptosis Mechanism of the Hepatoprotective Effect of Pyrimidine Derivatives in In Vivo Studies

Parfenov¹,

Vyshtakalyuk²,

Semenov³

et al. 2022

Uch. Zap. Kazan. Univ. Ser. Estestv. Nauki

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This study investigates the effect of pyrimidine derivatives (Xymedon and its conjugate with L-ascorbic acid, both exhibiting hepatoprotective activity) on the apoptosis of rat liver cells against the background of exposure to carbon tetrachloride as a hepatotoxic agent. The characteristic markers of apoptosis affected by the considered compounds were identified. Modern multiplex analysis of the early apoptosis markers Akt, BAD, BCL-2, p53, Active Caspase-8, and Active Caspase-9 in rat liver homogenates using the MagPix

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Section: гистологические исследованияunclassified

Section: Introductionunclassified

Anti-Apoptosis Mechanism of the Hepatoprotective Effect of Pyrimidine Derivatives in In Vivo Studies

Parfenov¹,

Vyshtakalyuk²,

Semenov³

et al. 2022

Uch. Zap. Kazan. Univ. Ser. Estestv. Nauki

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“…The control group was administered with water. At the end of the course of administration, the animals were euthanized, similarly to the study 19,20 , after which the stomach was removed. The ulcerogenic effect was studied according to work 21 the stomachs were opened along the lesser curvature, cleaned of the contents, washed with saline, and immediately examined the state of the mucosa under a stereomicroscope.…”

Section: Estimate Of the Ulcerogenic Effectmentioning

confidence: 99%

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2020

IJPSR

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The aim of this work is a comparison of antiinflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties. INTRODUCTION: Studies in the development of anti-inflammatory drugs confirm their high relevance and take place in novel world literature 1, 2 .

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“…[ 2,3 ] The authors of this paper previously have shown that xymedon and its derivatives possessed hepatoprotective, antioxidant, neuroprotective, and other properties. [ 4–8 ]…”

Section: Introductionmentioning

confidence: 99%

Conjugate of pyrimidine derivative, the drug xymedon with succinic acid protects liver cells

Vyshtakalyuk

Парфенов

Gumarova

et al. 2020

J Biochem & Molecular Tox

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The aim of the study was to investigate the hepatoprotective properties of the conjugate of the xymedon drug substance with succinic acid (1a). The study presents an in vitro comparative evaluation of the cytotoxicity and cytoprotective properties of 1a and succinic acid on a cell line of normal human hepatocytes Chang Liver, and in vivo investigation of the ability of 1a to restore liver from the toxic damage caused by CCl4 in Wistar rats. It was shown that the cytotoxicity of 1a was 19.9 ± 0.8 mmol/L, and that of succinic acid was 14.1 ± 0.2 mmol/L. Against the background of d‐galactosamine exposure, the cytoprotective effect of 1a was found to be superior to that of succinic acid. It was shown that 1a caused a significant reduction in necrotic and steatosis changes in the liver and restoration of biochemical markers of cytolysis, as well as bilirubin metabolism and synthetic liver function.

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Hepato-, Nephro- and Pancreatoprotective Effect of Derivatives of Drug Xymedon with Biogenic Acids Under Toxic Influence of Carbon Tetrachloride in Rats

Cited by 5 publications

References 24 publications

Anti-Apoptosis Mechanism of the Hepatoprotective Effect of Pyrimidine Derivatives in In Vivo Studies

Anti-Apoptosis Mechanism of the Hepatoprotective Effect of Pyrimidine Derivatives in In Vivo Studies

Untitled

Conjugate of pyrimidine derivative, the drug xymedon with succinic acid protects liver cells

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