Hepatitis C virus infections and associated risk factors in patients with diabetes mellitus; case control study in North West Tigray, Ethiopia

Gebrekristos, Gebretsakan; Teweldemedhin, Mebrahtu; Hagos, Letebrhan; Gebrewahid, Tuom; Gidey, Berihu; Gebreyesus, Hailay

doi:10.1186/s13104-018-3983-4

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Current or previous sexual activity (P = 0.003) was associated with seropositivity which was consistent with a study by Okafor et al [ 24 ] and positive HIV status (P = 0.012) was also associated with seropositivity which was also consistent with work done by Gebrekristos et al in Ethiopia [ 39 ], where immunosuppression was associated with anti-HCV seropositivity. Other risk factor associations with seropositivity included previous maternal positive test for anti-HCV (P = 0.000) and history of FGM or circumcision (P = 0.032).…”

Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Siaw,

Amugsi,

Owusu-Konadu

et al. 2024

PLoS ONE

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Hepatitis C virus (HCV) infection remains a major cause of liver related morbidity and mortality worldwide. Epidemiologic data on seroprevalence, viremia prevalence and risk factors remain limited in sub-Saharan Africa. In Ghana, HCV-related deaths are estimated to have increased since 2015. Risk factors associated with HCV infection in Ghana are not well described. The aim of this study was to determine the prevalence of, and risk factors associated with hepatitis C virus infection in the Upper East Region located in the northern part of Ghana. A community-based cross-sectional study was conducted in 9 communities in the Upper East region of Ghana. A total of 1,769 participants aged ≥12 years were screened for HCV antibody (anti-HCV) using rapid diagnostic testing (RDT). Seventy-four participants undertook HCV RNA testing after a positive anti-HCV result. Multivariate logistic regression was used to determine risk factors associated with HCV seropositivity. The anti-HCV prevalence was 8.4%, with 149 out of 1,769 testing anti-HCV positive. Mean age (±SD) of seropositive persons was 45.4 (±16.3) years. The highest anti-HCV seroprevalence was amongst persons aged 60 years and above. Forty-four out of 74 (59.5%) seropositive cases had viremic infection and the estimated viremic prevalence in the screened population was 5.0%. Predictors of HCV seropositivity were age (OR 1.03 95% CI 1.01–1.04), history of female genital mutilation or circumcision (OR 1.63 95% CI 1.04–2.55), sexual activity (OR 2.57 95% CI 1.38–4.79), positive maternal HCV status (OR 10.38 95% CI 4.13–26.05) and positive HIV status (OR 4.03 95% CI 1.35–12.05). In conclusion, the Upper East Region demonstrates a high Hepatitis C antibody prevalence. Almost 60% of individuals have viremic infection, however the cost of RNA testing is a barrier to virological diagnosis. There is a need to educate the population about HCV-associated risk factors to reduce HCV transmission and burden of disease.

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Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Siaw,

Amugsi,

Owusu-Konadu

et al. 2024

PLoS ONE

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“…This result could be justified not only by the high representation of women in society but also by their greater attendance at healthcare facilities. The majority of participants had a primary level of education (38%), this is in line with the study by Gebrekristos et al, in Ethiopia, which reports a proportion of 36.5% of participants with a primary level of education [16]. This justifies the fact that most respondents had heard of hepatitis B and C, but did not know the mode of transmission.…”

Section: Discussionsupporting

confidence: 88%

Frequency of B and C Hepatitis Viruses, and Metabolic Profile in Type 2 Diabetics: A Case of the Yaoundé Central Hospital, Cameroon

