Hepatitis E Virus Antibodies in Hemodialysis Patients: An Epidemiological Survey in Central Greece

Stefanidis, Ioannis; Zervou, Eleftheria; Rizos, C.; Syrganis, Christos; Patsidis, Eftichios; Kyriakopoulos, George; Sdrakas, Lambros; Tsianas, Nikolaos; Rigopoulou, Eirini I.; Liakopoulos, V.; Dalekos, George Ν.

doi:10.1177/039139880402701005

Cited by 47 publications

(43 citation statements)

References 24 publications

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“…However, haemodialysis patients in four different studies [57,[96][97][98], those who had undergone minor surgery and abdominal surgery in Spain [4], healthcare workers in emergency admission and surgery in Germany [99] and male prisoners and drug treatment patients in Denmark [56] were found to have a higher anti-HEV IgG prevalence than the reference group.…”

Section: Potential For Parenteral Transmissionmentioning

confidence: 99%

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

2009

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SUMMARYIncreasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years. Our objective was to review the evidence on risk factors and transmission routes of autochthonous HEV infection and hepatitis E in Europe in order to develop recommendations for future research, prevention and control. A systematic literature review was performed to identify all primary reports and studies published during 1998-2008 on hepatitis E in humans and animals in Europe by searching Pubmed, reference lists of major articles and international conference proceedings. Each of the 106 included studies was categorized into one of three evidence levels (EL) based on study design and diagnostic methodology. The evidence was generally weak (73 were assigned to EL1, two to both EL1 and EL2, and 30 to EL2), further compounded by the use of poorly validated serological assays in some studies. Only one casecontrol study was assigned to EL3. Persons with autochthonous hepatitis E infection were on average older than the general population and predominantly male. There was no evidence for one main transmission route of HEV infection or risk factor for hepatitis E. However, zoonotic transmission seemed likely and person-to-person transmission too inefficient to cause clinical disease. Multiple routes of transmission probably exist and should be further investigated through analytical studies and reliable diagnostic kits. Based on current evidence that points to zoonotic transmission from pigs, thorough cooking of all porcine products, prevention of crosscontamination in the kitchen and improved education for occupationally exposed people (e.g. pig farmers, veterinarians and sewage workers) may help prevent HEV infection. Although evidence for parenteral transmission is limited, it is recommended that a risk assessment is undertaken.

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Section: Potential For Parenteral Transmissionmentioning

confidence: 99%

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

2009

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“…Başlıca fekal-oral yolla bulaşan, parenteral ve vertikal yolla da bulaşabileceği bildirilen hepatit E virüsünün prevalansının da hemodiyaliz hastalarında normal popülasyondan daha yüksek olduğu bildirilmiştir [8][9][10][11].…”

Section: Discussionunclassified

“…Hemodiyaliz hastalarında hepatite neden olan hepatit E (HEV), Hepatit G (HGV) , transfüzyonla bulaşan virus (TTV) viruslerinin sıklığına ilişkin çeşitli çalışmalar yapılmıştır ve Transfusion transmitted virus (TTV)'un bulaş yolu tam olarak aydınlatılamasa da, hemodiyaliz hastalarında TTV seroprevalansı %9,3-83 arasında değişmektedir [3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionunclassified

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The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

et al. 2017

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ÖzAmaç: Hemodiyaliz hastaları kan, kan ürünleri, perkütan yaralanma veya fekal-oral yolla bulaşabilen hepatit virüs-leri açısından risk grubunda yer alır. Bu çalışmada, hemodiyaliz hastalarında Hepatit E, Hepatit G ve TTV seropozitifliğinin belirlenmesi amaçlandı. Gereç ve Yöntemler:Çalışmaya 66 hemodiyaliz hastası (30 kadın, 36 erkek) ve 66 kontrol (43 kadın, 23 erkek) olmak üzere toplam 132 kişi dahil edildi. Çalışmada anti-HEV, anti HGV ve anti-TTV IgG düzeyleri ELISA yöntemi ile çalışıldı. İstatistiksel analizler SPSS programı ile yapıldı. Elde edilen sonuçların istatistiksel değerlendirilme-sinde Students t testi, Fischer exact testi ve Mann Whitney-U testleri kullanıldı. P < 0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya alınan 66 hasta ve 66 sağlıklı kontrol grubunun yaş ortalaması sırasıyla; 54,9 ve 47,2 idi. Hasta ve kontrol grubunun yaş ortalaması karşılaştırıldığında hasta grubunun yaş ortalaması daha yüksekti.Anti-TTV IgG ve anti-HEV IgG pozitifliği hemodiyaliz hastalarında kontrol grubuna göre daha yüksek bulundu. Hasta ve kontrol grubunda anti-HGV IgG pozitifliği tespit edilmedi. Hemodiyaliz hasta grubunda anti-TTV IgG ve anti-HEV IgG pozitifliği ile hemodiyaliz süresi, yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.Sonuç: Hemodiyaliz hastaları, TTV, hepatit E virüsü ve diğer hepatit virüslerinin bulaşı açısından yüksek risk taşırlar. Bu nedenle, hemodiyaliz ünitelerde temizlik ve dezenfeksiyon kurallarına uyulması HEV ve TTV gibi hepatit virüslerinin bulaşını önlemek için gereklidir.

