Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains

Zidan, Nour El-Hoda A.

doi:10.1556/018.66.2015.2.1

Cited by 18 publications

(8 citation statements)

References 34 publications

(20 reference statements)

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“…Some producers have cholesterol levels that are higher than normal. This is consistent with data from [32] who found in rats exposed to malathion and spinosad an increase in cholesterol levels and several other biochemical parameters such as ALT, AST, ALP and ACP. The increase in triglyceride levels in some individuals is supported by [33] as well as [14] in wistar rats exposed to malathion and in Astacus leptodactylus exposed to chlorpyrifos and glyphosate.…”

Section: Discussionsupporting

confidence: 93%

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Bayili

Da²,

Ilboudo

et al. 2020

GSC Biol. and Pharm. Sci.

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Repeated exposure to pesticides can cause a variety of human health problems, particularly among farmers. This work consisted in studying biochemical parameters and their evolution in cotton farmers exposed to pesticides. A longitudinal study was conducted during and after the 2018/2019 cotton season on a cohort of cotton farmers around the Bala hippopotamus pond in the department of Satiri. Biochemical parameters were measured during and after the crop year on the Architect ci 4100. The majority of the farmers had high uric acid (UA) and low blood sugar (Gluc) concentrations. A few had concentrations of Cholinesterase (ChE) (6.19%); Direct Bilirubin (BilD) (23.01%); Gamma Glutamyl Transferase (GGT) (8.85%); Alkaline Phosphatase (ALkP) (4.42%); Cholesterol (Chol) (4.42%); triglycerides (Trig) (4.42%); aspartate aminotransferase (AST) (4.42%) higher than normal and lower than normal albumin (Alb) (13.27%) and total protein (TP) (13.27%) concentrations. Analysis of the evolution of biochemical parameters showed that none of the producers had higher than normal ChE and TP concentrations. After the campaign, the number of producers with lower than normal values increased for AST, AlkP, Alb and Urea while those with higher than normal values increased for GGT, UA, Gluc, Chol, Trig and BilD. Also, a significant decrease in AST, ALT and creatinine (CreaC) concentrations and a significant increase in GGT and BilD concentrations were observed. The existence of some disturbances of biochemical parameters in farmers should encourage to test the hypothesis of a link between pesticide exposure and the appearance of biochemical disorders in clinical trials.

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Section: Discussionsupporting

confidence: 93%

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Bayili

Da²,

Ilboudo

et al. 2020

GSC Biol. and Pharm. Sci.

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“…The kidney is one of the target organs that are attacked by OP compounds' toxicity. MAL-treated rats showed upregulation of renal function tests, serum creatinine, urea, and uric acid (Zidan 2015;Selmi et al 2015). Histopathologically, MAL treatment induced renal degenerative changes including cloudy swelling and cellular desquamations, as well as swollen and pleomorphic mitochondria (Keadtisuke et al 1989;Al-Attar 2010).…”

Section: Malathion-induced Nephrotoxicitymentioning

confidence: 96%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

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Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation of apoptotic cell damage. Exposure to malathion has been associated with different toxicities that nearly affect every single organ in our bodies, with CNS toxicity being the most well documented. Malathion toxic effects on liver, kidney, testis, ovaries, lung, pancreas, and blood were also reported. Moreover, malathion was considered as a genotoxic and carcinogenic chemical compound. Evidence exists for adverse effects associated with prenatal and postnatal exposure in both animals and humans. This review summarizes the toxic data available about malathion in mammals and discusses new potential therapeutic modalities, with the aim to highlight the importance of increasing awareness about its potential risk and reevaluation of the allowed daily exposure level.

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“…In rats, after malathion poisoning, there is an increase in functional renal tests, serum creatinine, urea, and uric acid [ 202 , 203 ]. An increase in creatinine and urea concentrations in plasma or serum of rats after OPs poisoning at different doses has been observed for many members of this group of chemicals, at different times of observation and with different routes of administration.…”

Section: Molecular Pathophysiological Mechanisms Of Organophosphate N...mentioning

confidence: 99%

Molecular Mechanisms of Acute Organophosphate Nephrotoxicity

Соболев

Sokolova

Jenkins

et al. 2022

IJMS

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Organophosphates (OPs) are toxic chemicals produced by an esterification process and some other routes. They are the main components of herbicides, pesticides, and insecticides and are also widely used in the production of plastics and solvents. Acute or chronic exposure to OPs can manifest in various levels of toxicity to humans, animals, plants, and insects. OPs containing insecticides were widely used in many countries during the 20th century, and some of them continue to be used today. In particular, 36 OPs have been registered in the USA, and all of them have the potential to cause acute and sub-acute toxicity. Renal damage and impairment of kidney function after exposure to OPs, accompanied by the development of clinical manifestations of poisoning back in the early 1990s of the last century, was considered a rare manifestation of their toxicity. However, since the beginning of the 21st century, nephrotoxicity of OPs as a manifestation of delayed toxicity is the subject of greater attention of researchers. In this article, we present a modern view on the molecular pathophysiological mechanisms of acute nephrotoxicity of organophosphate compounds.

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Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains

Cited by 18 publications

References 34 publications

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Molecular Mechanisms of Acute Organophosphate Nephrotoxicity

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