Hepatitis C Virus Is Not Associated With an Increased Risk of Colorectal Polyps in Cirrhotic Patients Undergoing Screening Colonoscopy

Bhatt, Birju D.; Lukose, Thresiamma; Brown, Robert E.; Verna, Elizabeth C.

doi:10.14309/00000434-201410002-00432

Cited by 4 publications

(5 citation statements)

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“…Similar results were also reported in two retrospective cohort studies from the USA and China. [34,35]. Interestingly, a study examining the relationship between the liver-to-spleen ratio on computed tomography and colorectal polyps found that an increased amount of liver fat was drastically linked to a heightened susceptibility to colorectal polyps, which is similar to our results adopting MRI-based percent liver fat as a feature of NAFLD [36].…”

Section: Discussionsupporting

confidence: 87%

Non-alcoholic fatty liver disease and colorectal adenoma/polyps: A Two-Sample Mendelian randomization study.

Kong,

Tan,

2023

Preprint

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Background: A potential link between non-alcoholic fatty liver disease (NAFLD) and colorectal adenoma/polyps has been suggested by observational studies, which have inherent limitations that make them unsuitable for assessing causality. We designed a two-sample Mendelian randomization (MR) study to assess the causal effects of NAFLD on adenoma/polyps in the colorectum and its eight segments. Methods: Genetic instruments were utilized as proxies for NAFLD and colorectal adenoma/polyps, and those for NAFLD were described by NAFLD clinical diagnosis and percent liver fat. Genome-wide association study (GWAS) data were obtained from GWAS Catalog and FinnGen consortium. Results: In inverse-variance weighted (IVW) models, both NAFLD clinical diagnosis [odds ratio (OR) = 1.05, 95% confidence interval (CI): 1.02-1.09, false discovery rate (FDR) = 0.008] and percent liver fat (OR = 1.08, 95% CI: 1.04-1.13, FDR = 0.001) were significantly associated with colorectal adenoma/polyps, which proved to be plausible in sensitivity analysis. As for individual segments of the colorectum, the results revealed that both NAFLD clinical diagnosis (OR = 1.10, 95% CI: 1.04-1.17, FDR = 0.010) and percent liver fat (OR = 1.17, 95% CI: 1.04-1.32, FDR = 0.034) were significantly associated with rectal adenoma/polyps without heterogeneity or pleiotropy. However, NAFLD did not show significant associations with adenoma/polyps in other segments of the colorectum. Conclusion: Our finding supported a causal effect of NAFLD on colorectal adenoma/polyps, particularly those in the rectum.

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Section: Discussionsupporting

confidence: 87%

Non-alcoholic fatty liver disease and colorectal adenoma/polyps: A Two-Sample Mendelian randomization study.

Kong,

Tan,

2023

Preprint

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Section: Discussionmentioning

confidence: 99%

“…A large number of studies have confirmed a close correlation between colorectal adenoma and MAFLD [ 37 , 38 ]. Bhatt et al, in a retrospective analysis of liver transplant patients, reported that patients with MAFLD had a 2-fold increased risk of colorectal adenoma relative to patients with other end-stage liver diseases [ 37 ]. A meta-analysis of 6263 subjects revealed a significant association between MAFLD and colorectal adenomas, and this association was more pronounced in Asian populations [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma

Xiong,

Wu,

Chen

et al. 2024

BMC Gastroenterol

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Objective To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma. Methods A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared. Results High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma. Conclusion MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma.

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“…The significant association between NAFLD and colorectal polyps has been recognized by several researchers. Bhatt et al [13] conducted a retrospective cohort study, and demonstrated that NAFLD was a significant predictor of finding colorectal polyps on colonoscopy (adjusted OR = 2.42; 95% CI: 1.42-4.11; P = 0.001), as well as adenomatous polyps (adjusted OR = 1.95; 95% CI: 1.09-3.48; P = 0.02). However, the relation between NAFLD and non-adenomatous polyps was not examined.…”

Section: Discussionmentioning

confidence: 99%

Association of nonalcoholic fatty liver disease with colorectal adenomatous polyps and non-adenomatous polyps: a cross-sectional study

Yang,

Teng,

Shi

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Aim This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non- adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD. Methods A retrospective, cross-sectional study was conducted at the First People’s Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who underwent abdominal ultrasonography and colonoscopy over a 5 year period. We compared characteristics among patients with adenomatous polyps, non-adenomatous polyps, and without colorectal polyps using descriptive statistics. Logistic regression analyses were used to detect associations between NAFLD with the prevalence of adenomatous polyps and non-adenomatous polyps. NAFLD was determined by abdominal ultrasound. Colorectal polyps were assessed by data in the colonoscopy report and pathology report. Results A total of 65% of patients with NAFLD had colorectal polys (52% adenomatous polyps and 13% non-adenomatous polyps), and 40% of patients without NAFLD had polyps (29% adenomatous polyps and 11% non-adenomatous polyps). After adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous in males and females [odds ratio (OR) = 1.8, 95% confidence interval (CI): 1.6–2.2, P < 0.01], but was not associated with non-adenomatous polyps (OR = 1.2, 95% CI:0.9–1.5, P > 0.05). Conclusion NAFLD is associated with an increased risk of colorectal adenomatous polyps compared to the absence of polyps, but not associated with an increased risk of non-adenomatous polyps. These results provide important evidence for the prevention of CRC in patients with NAFLD.

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Hepatitis C Virus Is Not Associated With an Increased Risk of Colorectal Polyps in Cirrhotic Patients Undergoing Screening Colonoscopy

Cited by 4 publications

References 0 publications

Non-alcoholic fatty liver disease and colorectal adenoma/polyps: A Two-Sample Mendelian randomization study.

Non-alcoholic fatty liver disease and colorectal adenoma/polyps: A Two-Sample Mendelian randomization study.

MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma

Association of nonalcoholic fatty liver disease with colorectal adenomatous polyps and non-adenomatous polyps: a cross-sectional study

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