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“…Reports from Japan, Saudi Arabia and Greece have demonstrated a noticeable HEV seroprevalence in HD patients (4)(5)(6). In contrast, some other reports demonstrated a low level of infection in their study group of HD patients.…”

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confidence: 66%

Anti-Hepatitis E Antibody in Hemodialysis Patients

Altuğlu¹,

Yaşar²,

Zeytinoğlu³

et al. 2018

Turk Neph Dial Transpl

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Hepatitis E Virus (HEV) is a significant health problem that causes hepatitis in developing countries and especially in Asia, Africa and Latin America (1). Even though the common route of transmission of HEV is fecal-oral, other probable modes of transmission in endemic areas include vertical transmission, blood transfusions, person-to-person contact and zoonotic transmission (2).To date, different studies have reported controversial results about the seroprevalence of HEV in hemodialysis (HD) patients and in most of the studies increased prevalence of HEV is noted (3). Herein, we report our experience of anti-HEV IgG seroprevalence in a selected population of HD patients in our hospital hemodialysis unit. The study was performed between the dates of August 2016 and November 2016 in serum samples of 68 patients (male n=40, female n=28) on maintenance HD, sent to our Serology laboratory for hepatitis screening. The mean age of the HD subjects was 49.2 ± Standard Deviation [SD] 16.8 years (age range: 19-83). Tests for the HEV serum marker (anti-HEV IgG) were carried out using a commercially available enzyme-linked immunosorbent assay kit (Euroimmun Anti-Hepatitis E Virus (HEV) ELISA (IgG), Germany). The tests were conducted in accordance with the manufacturer's instructions. Medical records were reviewed, and information on age, sex, HD duration, and evidence of hepatitis B or hepatitis C infection was collected. The mean duration of HD treatment was 37.9 (ranging between one month and 240 months). Three (4.5%) of the patients were infected with Hepatitis B (HBV) and 11 (16.4%) with hepatitis C virus (HCV). Among the evaluated individuals, the ELISA results demonstrated the existence of anti-HEV IgG antibody in only one patient (1.5%). In two patients, indeterminate ELISA results were obtained repeatedly in two different runs.Reports from Japan, Saudi Arabia and Greece have demonstrated a noticeable HEV seroprevalence in HD patients (4-6). In contrast, some other reports demonstrated a low level of infection in their study group of HD patients. For instance, in a study from Brazil, all chronically hemodialyzed patients were found to be seronegative for HEV (7). Most of the reports from Turkey of HEV seroprevalence are also in line with other studies and show a higher prevalence of anti-HEV in HD patients compared to healthy blood donors, ranging from 10.4% to 23.5% (8-10). In contrast to these reports, in few studies, no statistically significant difference was observed between the HEV prevalence in HD patients compared to the prevalence in the normal population (11, 12). In our study, seroprevalence of anti-HEV IgG is 1.5% (4.3 %with the grayzone results), which is lower than the prevalence in our region 6.6% (13). The association between anti-HEV positivity and the positivity for hepatitis B (HBV) or C virus (HCV) infection markers seems to be unclear (14). Some reports have shown a positive serostatus of HBV and HCV in anti-HEV-positive HD patients and an association between HBV or HCV acquisition HEV transmiss...

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Hepatitis E Virus Antibodies in Hemodialysis Patients: An Epidemiological Survey in Central Greece

Cited by 47 publications

References 24 publications

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

Anti-Hepatitis E Antibody in Hemodialysis Patients

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