Hepatitis C virus: prevalence and routes of infection among blood donors of West Mexico

Vivas-Arceo, Cecilia; Benavides, Sergio Aguilar; Trujillo, Janet; Panduro, Arturo; Rivas-Estilla, Ana María

doi:10.1016/s1386-6346(02)00243-7

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…Several epidemiological studies of HCV performed in Mexican people that included blood donors, [28-30] open population, [31,32] and patients with cirrhosis [33] mentioned dental treatment as a probable risk factor. Other studies found that living with a family member infected with HCV [34,35] or suffering from liver disease [33,36,37] was an associated risk factor. Although it is known that multiple factors contribute to HCV transmissibility for saliva [5,38] and viral loads are very low in this [39].…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

et al. 2014

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BackgroundHepatitis C virus (HCV) is mainly transmitted by parenteral route, being blood transfusion and intravenous drug use the most frequent risk factors. However, it has been suggested that there are other routes of transmission. There are several studies where HCV RNA has been detected in saliva of patients infected with HCV, and epidemiological studies have proposed the dental treatments as possible risk factors for HCV transmission. The purpose of this study was to detect the presence of HCV RNA in saliva of patients with active infection and associating with periodontal or liver disease.MethodsPatients with quantifiable HCV-RNA in serum were enrolled in the study. Periodontal disease was assessed using the modified gingival index (MGI). Presence of dental plaque was assessed with the use of disclosing tablets. Patients were clinically and laboratory evaluated to identify the stage of liver disease, the HCV RNA was determinate in saliva by nested RT-PCR. To determine associations between different parameters univariate and multivariate analysis were used.ResultsA total of 45 patients were included. Of these patients, 21 (46.6%) had hepatitis, 23 (51.1%) had cirrhosis and one patient (2.4%) presented hepatocellular carcinoma (HCC). Viral loads in serum ranged from 2.31–6.68 log IU/ml with a mean of 5.46 log IU/ml (95% CI 5.23–5.70). HCV RNA was positive in saliva of 29 patients (64.4%) and was not detected in 16 (35.6%). For univariate analysis three independent variables were associated with the detection of HCV-RNA in saliva: gender, viral load and dental plaque and multivariate analysis only one independent variable viral load >5.17 log IU/mL remained significantly associated with the detection of HCV in saliva (p = 0.0002). A statistical difference was observed when viral load was analyzed, log 5.85 IU/mL (95% CI 5.67–6.02) for patients with HCV in saliva vs. log 4.77 IU/mL (95% CI 4.35–5.19) for patients without HCV in saliva (p = 0.0001). The detection of HCV-RNA in saliva was more frequent in patients with relatively high serum viral loads.ConclusionHCV-RNA in saliva was associated with the level of serum viral load but not with periodontal or liver disease severity.

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Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

et al. 2014

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“…It has been difficult to estimate precisely how many asymptomatic HCV-infected persons are at significant risk for progressive liver disease (17), because most of the epidemiological studies in Mexico on HCV infection have been conducted on blood donors, which has resulted in limited available information on the actual burden of HCV in the general population. In a previous study on blood donors (18), we found a 0.47% prevalence of HCV infection, which is the lowest prevalence reported in Mexico: intermediate prevalences were reported as 0.7-0.8% (19,20), with the highest prevalence being 1.47% (21). In the present study, we found a prevalence of 2%, which is higher than that found in blood donors and similar to that reported in another asymptomatic population assessed by PCR (1.76%) (7).…”

Section: Discussionmentioning

confidence: 68%

Prevalence of Hepatitis C Infection in a Population of Asymptomatic People in a Checkup Unit in Mexico City

et al. 2005

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Hepatitis C virus (HCV) infection has an estimated prevalence of 3% around the world. Unfortunately, many persons with HCV infection are asymptomatic. The aim of this study was to determine the prevalence of hepatitis C Virus infection in asymptomatic persons. This study was carried out in a population-based cross-sectional study in the Checkup Unit of University Hospital in Mexico City. Patients with two or more HCV risk factors were studied. Serum specimens from all patients were screened for HCV RNA by qualitative polymerase chain reaction (PCR). HCV RNA-positive serum was also screened by quantitative PCR and for HCV genotype. Three hundred asymptomatic people were included, 194 men and 106 women, with a mean age of 46.8+/-11.9. Six (2%) of the 300 people were positive and viremic. The most common risk factors in positive patients were manicures or pedicures with a nonpersonal instrument and more than three sexual partners. We concluded that hepatitis C is frequent in asymptomatic people, and those people are often viremic. In addition, this study suggests that the spectrum of liver disease in asymptomatic and newly diagnosed HCV-positive persons is broad.

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“…In countries in which the use of illicit intravenous drugs is not frequent, the recipients of transfusion before the systematic screening for the hepatitis C virus (HCV) in blood banks represent the largest group of persons with the infection [1][2][3][4][5]. Several risk factors for HCV infection and for the progression of the liver disease may differ by gender [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Several risk factors for HCV infection and for the progression of the liver disease may differ by gender [6][7][8][9][10]. Compared with men, in some countries women have transfusion of blood products as the main route of acquisition of HCV [1,9]. Nevertheless, little is known about the indication for blood transfusion in women who underwent this procedure before the screening programs [10] and the relation of this antecedent with the progression of the liver disease.…”

Section: Introductionmentioning

confidence: 99%

Routes of infection and clinical outcome of Mexican women reactive to anti-hepatitis C virus antibodies

Chiquete

Sánchez

Panduro

2006

Hepatology Research

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Hepatitis C virus: prevalence and routes of infection among blood donors of West Mexico

Cited by 21 publications

References 42 publications

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

Prevalence of Hepatitis C Infection in a Population of Asymptomatic People in a Checkup Unit in Mexico City

Routes of infection and clinical outcome of Mexican women reactive to anti-hepatitis C virus antibodies

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