Hepatitis E Virus Genotype 3 in Humans and Swine, Bolivia

Dell’Amico, Maria Chiara

doi:10.3201/eid1708.100769

Cited by 32 publications

(30 citation statements)

References 13 publications

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“…HEV was also reported in sewage and river waters, confirming the virus circulation in environmental waters in some countries (7,(43)(44)(45). Considering the zoonotic potential of distribution of this virus from various animal species, environmental transmission needs to be considered (5,8,46,47). Despite our effort to select contaminated areas, we failed to detect any positive samples for HEV.…”

Section: Discussionmentioning

confidence: 43%

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

Grodzki

Schaeffer

Piquet

et al. 2014

Appl Environ Microbiol

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dHepatitis E virus (HEV), an enteric pathogen of both humans and animals, is excreted by infected individuals and is therefore present in wastewaters and coastal waters. As bivalve molluscan shellfish are known to concentrate viral particles during the process of filter feeding, they may accumulate this virus. The bioaccumulation efficiencies of oysters (Crassostrea gigas), flat oysters (Ostrea edulis), mussels (Mytilus edulis), and clams (Ruditapes philippinarum) were compared at different time points during the year. Tissue distribution analysis showed that most of the viruses were concentrated in the digestive tissues of the four species. Mussels and clams were found to be more sensitive to sporadic contamination events, as demonstrated by rapid bioaccumulation in less than 1 h compared to species of oysters. For oysters, concentrations increased during the 24-h bioaccumulation period. Additionally, to evaluate environmental occurrence of HEV in shellfish, an environmental investigation was undertaken at sites potentially impacted by pigs, wild boars, and human waste. Of the 286 samples collected, none were contaminated with hepatitis E virus, despite evidence that this virus is circulating in some French areas. It is possible that the number of hepatitis E viral particles discharged into the environment is too low to detect or that the virus may have a very short period of persistence in pig manure and human waste.

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Section: Discussionmentioning

confidence: 43%

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

Grodzki

Schaeffer

Piquet

et al. 2014

Appl Environ Microbiol

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“…América Latina se considera una región de baja endemia, con excepción de México. La infección por HEV se ha descrito en diferentes poblaciones de Brasil (21)(22)(23)(24)(25)30,38), Argentina (39,40), Venezuela (32,35,41), Bolivia (26,31,34,42), Chile (27,43) Teniendo en cuenta el pico de incidencia de la infección por HEV en pacientes de 15 a 35 años de edad descrito en la literatura científica, en el grupo 2 se incluyeron muestras de pacientes con 15 años o más de edad (54,55). Una diferencia adicional entre los grupos consistió en que 31,9 % (29/91) de las muestras del grupo 2 fueron positivas para el marcador de infección aguda por HAV (IgM anti-HAV), muestras que no se excluyeron en el presente análisis.…”

Section: Discussionunclassified

Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia

et al. 2014

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“…2). HEV-3 is prevalent among swine worldwide (71)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86) as well as in other mammals, including deer and mongooses (83,(87)(88)(89), though little is known about the sylvatic circulation of HEV.…”

Section: Epidemiologic Patterns Of Hepatitis E Virus Infectionmentioning

confidence: 99%

Host Immune Status and Response to Hepatitis E Virus Infection

2014

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SUMMARY Hepatitis E virus (HEV), identified over 30 years ago, remains a serious threat to life, health, and productivity in developing countries where access to clean water is limited. Recognition that HEV also circulates as a zoonotic and food-borne pathogen in developed countries is more recent. Even without treatment, most cases of HEV-related acute viral hepatitis (with or without jaundice) resolve within 1 to 2 months. However, HEV sometimes leads to acute liver failure, chronic infection, or extrahepatic symptoms. The mechanisms of pathogenesis appear to be substantially immune mediated. This review covers the epidemiology of HEV infection worldwide, the humoral and cellular immune responses to HEV, and the persistence and protection of antibodies produced in response to both natural infection and vaccines. We focus on the contributions of altered immune states (associated with pregnancy, human immunodeficiency virus [HIV], and immunosuppressive agents used in cancer and transplant medicine) to the elevated risks of chronic infection (in immunosuppressed/immunocompromised patients) and acute liver failure and mortality (among pregnant women). We conclude by discussing outstanding questions about the immune response to HEV and interactions with hormones and comorbid conditions. These questions take on heightened importance now that a vaccine is available.

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Hepatitis E Virus Genotype 3 in Humans and Swine, Bolivia

Abstract: We determined the seroprevalence of hepatitis E virus (HEV) in persons in 2 rural communities in southeastern Bolivia and the presence of HEV in human and swine fecal samples. HEV seroprevalence was 6.3%, and HEV genotype 3 strains with high sequence homology were detected.

Cited by 32 publications

References 13 publications

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia

Host Immune Status and Response to Hepatitis E Virus Infection

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