Hepatitis Delta Virus: A Peculiar Virus

Alves, Carolina; Branco, Cristina de; Cunha, Celso

doi:10.1155/2013/560105

Cited by 29 publications

(21 citation statements)

References 110 publications

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“…Interestingly, thus far, only one naturally occurring circRNA is known to encode a single protein in eukaryotic cells, i.e., HDV, which is a subviral satellite virus of the hepatitis B virus (HBV) [5]. The encapsulation of HDV with HBV virions results in the production of a single viral protein that is specific to pathogenicity, but the principle of translation is noncanonical and probably associated with specific viral agents [55,56]. However, to date, there is no evidence that suggests that naturally occurring endogenous circRNAs undergo translation [10,12].…”

Section: Circrnas Regulate the Expression Of Parental Genementioning

confidence: 99%

Circular RNA: A new star of noncoding RNAs

et al. 2015

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Section: Circrnas Regulate the Expression Of Parental Genementioning

confidence: 99%

Circular RNA: A new star of noncoding RNAs

et al. 2015

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“…The hepatitis delta virus (HDV) also has a circular ssRNA genome. It encodes a single protein, and is a subviral satellite of hepatitis B virus (HBV) that gets encapsulated within HBV virions and thereby coinfects with HBV (Flores et al 2011;Abbas and Afzal 2013;Alves et al 2013).…”

Section: Different Types Of Rna Circles Circular Rna Genomes-viroid Amentioning

confidence: 99%

Circular RNAs: diversity of form and function

Lasda

Parker

2014

RNA

1,015

818

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It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5 ′ and 3 ′ ends of linear RNAs, as intermediates in RNA processing reactions, or by "backsplicing," wherein a downstream 5 ′ splice site (splice donor) is joined to an upstream 3 ′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions.

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“…1,2 It is a small, satellite, singlestranded RNA virus that requires the surface antigen of the hepatitis B virus (HBV) for assembly and transmission 3,4 and is associated with faster progression to cirrhosis, hepatic decompensation, hepatocellular carcinoma and death than HBV mono-infection. [5][6][7] Transmission of HDV in endemic areas is purportedly through horizontal intra-familial spread, although sexual transmission, 6 injecting drug use (IDU) and unsafe medical and dental practices are also risk factors. 8,9 Prevalence is not evenly distributed, with a higher burden of infection occurring in Mediterranean Europe, the Amazon Basin, Sub-Saharan Africa and parts of Asia.…”

Section: Introductionmentioning

confidence: 99%