1976
DOI: 10.1016/s0016-5085(76)80464-7
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Hepatitis in an Adult Caused by Herpes Simplex Virus Type I

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Cited by 42 publications
(8 citation statements)
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“…The one observed in the two patients who survived (5,15) is characterized by dense inflammatory cell infiltrates in contact with necrotic foci; these infiltrates were found early in the course of the disease; this inflammatory pattern of HSV liver necrosis attests healing and adequately restrained HSV lesions (26). The other pattern, observed in our patient and in seven other fatal cases (6,8,9,14,16,17,21), is characterized by the absence or paucity of the inflammatory cell infiltrates in contact with necrotic foci. In these eight adults, the serum transaminases level was markedly higher than that reported in the two adults who recovered (5,15) and, as in neonates (25), non-inflammatory HSV liver necrosis was often extensive.…”
Section: Discussionsupporting
confidence: 56%
See 1 more Smart Citation
“…The one observed in the two patients who survived (5,15) is characterized by dense inflammatory cell infiltrates in contact with necrotic foci; these infiltrates were found early in the course of the disease; this inflammatory pattern of HSV liver necrosis attests healing and adequately restrained HSV lesions (26). The other pattern, observed in our patient and in seven other fatal cases (6,8,9,14,16,17,21), is characterized by the absence or paucity of the inflammatory cell infiltrates in contact with necrotic foci. In these eight adults, the serum transaminases level was markedly higher than that reported in the two adults who recovered (5,15) and, as in neonates (25), non-inflammatory HSV liver necrosis was often extensive.…”
Section: Discussionsupporting
confidence: 56%
“…From our case and from the other nine cases reported in adults with detailed description of liver lesions (5,6,8,9,(14)(15)(16)(17)21), two patterns of HSV liver lesions can be distinguished. The one observed in the two patients who survived (5,15) is characterized by dense inflammatory cell infiltrates in contact with necrotic foci; these infiltrates were found early in the course of the disease; this inflammatory pattern of HSV liver necrosis attests healing and adequately restrained HSV lesions (26).…”
Section: Discussionmentioning
confidence: 57%
“…HSV hepatitis was the cause of the acute failure of the first graft. The natural course of HSV hepatitis is usually rapidly fatal, and diagnosis is mostly made postmortem 13. Comparably, in this case high‐dose intravenous acyclovir was administered immediately after diagnosis but did not prevent acute liver failure due to extensive parenchymal necroses.…”
Section: Discussionmentioning
confidence: 84%
“…As early as 1976 Eron et al 38 suggested that a search should be made for visible vesicular lesions (mouth, pharynx, esophagus, skin, genital tract) in the diagnosis of HSV hepatitis; "these should be smeared for giant cells and intranuclear inclusions, as well as appropriately cultured for virus." Results of Tzanck smears or fluorescent antibody testing of air-dried smears or touch preparations of the lesions are usually available in a matter of hours.…”
Section: Discussion and Review Of Literaturementioning
confidence: 99%
“…Cutaneous and cervical lesions were identified on post- mortem examination of case 1. 25 In the non-pregnant group, m-c involvement was identified in 21 (72%) patients of whom, 4 [36][37][38]50 were only discovered at post-mortem (see Table 4). The vagina and cervix were not examined in case 2, but the patient had a recent past history of genital herpes and presented with dysuria.…”
Section: Are M-c Lesions Present In Patients With Hs Hepatitis?mentioning
confidence: 99%