Hepatitis G virus: What is the next step?

Wright, T L

doi:10.1002/lt.500030625

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Although children with ongoing infection had slightly elevated serum ALT levels in comparison to controls [median (IQR) 27 (21.7-33) Vs 23 (20.5-28) U/L; respectively); this was not statistically significant. HGV infection was reported to be associated with acute [15-17] up to fulminant hepatitis [18-21]. On the contrary; other researchers have suggested that in most instances HGV infection does not cause an elevation of ALT levels [37].…”

Section: Discussionmentioning

confidence: 99%

“…Although HGV infection appears to be not associated with severe hepatic damage; however a possible link between HGV infection and acute [15-17], fulminant hepatitis [18-21], chronic (mild and moderate) hepatitis [22,23] or even hepatic fibrosis [24] has been suggested. This study was done to assess the frequency of HGV exposure (ongoing & past infection) in Egyptian children with CRF and to correlate viral exposure with age, sex, duration of disease, frequency of blood transfusion, and co infection with HBV & HCV and to study the effect of ongoing viral infection on hepatic biochemical parameters in these children.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis G virus infection in Egyptian children with chronic renal failure (single centre study)

Hammad

Zaghloul

2009

Annals of Clinical Microbiology and Antimicrobials

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BackgroundHepatitis G virus (HGV) is an RNA virus. It is mainly transmitted through exposure to contaminated blood although other routes may also exist. Patients with chronic renal failure (CRF) are at high risk of acquiring HGV because they require frequent blood transfusions. Ongoing HGV infection can be only diagnosed by demonstrating viremia in patient sample by reverse transcriptase (RT) PCR. Antibodies to the envelop protein E2 (anti E2) of HGV is an indicator of virus clearance and testify past HGV contact. This cross sectional study was done to assess the frequency of HGV exposure (ongoing and past infection) in Egyptian children with CRF and to study the possible risk factors of infection.MethodsThis study included 100 children with CRF [34 on regular haemodialysis (HD) and 66 before the start of dialysis (predialysis)]. All patients sera were tested for HGV RNA by RT-PCR, anti E2, hepatitis C virus (HCV) antibody, hepatitis B surface antigen (HBsAg), and hepatitis B core antibody (HBcAB). Twenty five healthy children of matched age & sex were used as controls.ResultsHGV RNA was positive in 9 (26.5%) of HD and 9 (13.6%) of predialysis children. Anti E2 was positive in 14 (41.2%) of HD and 19 (28.8%) of predialysis children.In comparison to controls; CRF (n = 100); HD and predialysis children had significantly higher prevalence of anti E2 [4% VS 33% for all CRF cases; (p = 0.002)& 41.2% (p = 0.002) and 28.8% (p = 0.01); for HD and predialysis groups; respectively]. HGV RNA was significantly more prevalent only in HD children in comparison to controls (p = 0.03). HD and predialysis children did not have significant difference in the prevalence of HGV RNA (p = 0.16) or anti E2 (p = 0.26).HGV exposure was not correlated with positivity of anti HCV (p = 0.32), HCV RNA (0.09), HBsAg/HBcAB (p = 1), age (p = 0.06), or gender (p = 0.83). It was significantly correlated with duration of the disease (p < 0.001). Ongoing HGV infection was significantly more prevalent with frequent blood transfusion (p < 0.001). There were no significant differences in serum levels of ALT (p = 0.09), total bilirubin (p = 0.1) and albumin (p = 0.06) in children with ongoing infection in comparison to healthy controls.ConclusionsThe frequency of HGV exposure in Egyptian children with CRF appears to be high and is mainly related to frequent blood transfusions and longer disease duration. HGV infection in these children is not associated with significant changes in hepatic biochemical parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatitis G virus infection in Egyptian children with chronic renal failure (single centre study)

Hammad

Zaghloul

2009

Annals of Clinical Microbiology and Antimicrobials

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Hepatitis G virus

Reshetnyak

Карлович²,

Ilchenko³

2008

WJG

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A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an "accidental tourist" that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine.

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Hepatitis G virus: What is the next step?

Cited by 2 publications

References 17 publications

Hepatitis G virus infection in Egyptian children with chronic renal failure (single centre study)

Hepatitis G virus infection in Egyptian children with chronic renal failure (single centre study)

Hepatitis G virus

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