Sikati¹,

Mbah²,

Nyunaï³

et al. 2023

OJEpi

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Poorly controlled type 2 diabetes alters the immune system, increasing the risk of susceptibility to viral infections such as hepatitis B and C infections. This study aimed to determine the frequency of hepatitis B and C and metabolic profiles in type 2 diabetics. This was a cross-sectional study conducted over six months. It was conducted at the National Obesity Center (NOC) of the Yaoundé Central Hospital (YCH), Cameroon. 100 diabetic patients, with a mean age of 58.41 ± 10.74 years were enrolled in the study. The socio-demographic characteristics of the study population and the risk factors for virus transmission were recorded using a pre-established questionnaire. HBsAg and anti-HCV antibodies were revealed by a rapid diagnostic test. Liver function markers' activities were determined. Commercial kits were used to evaluate the patient's serum lipid profile, serum fasting glucose level, urea, creatinine, and albumin. With a sex ratio of 3:1, women outnumbered men. Risk factors for HCV and HBV infections evocated by the population were dental care (50%), followed by alcohol consumption (41%). HBsAg and anti-HCV antibodies frequency was 3% and 8% respectively. No cases of coinfection were found. In general, hypertriglyceridemia with a mean of 1.61 ± 0.46 g/L and hyperglycemia of 1.35 ± 0.45 g/L were noted. A significant difference (p = 0.028) was found in HDL-cholesterol values between non-co-affected diabetics and HCV+ diabetics. The effect of the duration of diabetes on biochemical parameters revealed that albumin was the only significant decrease over time (p = 0.013). Based on these results, the metabolic profile of patients was altered. It is important to take note of the prevalence of hepatitis seen in type 2 diabetes mellitus since it demonstrates the potential link between both illnesses. Thus, early detection could prevent complications related to B and C

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“…There are number of studies suggesting the possible positive association between the chronic HCV infection and DM. 17 The study conducted by Gebrekristos et al, 15 manifested that out of 77 (16.7%) seroprevalence HCV, major proportion HCV was found among patients with DM being 64 (28%) versus 13 (6%) in other patients without DM. In another study, 200 patients recruited from UK for a prospective study revealed the higher incidence of chronic HCV infection among patients with DM.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, it is not surprising that 70% patients with cirrhosis have impaired glucose tolerance and relatively fewer patients develop overt DM. 15 Insulin resistance, hyperinsulinemia and hyperglucagonemia form the underlying basis of this abnormal glucose metabolism. The patients with advanced CLD are at risk to develop hyperglycemia even with usual doses of steroids or interferon.…”

Section: Discussionmentioning

confidence: 99%

Association of Type 2 Diabetes Mellitus with Chronic Hepatitis C Virus Infection

Rafique

Amir

Khaskheli

et al. 2022

PAFMJ

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Objective: To determine the association of type 2 diabetes mellitus with chronic hepatitis C virus (HCV) infection. Study Design: Case control study. Place and Duration of Study: Combined Military Hospital, Peshawar Pakistan, from Jun 2017 to Jun 2018. Methodology: After fulfilling the inclusion criteria, 190 patients were enrolled in the study and divided into two equal groups. The patients of either gender with positive anti-hepatitis C antibodies/PCR for HCV, ribonucleic acid (RNA) were included as cases and apparently healthy individuals reporting for blood donation were included as controls. Plasma glucose was tested by hexokinase enzymatic method using Advia 1800 after 8 hours fast. Then the association between the two major diseases was observed. Results: Patients in the case and control groups had the mean age of 40.26 ± 8.05 and 40.29 ± 8.89 years respectively whereas body mass index in the case group was 26.60 ± 1.67 kg/m2 and 26.05 ± 1.49 kg/m2 in the control group. Mean duration of HCV infection was 7.03 ± 2.21 months in the case group. Mean serum ALT level was 46.81 ± 7.25 U/L in the case group and 28.43 ± 4.66 U/L in the control group. A total of 76.8% of patients in case group had been treated for HCV infection previously. Type 2 diabetes was seen in 38 (40%) cases and 19 (20%) controls (Odd Ratio=2.60; p=0.002). Conclusion: Type 2 diabetes mellitus is more frequent amongst HCV positive patients as compared to HCV negative patients.

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Hepatitis C virus infections and associated risk factors in patients with diabetes mellitus; case control study in North West Tigray, Ethiopia

Cited by 7 publications

References 24 publications

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Frequency of B and C Hepatitis Viruses, and Metabolic Profile in Type 2 Diabetics: A Case of the Yaoundé Central Hospital, Cameroon

Association of Type 2 Diabetes Mellitus with Chronic Hepatitis C Virus Infection

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Hepatitis C virus infections and associated risk factors in patients with diabetes mellitus; case control study in North West Tigray, Ethiopia

Cited by 7 publications

References 24 publications

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Prevalence and risk factors of Hepatitis C virus infection in the Upper East Region of Ghana; a community-based cross-sectional study

Frequency of B and C Hepatitis Viruses, and Metabolic Profile in Type 2 Diabetics: A Case of the Yaound&#233; Central Hospital, Cameroon

Association of Type 2 Diabetes Mellitus with Chronic Hepatitis C Virus Infection

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Frequency of B and C Hepatitis Viruses, and Metabolic Profile in Type 2 Diabetics: A Case of the Yaoundé Central Hospital, Cameroon