Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-1beta in HEK293T Cells with Reconstructed NLRP3 Inflammasome
А. A. Latanova,
K. K. Tuchinskaya,
E. S. Starodubova
et al.
Abstract:Infections caused by Flaviviridae pose a threat in the modern world. The pathology of diseases arising from these infections is largely determined by the development of systemic inflammation. The cytokines interleukin-1 beta and interleukin-18 play a key role in triggering inflammation. Their secretion from cells, in its turn, is induced upon activation of inflammasomes. Activation of NLRP3 (NLR family pyrin domain-containing 3) inflammasomes was detected in the cells infected with Flaviviridae. Some nonstruct… Show more
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