Hepatitis: Sedation and Anesthesia Implications

Chen, Gina; Cheung, Ryan; Tom, James W.

doi:10.2344/anpr-64-02-13

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Albumin is the main protein circulating in the blood, yet only formed by the liver [34]. The lower albumin level in patients with severe fibrosis is in accordance with several studies that reported similar results [35][36][37][38][39].…”

Section: Discussionsupporting

confidence: 89%

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Mohamed¹,

Hemeda²,

Aziz³

et al. 2020

Futur J Pharm Sci

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Background Viral hepatitis is the seventh leading cause of mortality globally, and half of this mortality is attributed to hepatitis C virus (HCV). Egypt has the highest HCV prevalence worldwide, with an estimated 14.7% of the population being HCV-positive. HCV infection is the primary cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma. Liver fibrosis varies in severity during chronic HCV infection, and 10–20% of chronic hepatitis C (CHC) patients with severe fibrosis develop cirrhosis. The goal of this work was to assess the clinico-demographic predictors of severity of HCV-induced fibrosis in a cohort of Egyptian patients. Results A cohort of Egyptian patients with chronic HCV genotype 4a infection showed significant association between severe fibrosis stages and obesity, represented by a higher body mass index (BMI), low albumin level, high alpha-fetoprotein (AFP) level, low thyroid-stimulating hormone (TSH) level, and high alkaline phosphatase (ALP) level. Multivariate analysis delineated BMI, TSH, and ALP as independent significant variables that could predict the risk of fibrosis severity in HCV infections. Conclusion This study argues in favor of using the biomarker profile of CHC patients infected with HCV genotype 4a to identify patients at higher risk of developing severe fibrosis, which is a necessary first step towards precision medicine via patient stratification.

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Section: Discussionsupporting

confidence: 89%

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Mohamed¹,

Hemeda²,

Aziz³

et al. 2020

Futur J Pharm Sci

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“…Hepatitis is a systemic disease primarily involving the liver as a main target for viral replication which characterized clinically by fever, jaundice and gastrointestinal symptoms ( [8,35].There is a variety of agents in addition to the viruses that cause liver inflammation (hepatitis) such as bacteria, parasites, fungi and chemical agents including drugs, toxins and alcohol [25,12].Viral hepatitis is a disease of multiple causes that has been first described in the 5th century B.C when Hippocrates described epidemic jaundice. The recognition a form of hepatitis that has been transmitted by direct inoculation of blood [47,5] or blood products have been first document by Lurman, Germany in (1883), then the discovery of the etiological agent for hepatitis B and the development of safe and effective vaccines for this virus are among the remarkable scientific achievements of the 20th century [38,22].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Assessment As Markers For Diagnosis And Evaluation Hepatitis B Virus (HBV)

Al-Salih

Abed²,

Samsudin³

2021

Al-Qadisiyah Journal of Pure Science

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This paper summarizes assessment biochemical markers of the development of hepatitis B viruses (HBV), in which any possible connection between certain biochemical parameters and chronic hepatitis was identified. Liver function tests are helpful in diagnosing liver disease and dysfunction, assessing severity, tracking treatment, and determining prognosis. According to the findings of biochemical studies, chronic patients have higher levels of ALP, GPT, GOT, and TSB than carriers. The rise in liver enzymes strongly indicates hepatocellular damage, despite the fact that ALP, GPT, GOT, and TSB levels in the carrier group were all within normal parameters as compared to the reference group. Testing liver function in terms of protein level, albumin, and globulin, the concentration of protein profiles in chronic patients is clearly decreasing as compared to the carrier group. In severe or long-lasting liver disease, the significant decreasing profile of serum proteins is evident in some conditions, the release of tumor necrosis factor hampers the synthesis of albumin, however, induce the synthesis of the acute phase response, hypoalbuminemia is multifactorial, while the hepatic synthesis of albumin is decreased in liver disease.

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“…Hepatitis or liver inflammation is one of the most common liver diseases that imposes a heavy global health burden . Acute hepatitis is either self‐resolving or develops into chronic hepatitis and subsequently progresses to cirrhosis or hepatocellular carcinoma (HCC) . The main etiologies include infection, metabolism, and autoimmune‐related causes.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections

Zhang

et al. 2019

Reviews in Medical Virology

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Summary Hepatitis virus infections affect a large proportion of the global population. The host responds rapidly to viral infection by orchestrating a variety of cellular machineries, in particular, the mitochondrial compartment. Mitochondria actively regulate viral infections through modulation of the cellular innate immunity and reprogramming of metabolism. In turn, hepatitis viruses are able to modulate the morphodynamics and functions of mitochondria, but the mode of actions are distinct with respect to different types of hepatitis viruses. The resulting mutual interactions between viruses and mitochondria partially explain the clinical presentation of viral hepatitis, influence the response to antiviral treatment, and offer rational avenues for novel therapy. In this review, we aim to consider in depth the multifaceted interactions of mitochondria with hepatitis virus infections and emphasize the implications for understanding pathogenesis and advancing therapeutic development.

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Hepatitis: Sedation and Anesthesia Implications

Cited by 8 publications

References 15 publications

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Biochemical Assessment As Markers For Diagnosis And Evaluation Hepatitis B Virus (HBV)

Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections

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