Hepatitis viruses in southern taiwan—mass survey of 2985 inhabitants

Chiou, Shue-Shian; Obata, Hiroshi; Takasaki, Tomohiko; Fukushima, Yasuhiko; Motoike, Yoji; Okuda, Hiroyuki; Tanaka, Seiichi; Kurihara, Takashi; Tomimatsu, Masahiko; Kobayashi, Seiichiro; Shimizu, Satoru; Yuan, Chung-Yin; Wei, Tzu-Tang

doi:10.1007/bf02779124

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…In this study we found the Taiwanese who were born after the implementation of nationwide disposable (Table 4), and a prevalence rate up to 98% in the age group 20 to 29 was found in blood samples collected between November 1981 and February 1982 in the study covering the whole southern Taiwan [15]. The Tainan area is in the southern part of Taiwan, and the Taipei area is in the northern part of Taiwan.…”

Section: Discussionmentioning

confidence: 69%

“…From the review of literature, we found three studies reporting age-specific seroprevalence rates of anti-HAV IgG in the Tainan area [7,8,12], six in the Taipei area [3,4,6,[12][13][14], and one covering the whole southern Taiwan [15]. All the three studies in the Tainan area found that the seroprevalence generally increased with age, which was similar to the trends observed in the current study [6][7][8] (Table 2).…”

Section: Resultsmentioning

confidence: 99%

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Decrease in Seroprevalence of Hepatitis A after the Implementation of Nationwide Disposable Tableware Use in Taiwan

Su¹,

Guo²

2009

Epidemiology

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Background: Taiwan is an endemic area of viral hepatitis, including hepatitis A, which is transmitted mainly from the fecal-oral route. In order to reduce the transmission through food intake, the government implemented a policy of nationwide disposal tableware use in public eating places in 1982. We conducted a study to estimate the seroprevalence of Hepatitis A in a group of workers in Taiwan in 2005, determine the risk factors, and compare seroprevalence to published estimates in Taiwan to evaluate changes in the seroprevalence after the implementation of the nationwide disposal tableware use. Methods: We recruited workers of an industrial park during their annual health examinations in 2005 and measured their anti-hepatitis A virus IgG titer using microparticle enzyme immunoassay. We compared the seroprevalence across different birth cohorts within the study population and also analyzed data from previous studies.

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Section: Discussionmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Decrease in Seroprevalence of Hepatitis A after the Implementation of Nationwide Disposable Tableware Use in Taiwan

Su¹,

Guo²

2009

Epidemiology

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“…[4][5][6][7][8][9][10][12][13][14][15][16][17]23,24,[27][28][29][30][31] Prior to mass HB vaccination, Taiwan had the highest HBV infection rate in Asia. 16,24 Infants born prior to the universal HB vaccination were at high risk of being vertically infected with HBV by their mothers who were seropositive for either HBsAg or HBeAg. CHB caused by HBV is the primary risk factor for hepatocellular carcinoma (HCC), 8,25 and HCC is a major cause of death in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

“…doi:10.1016/j.jcv.2011.06.012 tion in Taiwan, 4,8,[14][15][16][17] Italy, 18 Malaysia, 19 South Africa, 20 and Thailand. 21,22 However, few papers have investigated the relationship between HB seroprevalence and the risk of liver bio-functions responding to vaccine.…”

Section: Objectivesmentioning

confidence: 99%

Efficacy of the nationwide hepatitis B infant vaccination program in Taiwan

Chen

Kung

Yang

et al. 2011

Journal of Clinical Virology

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“…Taiwan is a hyperendemic area for HBV infection [16,17]. Most adults in the area have been infected by HBV during childhood.…”

Section: Introductionmentioning

confidence: 99%

Superinfection with Hepatitis C Virus in Hemodialysis Patients with Hepatitis B Surface Antigenemia: Its Prevalence and Clinical Significance in Taiwan

Chen

Lo²,

Liao³

et al. 1996

Nephron

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A survey of hepatitis B surface antigen (HB_sAg) and antibodies against hepatitis C virus (anti-HCV) in 173 patients undergoing hemodialysis in Taiwan revealed that 15 (9%) patients were positive for both HB_sAg and anti-HCV, 106 (61%) were positive for anti-HCV alone, and 14 (8%) were positive for HB_sAg alone. Most HB_sAg positivity was acquired before the onset of hemodialysis. Anti-HCV positivity, however, was mainly acquired via the hemodialysis procedure. Patients with dual markers were younger (43.7 ± 3.3 years old, p = 0.0274), had the longest period on hemodialysis (6.6 ± 1.3 years, p < 0.001), and more severe liver dysfunction. When compared with those who were negative for both markers, patients with both HB_sAg and anti-HCV had an increased incidence of chronicity (5/15 vs. 2/38; p < 0.05), ultrasonographic cirrhosis (5/15 vs. 1/38; p < 0.05), and clinical decompensation (2/15 vs. 0/38; p < 0.05). Their risk for developing ultrasonographic cirrhosis and clinical decompensation was also greater than that of patients with anti-HCV alone (5/15 vs. 8/106 and 2/15 vs. 2/106; p < 0.05 for both). The presence of HB_sAg alone, however, did not increase the incidence of liver dysfunction. The presence of anti-HCV alone was only associated with a greater elevation of serum alanine aminotransferase (44.2 ± 5.5 vs. 19.1 ± 2.5 U/l; p < 0.05) and an increased incidence of chronicity (30/106 vs. 2/38; p < 0.05). Our results indicate that a high prevalence of HCV superinfection impose a significant risk on a large population of HB_sAg-positive hemodialysis patients in Taiwan. As the coexistence of anti-HCV and HB_sAg is associated with more severe liver dysfunction, it is urgent to devise effective methods to prevent HCV circulation in a hemodialysis environment – especially in a hepatitis B virus endemic area such as Taiwan.

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Hepatitis viruses in southern taiwan—mass survey of 2985 inhabitants

Cited by 9 publications

References 24 publications

Decrease in Seroprevalence of Hepatitis A after the Implementation of Nationwide Disposable Tableware Use in Taiwan

Decrease in Seroprevalence of Hepatitis A after the Implementation of Nationwide Disposable Tableware Use in Taiwan

Efficacy of the nationwide hepatitis B infant vaccination program in Taiwan

Superinfection with Hepatitis C Virus in Hemodialysis Patients with Hepatitis B Surface Antigenemia: Its Prevalence and Clinical Significance in Taiwan

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